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Entry version 43 (16 Jan 2019)
Sequence version 1 (08 Feb 2011)
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Protein

Protein TOPAZ1

Gene

Topaz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TOPAZ1Curated
Alternative name(s):
Testis- and ovary-specific PAZ domain-containing protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Topaz11 PublicationImported
Synonyms:Gm9524Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:3779933 Topaz1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Males are infertile, while female fertility is not affected. Testis size is significantly reduced with the phenotype apparent from postnatal day 28 (P28) onwards. Testicular histology appears to be normal before P28, but then cell aggregates begin to accumulate in the center of seminiferous tubules. Sperm development arrests at the post-meiotic round spermatid stage, associated with increased apoptosis. Adult testes completely lack round spermatids and spermatozoa. Meiosis appears to be normal up to the pachytene stage, with no apparent effect on synaptonemal complex formation or meiotic sex chromosome inactivation. However, chromosome alignment on the metaphase plate may be abnormal. In stage P20 testes, 99 gene transcripts show abnormal expression levels, including around 10 lincRNAs.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004160611 – 1653Protein TOPAZ1Add BLAST1653

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
E5FYH1

PRoteomics IDEntifications database

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PRIDEi
E5FYH1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E5FYH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E5FYH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to testis, where it localizes to germ cells.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In both developing female and male gonads, first detected at 12.5 dpc, expression increases until 16.5 dpc and then drops (PubMed:22069478). Divergence between male and female expression starts around 5 days after birth (PubMed:22069478). In ovaries, expression decreases and becomes hardly detectable in adult ovaries, while in testis, expression increases 5 days after birth and becomes strong in the adult (PubMed:22069478). In both males and females, expression is restricted to germ cells (PubMed:22069478). In developing male germ cells, highly expressed at the spermatocyte stage; has little or no expression in round spermatids, elongated spermatids or spermatozoa (PubMed:26358182).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000094985 Expressed in 4 organ(s), highest expression level in testis

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGNR Eukaryota
ENOG4111I5N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012495

