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Entry version 29 (07 Apr 2021)
Sequence version 2 (25 Apr 2018)
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Protein

Protein TOPAZ1

Gene

TOPAZ1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TOPAZ1Curated
Alternative name(s):
Testis- and ovary-specific PAZ domain-containing protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPAZ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004160951 – 1599Protein TOPAZ1Add BLAST1599

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E5FYH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both adult testis and fetal ovary, mostly in germ cells (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression increases in the ovary during the meiosis prophase I period at 55-65 dpc and decreases until the end of the fetal life and then remains very low in adult ovary. Low expression in testis throughout fetal development.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000004594

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E5FYH0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPIV, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003190_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom
IPR000571, Znf_CCCH

The PANTHER Classification System

More...
PANTHERi
PTHR35671, PTHR35671, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5FYH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAQASGKEV ESDKSAKEKR KVTEASSDDP QPGIDLVRKE SLTSSESFPT
60 70 80 90 100
VECSEFQSMA FLQSLGKERL VEGIKRRIRI KKFKSLESPA LKMTENKATQ
110 120 130 140 150
NSKVEFQDEL YKNTLKYSCN SLSPGVENNS TLKLHDCSCL SHSKDCNDEN
160 170 180 190 200
NLAYKPDGGC MHVPENSSKS KKENPRSLID KTDPSNIPQL LQTEENLMRV
210 220 230 240 250
SQLLLEENDS YLSKNNGMFS CLQSEKNKHS IEESSIGRKS RKRMKVSEKG
260 270 280 290 300
NGMVIEMKFS NMCNKSELML QGNQTGAEGK ETETLEAKKS SLKVLRKVNN
310 320 330 340 350
NTLSPMDPLL SLPETGKKTS PEHYANAVFQ KAVEQLSKEE TKNVSQPLGC
360 370 380 390 400
TSMDPPEDYF KSMKNSLVKS LSDCFPIEKR SSREGLKNEA EESKYSCHRT
410 420 430 440 450
IPMTGKRTWP CYSCARISAQ CWKKASLPQS SRQDDFLRHQ MNQTHLSDSK
460 470 480 490 500
LMLQSSVTET NSASSSIEKL DSNLNCLPSV STVEPTSVVI KEPIVNDDEK
510 520 530 540 550
MKSEELSRSA SEVVSNITED TPLTNVTHNS TGSKKKDRGN LTKLNLMVAS
560 570 580 590 600
QDGQEASNST GKTVHRKACI TKQALVVPDL VKILNTGRLT NFKIPLLKNK
610 620 630 640 650
TEKRKEINAK SSEREVYSPL ELLDSLSGAE VRQSRTKENT VTVTSGPQSL
660 670 680 690 700
SIQHSVIPVQ ASSDSFCSKN SCIIAPSFLK QGNNNKPSSH ISASGHIISN
710 720 730 740 750
KAAGSLTVEN NTFSCDPGCI EKNPTFYSNE QEPFKAVSSE VSGRKMSKNF
760 770 780 790 800
SEIKVGFPDI LKAYEDDVLL IDVIQDDPDL FGVSSEGELS FPSEVPLISQ
810 820 830 840 850
EPNVAEEHQS ADSKHMELPE KKEPSDHLRE LPVPDPGSVK SEICASLSAA
860 870 880 890 900
SEIKHDSKDA NISLGEVTHE TSSNEKPGGL SEQTKSSDLD EKCRFSDKVA
910 920 930 940 950
IREEKETISE VFRSDSKNTE IMVGECHLAA LVSKPLCLPV PLPPLNLSTH
960 970 980 990 1000
QEDTLLNPWM NDFRLPGKHS LLKLQNPEIC EIFKREKNLG VFQKPLGLII
1010 1020 1030 1040 1050
PHRYCKFHFN TIRGCERSQC KFAHVPEQGD EKVCMDVFKK YISISELCLL
1060 1070 1080 1090 1100
QRAANMFMEY YRKFLPGIHF DLQVLNDLLN SLLKHCLLKE VFQIMNLCIM
1110 1120 1130 1140 1150
IKMLPALKIL LKIFEYVATM KLRNAVPALI DMFCKLVEAG MVLDLEHFNY
1160 1170 1180 1190 1200
IVKLLYQVQA SKQEITAVLE MKSRLRMRQF KKNWKCDLEA ALNEIEHCKE
1210 1220 1230 1240 1250
KGDWTKLGNV YLNIKMSCEK FADFQRFCAY IAEILTKDCK EERPGVPFCE
1260 1270 1280 1290 1300
FAETVSKDLQ NSEVDKTLLG RIGISAMYFY HKLLQWSKGR KVLDKLYEKI
1310 1320 1330 1340 1350
HCTSLKGLIG PEKLAPRCQI VNIAAEIFLK SGSLDGAIWV LRESEWIINT
1360 1370 1380 1390 1400
PVWPCDRLDV LNRHNLLCTI AHEILAKSLY RQTFEVLQNL PGFQNSQETV
1410 1420 1430 1440 1450
EVSQYSLLFN KLLDACIESN SLGMSSSVAE FMISKSIPID FSFLRRLITS
1460 1470 1480 1490 1500
LGRSCLWLKA RAHYKSALSL GCYPPLEGNL YRKLLLIPSY LSEIEMLLAI
1510 1520 1530 1540 1550
EIFLVSNASS IQSPGTSTQM LQIVLKRSEE NKSRSKDDYQ AAVERLIMAA
1560 1570 1580 1590
RISDPKLFIK HMTVNVNKEQ VYSLEHCSAL KWLKENMKWG VKVWLFNNR
Length:1,599
Mass (Da):180,026
Last modified:April 25, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B08E9EC095E7CE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324Y → C in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti333V → L in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti797L → M in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti971L → V in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti1289G → R in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti1299 – 1302KIHC → LKIHF in ADK36690 (PubMed:22069478).Curated4
Sequence conflicti1349N → I in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti1463 – 1464HY → PH in ADK36690 (PubMed:22069478).Curated2
Sequence conflicti1476L → S in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti1539Y → H in ADK36690 (PubMed:22069478).Curated1
Sequence conflicti1590 – 1591GV → AG in ADK36690 (PubMed:22069478).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HM631979 mRNA Translation: ADK36690.1
AMGL01044446 Genomic DNA No translation available.
AMGL01044447 Genomic DNA No translation available.
AMGL01044448 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM631979 mRNA Translation: ADK36690.1
AMGL01044446 Genomic DNA No translation available.
AMGL01044447 Genomic DNA No translation available.
AMGL01044448 Genomic DNA No translation available.

3D structure databases

SMRiE5FYH0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000004594

Proteomic databases

PRIDEiE5FYH0

Phylogenomic databases

eggNOGiENOG502QPIV, Eukaryota
HOGENOMiCLU_003190_0_0_1

Family and domain databases

InterProiView protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom
IPR000571, Znf_CCCH
PANTHERiPTHR35671, PTHR35671, 1 hit
PfamiView protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPZ1_SHEEP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5FYH0
Secondary accession number(s): W5P2E5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 25, 2018
Last modified: April 7, 2021
This is version 29 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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