Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 93 (11 Dec 2019)
Sequence version 1 (08 Feb 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Beta-lactamase

Gene

blaNDM-1

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi120Zinc; via tele nitrogenCombined sources1
Metal bindingi122Zinc; via pros nitrogenCombined sources1
Metal bindingi189Zinc; via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001721525:MS6198_RS26195-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Beta-lactamaseImported
Submitted name:
Beta-lactamase NDM-1Imported
Submitted name:
BlaNDM-1Imported
Submitted name:
BlaNDM-1 metallo beta lactamaseImported
Submitted name:
Class B beta-lactamase NDM-1Imported
Submitted name:
Metallo-beta-lactamaseImported
Submitted name:
Metallo-beta-lactamase NDM-1Imported
Submitted name:
NDM-1 metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamase NDM-1Imported
Submitted name:
Subclass B1 metallo-beta-lactamase NDM-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:blaNDM-1Imported
Synonyms:bla NDM-1Imported
ORF Names:APU18_05360Imported, AZ95_0035Imported, BANRA_05542Imported, BVL39_26630Imported, C6985_28190Imported, D3O91_26550Imported, DWB25_28700Imported, ECS01_0033Imported, EJC75_01690Imported, MS6198_A142Imported, NDM1Dok01_N0175Imported, pNDM102337_147Imported, pNDM10505_149Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid p1540-2Imported
Plasmid p271AImported
Plasmid pABC85Imported
Plasmid pACT1-EC-NDM-1Imported
Plasmid pACT2-NDM-1Imported
Plasmid pBJ01Imported
Plasmid pCR7-EC-NDM-1Imported
Plasmid pCRE10.4Imported
Plasmid pEc2AImported
Plasmid pGD31-NDMImported
Plasmid pGUE-NDMImported
Plasmid pHNEC55Imported
Plasmid pHNTS79-NDMImported
Plasmid pIMD989Imported
Plasmid pLK75Imported
Plasmid pMC-NDMImported
Plasmid pMS6198AImported
Plasmid pNDM-1_Dok01Imported
Plasmid pNDM-ECS01Imported
Plasmid pNDM-EcoGN568Imported
Plasmid pNDM-HKImported
Plasmid pNDM-HU01Imported
Plasmid pNDM102337Imported
Plasmid pNDM10505Imported
Plasmid pPN66-ECL-NDM-1Imported
Plasmid pcre10.4Imported
Plasmid pgd31-ndmImported
Plasmid pms6198aImported
Plasmid unnamedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000240026 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000281521 Componenti: Unassembled WGS sequence
  • UP000283743 Componenti: Unassembled WGS sequence
  • UP000094504 Componenti: Plasmid pms6198a
  • UP000292540 Componenti: Plasmid pcre10.4
  • UP000234906 Componenti: Plasmid p1540-2
  • UP000282525 Componenti: Plasmid pgd31-ndm
  • UP000053450 Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 250Lactamase_BInterPro annotationAdd BLAST177

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00753 Lactamase_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00849 Lactamase_B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56281 SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KIY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV
60 70 80 90 100
FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ
110 120 130 140 150
ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP
160 170 180 190 200
QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG
210 220 230 240 250
TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH
260 270
SAPDSRAAIT HTARMADKLR
Length:270
Mass (Da):28,499
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B6009120B945F14
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ162469 Genomic DNA Translation: ADP20459.1
HQ451074 Genomic DNA Translation: ADY00041.1
JF922606 Genomic DNA Translation: AEH43774.1
JF785549 Genomic DNA Translation: AEK64842.1
JF503991 Genomic DNA Translation: AEN71485.1
JF714412 Genomic DNA Translation: AEP32605.1
JQ364967 Genomic DNA Translation: AFI72857.1
JX000475 Genomic DNA Translation: AFN73221.1
JX296013 Genomic DNA Translation: AFU75168.1
KC149527 Genomic DNA Translation: AGB57374.1
KF951455 Genomic DNA Translation: AHK80864.1
KF951456 Genomic DNA Translation: AHK80865.1
KJ413946 Genomic DNA Translation: AHX39447.1
KJ558506 Genomic DNA Translation: AIA22330.1
KJ802404 Genomic DNA Translation: AIM48196.1
KJ440076 Genomic DNA Translation: AIU96948.1
KM111580 Genomic DNA Translation: AIZ65660.1
KM111584 Genomic DNA Translation: AIZ65664.1
KM111585 Genomic DNA Translation: AIZ65665.1
KM485656 Genomic DNA Translation: AIZ65943.1
KP027046 Genomic DNA Translation: AJL35292.1
KP826702 Genomic DNA Translation: AKN35214.1
KP826703 Genomic DNA Translation: AKN35231.1
KP826713 Genomic DNA Translation: AKN35341.1
KP772144 Genomic DNA Translation: AKT45764.1
KP772147 Genomic DNA Translation: AKT45767.1
KP772166 Genomic DNA Translation: AKT45786.1
KP772192 Genomic DNA Translation: AKT45812.1
KP770028 Genomic DNA Translation: ALD19858.1
KR822247 Genomic DNA Translation: ALF35449.1
KT879914 Genomic DNA Translation: ALP68872.1
CP015835 Genomic DNA Translation: AOM73211.1
MF383355 Genomic DNA Translation: ATB17817.1
CP019053 Genomic DNA Translation: AUL71622.1
CP031297 Genomic DNA Translation: AZR92250.1
AB604953 Genomic DNA Translation: BAK40112.1
AP012208 Genomic DNA Translation: BAK69668.1
AB769140 Genomic DNA Translation: BAN37431.1
HG003695 Other DNA Translation: CDF66128.1
LN871243 Genomic DNA Translation: CTQ31245.1
LNIP01000003 Genomic DNA Translation: KSZ23519.1
PVOU01000060 Genomic DNA Translation: PSF19244.1
CP034403 Genomic DNA Translation: QAZ84747.1
QXNW01000076 Genomic DNA Translation: RHX50739.1
UWXJ01000003 Genomic DNA Translation: VCZ28695.1