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E5FYH1

Identification of Orthologs from Complete Genome Data

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OMAi
YYRKFPP

Database of Orthologous Groups

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OrthoDBi
347766at2759

TreeFam database of animal gene trees

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TreeFami
TF338635

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038952 TOPAZ1
IPR029435 TOPAZ1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR35671 PTHR35671, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14669 Asp_Glu_race_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5FYH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPPATPPDP TKEPGCKGTT RGLRKRGLPL TPEPGEGGGC SLEARGCEEE
60 70 80 90 100
SRQKQRMVTQ ASGREETEGD KLAKENGKIT EAPSDDPQPG TDLVRKTSIT
110 120 130 140 150
SSESLQTVEC SEFQNMAFLQ SLDKEELGEG IKRRMRIKKC KSLENPPLEI
160 170 180 190 200
TKNEATQNIK VEFQDELFKN TPKHSCNSLS PGVEKNCSFE LHDYSFLHSE
210 220 230 240 250
GCNNENNFED KPHDVCLHTE ENSLKLKKEN LRNLAEKDDT RTTTKLLKTE
260 270 280 290 300
KSVIASKLLL EESHLYQNKN NGLTSCLQSE KNKYSVEENN TGRKHRKKMK
310 320 330 340 350
SGKEEKNINL TLSNVCNNSV LVLQENQMGM EGKEAETLEP KKSFLKALRK
360 370 380 390 400
INHNTLPPVD HLCLPKTVGK TSSRHHINAM LQKTLESSLK EDIKNTSESL
410 420 430 440 450
GCKRIEPEKY NKSMISSTVK SPSDGHHMEK RSPRGDLRSE TEESKVSCCR
460 470 480 490 500
TIPMTGKRVW PFYSCARISA QCWKKTSLSD LNYSLLGPLE NVRQHDSIIH
510 520 530 540 550
QMNQTHLPDS KLLQPSLTER TTESSRKEMY DSDLSCLSSV SSVESTVMDI
560 570 580 590 600
KEAMSHDKKT KLEEPSRNGA EVVSNATEDT QLSNITQSLT GNKKRKGNLS
610 620 630 640 650
KLNLTVASQE SQETNNCANK TVHRKVCITK QTLVAPDLVK ILNTGRLTNF
660 670 680 690 700
KIPLLKNKTG KRGAVSARSS EREAYSPLEL LDSLSGVEAK QNRNKENICT
710 720 730 740 750
TSGPQSLNLH SCIAPGQASS HSFYNKNSCT SSSFTKKGYD NKACNHISEP
760 770 780 790 800
GNIISNKESI SMKIENNTFS CDLGYIDQSS FCSKKQEAFV PISSEISGRK
810 820 830 840 850
MTKSISELKL GFPDILKAYE DDVLLIDVIQ DDPELFGISS EGDLSFASEV
860 870 880 890 900
SKISQEPRVS EDQPTADFKH MHLPGKKEPG DLSKEVALLD PGLLKLESCP
910 920 930 940 950
SLSAAKEPQH DPEGAAISLE ATEETVVSGS LEGLSEQARA SDSDAKCISS
960 970 980 990 1000
DKATVMEEQE STHEIFKSKD SRNVESATEC QLATLGPNPL CSSALPVNLS
1010 1020 1030 1040 1050
SHQDVVSTPW INDVRFPGRH SVLQLQNPET CEIFKREKNM GVFQKPLGLL
1060 1070 1080 1090 1100
IPHRYCKLHF NTLRGCERAQ CKFVHVPEQG DEKICMDVFR KYISVNEQRL
1110 1120 1130 1140 1150
LHRAAYIFLE YYRKFPPGIH FSLQVLNDLL ISLLKHCLLK EVFQVVQLSI
1160 1170 1180 1190 1200
MAKMLPALKI LLKIFEYVAA MKLRNAVPAL IEIFCKFIEA GMVPDPEHLN
1210 1220 1230 1240 1250
YIVKLLHQAQ ASQQEISAVL QAKSRLRVRQ LKKNWKCDLD SALSEVETCK
1260 1270 1280 1290 1300
EKSDWTKLGN LYISIKMSCE EFADLQRFCA CVAETLTEDY KEERPGVPFC
1310 1320 1330 1340 1350
EFAETVSKDP QYSEVDKTLL GRIGISAVYF YHRLLLWAKG RKVLDILYEL
1360 1370 1380 1390 1400
KIHFTSLKGL TGPEKEAPRC QIVNVAAEIF IKSGSLDGAI WVLRESEWII
1410 1420 1430 1440 1450
NTPLWPCDRM DVLNRHNLLC TIAHEILGKN LYKQTFEVLR NLPSFQNSQE
1460 1470 1480 1490 1500
MMGVSQSSLL FNELLDACIE SNSLGISSSV AEFMVAKSIP IDFSFLRRLI
1510 1520 1530 1540 1550
TSLGRSCLWL KARAHYKSAL SLGCYPPLEG NLHRKLLLVP SYLSEIEMLL
1560 1570 1580 1590 1600
AMEIFLVSNA SGIQSAGMGA PTQVLQIVLK RCEESKSRSK DEYQAAVERL
1610 1620 1630 1640 1650
VMAARISDPK LFIKHMTVNI NKEQVYSLEH CSALKWLKEN MKWAGKVWLF

TNH
Length:1,653
Mass (Da):185,487
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE33DB431D3631B6C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
HM631980 mRNA Translation: ADK36691.1
AC124778 Genomic DNA No translation available.
AC125374 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS57718.1

NCBI Reference Sequences

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RefSeqi
NP_001186665.1, NM_001199736.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.296421

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000178679; ENSMUSP00000136304; ENSMUSG00000094985

Database of genes from NCBI RefSeq genomes

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GeneIDi
671232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:671232

UCSC genome browser

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UCSCi
uc012hcy.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM631980 mRNA Translation: ADK36691.1
AC124778 Genomic DNA No translation available.
AC125374 Genomic DNA No translation available.
CCDSiCCDS57718.1
RefSeqiNP_001186665.1, NM_001199736.1
UniGeneiMm.296421

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

PTM databases

iPTMnetiE5FYH1
PhosphoSitePlusiE5FYH1

Proteomic databases

PaxDbiE5FYH1
PRIDEiE5FYH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000178679; ENSMUSP00000136304; ENSMUSG00000094985
GeneIDi671232
KEGGimmu:671232
UCSCiuc012hcy.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
375337
MGIiMGI:3779933 Topaz1

Phylogenomic databases

eggNOGiENOG410IGNR Eukaryota
ENOG4111I5N LUCA
GeneTreeiENSGT00390000012495
InParanoidiE5FYH1
OMAiYYRKFPP
OrthoDBi347766at2759
TreeFamiTF338635

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E5FYH1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000094985 Expressed in 4 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR038952 TOPAZ1
IPR029435 TOPAZ1_dom
PANTHERiPTHR35671 PTHR35671, 1 hit
PfamiView protein in Pfam
PF14669 Asp_Glu_race_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPZ1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5FYH1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: February 8, 2011
Last modified: January 16, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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