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Protein

DNA-(apurinic or apyrimidinic site) lyase

Gene

APEX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Probably binds two magnesium or manganese ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, EndonucleaseUniRule annotationImported, Hydrolase, LyaseUniRule annotationImported, Nuclease
Biological processDNA damage, DNA repairUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Gene namesi
Name:APEX2Imported
ORF Names:hCG_18950Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000169188.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, MitochondrionUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiE5KN95

Expressioni

Gene expression databases

BgeeiENSG00000169188
ExpressionAtlasiE5KN95 baseline and differential

Structurei

3D structure databases

SMRiE5KN95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 304Endo/exonuclease/phosphataseInterPro annotationAdd BLAST300
Domaini467 – 515zf-GRFInterPro annotationAdd BLAST49

Sequence similaritiesi

Belongs to the DNA repair enzymes AP/ExoA family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1294 Eukaryota
COG0708 LUCA
KOiK10772
OMAiGAFTCWS
OrthoDBiEOG091G0IPG

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR004808 AP_endonuc_1
IPR020847 AP_endonuclease_F1_BS
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR010666 Znf_GRF
PANTHERiPTHR22748 PTHR22748, 1 hit
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PF06839 zf-GRF, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
TIGRFAMsiTIGR00633 xth, 1 hit
PROSITEiView protein in PROSITE
PS00726 AP_NUCLEASE_F1_1, 1 hit
PS51435 AP_NUCLEASE_F1_4, 1 hit

Sequencei

Sequence statusi: Complete.

E5KN95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVVSWNIN GIRRPLQGVA NQEPSNCAAV AVGRILDELD ADIVCLQETK
60 70 80 90 100
VTRDALTEPL AIVEGYNSYF SFSRNRSGYS GVATFCKDNA TPVAAEEGLS
110 120 130 140 150
GLFATQNGDV GCYGNMDEFT QEELRALDSE GRALLTQHKI RTWEGKEKTL
160 170 180 190 200
TLINVYCPHA DPGRPERLVF KMRFYRLLQI RAEALLAAGS HVIILGDLNT
210 220 230 240 250
AHRPIDHWDA VNLECFEEDP GRKWMDSLLS NLGCQSASHV GPFIDSYRCF
260 270 280 290 300
QPKQEGAFTC WSAVTGARHL NYGSRLDYVL GDRTLVIDTF QASFLLPEVM
310 320 330 340 350
GSDHCPVGAV LSVSSVPAKQ CPPLCTRFLP EFAGTQLKIL RFLVPLEQSP
360 370 380 390 400
VLEQSTLQHN NQTRVQTCQN KAQVRSTRPQ PSQVGSSRGQ KNLKSYFQPS
410 420 430 440 450
PSCPQASPDI ELPSLPLMSA LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE
460 470 480 490 500
LRTSFWKSVL AGPLRTPLCG GHREPCVMRT VKKPGPNLGR RFYMCARPRG
510
PPTDPSSRCN FFLWSRPS
Length:518
Mass (Da):57,401
Last modified:February 8, 2011 - v1
Checksum:i08464806153F8832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205186 Genomic DNA Translation: ADP90654.1
HQ205187 Genomic DNA Translation: ADP90655.1
HQ205188 Genomic DNA Translation: ADP90656.1
HQ205189 Genomic DNA Translation: ADP90657.1
HQ205190 Genomic DNA Translation: ADP90658.1
HQ205191 Genomic DNA Translation: ADP90659.1
HQ205192 Genomic DNA Translation: ADP90660.1
HQ205193 Genomic DNA Translation: ADP90661.1
HQ205194 Genomic DNA Translation: ADP90662.1
HQ205195 Genomic DNA Translation: ADP90663.1
HQ205196 Genomic DNA Translation: ADP90664.1
HQ205197 Genomic DNA Translation: ADP90665.1
HQ205198 Genomic DNA Translation: ADP90666.1
HQ205199 Genomic DNA Translation: ADP90667.1
HQ205200 Genomic DNA Translation: ADP90668.1
HQ205201 Genomic DNA Translation: ADP90669.1
HQ205202 Genomic DNA Translation: ADP90670.1
HQ205204 Genomic DNA Translation: ADP90672.1
HQ205205 Genomic DNA Translation: ADP90673.1
HQ205206 Genomic DNA Translation: ADP90674.1
HQ205207 Genomic DNA Translation: ADP90675.1
HQ205208 Genomic DNA Translation: ADP90676.1
HQ205209 Genomic DNA Translation: ADP90677.1
HQ205210 Genomic DNA Translation: ADP90678.1
HQ205211 Genomic DNA Translation: ADP90679.1
HQ205212 Genomic DNA Translation: ADP90680.1
HQ205213 Genomic DNA Translation: ADP90681.1
HQ205214 Genomic DNA Translation: ADP90682.1
HQ205215 Genomic DNA Translation: ADP90683.1
HQ205216 Genomic DNA Translation: ADP90684.1
HQ205217 Genomic DNA Translation: ADP90685.1
HQ205218 Genomic DNA Translation: ADP90686.1
HQ205219 Genomic DNA Translation: ADP90687.1
HQ205221 Genomic DNA Translation: ADP90689.1
HQ205222 Genomic DNA Translation: ADP90690.1
HQ205223 Genomic DNA Translation: ADP90691.1
HQ205224 Genomic DNA Translation: ADP90692.1
HQ205225 Genomic DNA Translation: ADP90693.1
CH471154 Genomic DNA Translation: EAW93209.1
RefSeqiNP_055296.2, NM_014481.3
UniGeneiHs.659558

Genome annotation databases

GeneIDi27301
KEGGihsa:27301

Similar proteinsi

Entry informationi

Entry nameiE5KN95_HUMAN
AccessioniPrimary (citable) accession number: E5KN95
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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