NCBI Reference Sequences

More...
RefSeqi
WP_004201164.1, NZ_VOMM01000165.1
YP_004765050.1, NC_015872.1
YP_006903357.1, NC_019045.2
YP_006939981.1, NC_018994.1
YP_006952434.1, NC_019063.1
YP_006953215.1, NC_019069.1
YP_006953875.1, NC_019089.1
YP_009059936.1, NC_024954.1
YP_009066439.1, NC_025106.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ANM85706; ANM85706; A8V37_24690
AOM73211; AOM73211; MS6198_A142
KSZ23519; KSZ23519; APU18_05360

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11027496
13876866
13903469
13905367
13906127
13906812
20466712
20471936
39872256

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.12826.peg.5242

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ162469 Genomic DNA Translation: ADP20459.1
HQ451074 Genomic DNA Translation: ADY00041.1
JF922606 Genomic DNA Translation: AEH43774.1
JF785549 Genomic DNA Translation: AEK64842.1
JF503991 Genomic DNA Translation: AEN71485.1
JF714412 Genomic DNA Translation: AEP32605.1
JQ364967 Genomic DNA Translation: AFI72857.1
JX000475 Genomic DNA Translation: AFN73221.1
JX296013 Genomic DNA Translation: AFU75168.1
KC149527 Genomic DNA Translation: AGB57374.1
KF951455 Genomic DNA Translation: AHK80864.1
KF951456 Genomic DNA Translation: AHK80865.1
KJ413946 Genomic DNA Translation: AHX39447.1
KJ558506 Genomic DNA Translation: AIA22330.1
KJ802404 Genomic DNA Translation: AIM48196.1
KJ440076 Genomic DNA Translation: AIU96948.1
KM111580 Genomic DNA Translation: AIZ65660.1
KM111584 Genomic DNA Translation: AIZ65664.1
KM111585 Genomic DNA Translation: AIZ65665.1
KM485656 Genomic DNA Translation: AIZ65943.1
KP027046 Genomic DNA Translation: AJL35292.1
KP826702 Genomic DNA Translation: AKN35214.1
KP826703 Genomic DNA Translation: AKN35231.1
KP826713 Genomic DNA Translation: AKN35341.1
KP772144 Genomic DNA Translation: AKT45764.1
KP772147 Genomic DNA Translation: AKT45767.1
KP772166 Genomic DNA Translation: AKT45786.1
KP772192 Genomic DNA Translation: AKT45812.1
KP770028 Genomic DNA Translation: ALD19858.1
KR822247 Genomic DNA Translation: ALF35449.1
KT879914 Genomic DNA Translation: ALP68872.1
CP015835 Genomic DNA Translation: AOM73211.1
MF383355 Genomic DNA Translation: ATB17817.1
CP019053 Genomic DNA Translation: AUL71622.1
CP031297 Genomic DNA Translation: AZR92250.1
AB604953 Genomic DNA Translation: BAK40112.1
AP012208 Genomic DNA Translation: BAK69668.1
AB769140 Genomic DNA Translation: BAN37431.1
HG003695 Other DNA Translation: CDF66128.1
LN871243 Genomic DNA Translation: CTQ31245.1
LNIP01000003 Genomic DNA Translation: KSZ23519.1
PVOU01000060 Genomic DNA Translation: PSF19244.1
CP034403 Genomic DNA Translation: QAZ84747.1
QXNW01000076 Genomic DNA Translation: RHX50739.1
UWXJ01000003 Genomic DNA Translation: VCZ28695.1
RefSeqiWP_004201164.1, NZ_VOMM01000165.1
YP_004765050.1, NC_015872.1
YP_006903357.1, NC_019045.2
YP_006939981.1, NC_018994.1
YP_006952434.1, NC_019063.1
YP_006953215.1, NC_019069.1
YP_006953875.1, NC_019089.1
YP_009059936.1, NC_024954.1
YP_009066439.1, NC_025106.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
5YPIX-ray2.30A/B/C/D/E/F/G/H29-270[»]
5YPKX-ray2.00A/B/C/D/E/F/G/H29-270[»]
5YPLX-ray1.80A/B29-270[»]
5YPMX-ray2.15A/B/C/D/E/F/G/H29-270[»]
5YPNX-ray2.12A/B29-270[»]
5ZR8X-ray1.50A/E29-270[»]
6C89X-ray1.75A/B/C/D40-270[»]
6OVZX-ray2.02A/B36-270[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiANM85706; ANM85706; A8V37_24690
AOM73211; AOM73211; MS6198_A142
KSZ23519; KSZ23519; APU18_05360
GeneIDi11027496
13876866
13903469
13905367
13906127
13906812
20466712
20471936
39872256
PATRICifig|562.12826.peg.5242

Enzyme and pathway databases

BioCyciGCF_001721525:MS6198_RS26195-MONOMER

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KIY2_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KIY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: December 11, 2019
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again