UniProtKB - E5DY33 (E5DY33_HUMAN)
Protein
NADH-ubiquinone oxidoreductase chain 6
Gene
ND6
Organism
Homo sapiens (Human)
Status
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation
Catalytic activityi
- EC:7.1.1.2UniRule annotationARBA annotation
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | TranslocaseUniRule annotation |
Biological process | Electron transport, Respiratory chainUniRule annotation, Transport |
Ligand | NADUniRule annotation, UbiquinoneUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase chain 6UniRule annotation (EC:7.1.1.2UniRule annotation) |
Gene namesi | Name:ND6Imported |
Encoded oni | MitochondrionImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 46 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 53 – 75 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 81 – 104 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 111 – 128 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 148 – 168 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionUniRule annotationImportedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5011938294 | 16 – 174 | NADH-ubiquinone oxidoreductase chain 6Sequence analysisAdd BLAST | 159 |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I subunit 6 family.UniRule annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationFamily and domain databases
InterProi | View protein in InterPro IPR001457, NADH_UbQ/plastoQ_OxRdtase_su6 |
Pfami | View protein in Pfam PF00499, Oxidored_q3, 1 hit |
i Sequence
Sequence statusi: Complete.
E5DY33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY
60 70 80 90 100
MGLMVFXIYL GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV
110 120 130 140 150
GLVLWVKEYD GVVVVVNFNS VGSWMIYEGE GSGLIREDPI GAGALYDYGR
160 170
WLVVVTGWTL FVGVYIVIEI ARGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU733719 Genomic DNA Translation: ADP22372.1 GU733720 Genomic DNA Translation: ADP22385.1 GU733726 Genomic DNA Translation: ADP22463.1 MG182490 Genomic DNA Translation: AXF36860.1 MG182512 Genomic DNA Translation: AXF37146.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU733719 Genomic DNA Translation: ADP22372.1 GU733720 Genomic DNA Translation: ADP22385.1 GU733726 Genomic DNA Translation: ADP22463.1 MG182490 Genomic DNA Translation: AXF36860.1 MG182512 Genomic DNA Translation: AXF37146.1 |
3D structure databases
ModBasei | Search... |
Miscellaneous databases
ChiTaRSi | MT-ND6, human |
Family and domain databases
InterProi | View protein in InterPro IPR001457, NADH_UbQ/plastoQ_OxRdtase_su6 |
Pfami | View protein in Pfam PF00499, Oxidored_q3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E5DY33_HUMAN | |
Accessioni | E5DY33Primary (citable) accession number: E5DY33 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | August 12, 2020 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |