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UniProtKB - E5DK16 (E5DK16_DROME)

Entry version 74 (19 Jan 2022)
Sequence version 1 (08 Feb 2011)
Previous versions | rss
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Protein
Submitted name:

Lipin isoform J

Gene

Lpin

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lipin isoform JImported
Submitted name:
Lipin, isoform JImported (EC:3.1.3.4Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LpinImported
Synonyms:anon-WO0118547.133Imported, dLipinImported, DLpinImported, Dmel\CG8709Imported, DmLpinImported, EP2431Imported, LIPINImported
ORF Names:CG8709Imported, Dmel_CG8709Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0263593, Lpin

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0263593

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0263593, Expressed in capitellum (Drosophila) and 56 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini735 – 890LNS2InterPro annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 108DisorderedSequence analysisAdd BLAST37
Regioni136 – 342DisorderedSequence analysisAdd BLAST207
Regioni435 – 477DisorderedSequence analysisAdd BLAST43
Regioni608 – 653DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi74 – 88Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi164 – 181Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi200 – 214Basic residuesSequence analysisAdd BLAST15
Compositional biasi215 – 229Polar residuesSequence analysisAdd BLAST15
Compositional biasi250 – 273Polar residuesSequence analysisAdd BLAST24
Compositional biasi447 – 466Polar residuesSequence analysisAdd BLAST20
Compositional biasi630 – 653Polar residuesSequence analysisAdd BLAST24

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168260

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036412, HAD-like_sf
IPR026058, LIPIN
IPR031703, Lipin_mid
IPR013209, LNS2
IPR031315, LNS2/PITP

The PANTHER Classification System

More...PANTHERi		PTHR12181, PTHR12181, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16876, Lipin_mid, 1 hit
PF08235, LNS2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00775, LNS2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E5DK16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLGDSGEAF FVEECLEDED EELPANLATS PIPNSFLASR DKANDTMEDI 
        60         70         80         90        100
SGVVTDKNAS EELLLPLPLP RRNSIDFSKE EPKEAVVEGS KFENQVSDYT 
       110        120        130        140        150
QRRHTDNTLE RRNLSEKLKE FTTQKIRQEW AEHEELFQGE KKPADSDSLD 
       160        170        180        190        200
NQSKASNEAE TEKAIPAVIE DTEKEKDQIK PDVNLTTVTT SEATKEVSKS 
       210        220        230        240        250
KTKKRRKKSQ MKKNAQRKNS SSSSLGSAGG GDLPSAETPS LGVSNIDEGD 
       260        270        280        290        300
APISSATNNN NTSSSNDEQL SAPLVTARTG DDSPLSEIPH TPTSNPRLDL 
       310        320        330        340        350
DIHFFSDTEI TTPVGGGGAG SGRAAGGRPS TPIQSDSELE TTMRDNRHVV 
       360        370        380        390        400
TEESTASWKW GELPTPEQAK NEAMSAAQVQ QSEHQSMLSN MFSFMKRANR 
       410        420        430        440        450
LRKEKGVGEV GDIYLSDLDA GSMDPEMAAL YFPSPLSKAA SPPEEDGESG 
       460        470        480        490        500
NGTSLPHSPS SLEEGQKSID SDFDETKQQR DNNRYLDFVA MSMCGMSEQG 
       510        520        530        540        550
APPSDEEFDR HLVNYPDVCK SPSIFSSPNL VVRLNGKYYT WMAACPIVMT 
       560        570        580        590        600
MITFQKPLTH DAIEQLMSQT VDGKCLPGDE KQEAVAQADN GGQTKRYWWS 
       610        620        630        640        650
WRRSQDAAPN HLNNTHGMPL GKDEKDGDQA AVATQTSRPT SPDITDPTLS 
       660        670        680        690        700
KSDSLVNAEN TSALVDNLEE LTMASNKSDE PKERYKKSLR LSSAAIKKLN 
       710        720        730        740        750
LKEGMNEIEF SVTTAYQGTT RCKCYLFRWK HNDKVVISDI DGTITKSDVL 
       760        770        780        790        800
GHILPMVGKD WAQLGVAQLF SKIEQNGYKL LYLSARAIGQ SRVTREYLRS 
       810        820        830        840        850
IRQGNVMLPD GPLLLNPTSL ISAFHREVIE KKPEQFKIAC LSDIRDLFPD 
       860        870        880        890        900
KEPFYAGYGN RINDVWAYRA VGIPIMRIFT INTKGELKHE LTQTFQSSYC 
       910        920        930        940        950
SMTYIVDQLF PPVKLDEASA EFSNFNYWRD PIPDLEIPEL ETALVPPSTK 
       960 
VDMATLRPIP EK
Length:962
Mass (Da):106,626
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B3C94474929B34B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8SXP0Q8SXP0_DROME
Phosphatidate phosphatase
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
1,089Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I0E2I4I0E2I4_DROME
Phosphatidate phosphatase
Lpin anon-WO0118547.133, CG8709-RH, dLipin, DLpin, Dmel\CG8709
1,043Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8DY69A8DY69_DROME
Phosphatidate phosphatase
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
1,035Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JCQ5A0A0B4JCQ5_DROME
Phosphatidate phosphatase
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
1,088Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD00A0A0B4JD00_DROME
Phosphatidate phosphatase
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
1,034Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD27A0A0B4JD27_DROME
Lipin, isoform E
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
1,045Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD31A0A0B4JD31_DROME
Lipin, isoform L
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
992Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JCS1A0A0B4JCS1_DROME
Lipin, isoform G
Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin
1,016Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GU327734 mRNA Translation: ADI80336.1
AE013599 Genomic DNA Translation: ADV37130.1

NCBI Reference Sequences

More...RefSeqi		NP_001188881.1, NM_001201952.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0303580; FBpp0292613; FBgn0263593

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35790

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU327734 mRNA Translation: ADI80336.1
AE013599 Genomic DNA Translation: ADV37130.1
RefSeqiNP_001188881.1, NM_001201952.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		35790

Genome annotation databases

EnsemblMetazoaiFBtr0303580; FBpp0292613; FBgn0263593
GeneIDi35790

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35790
FlyBaseiFBgn0263593, Lpin
VEuPathDBiVectorBase:FBgn0263593

Phylogenomic databases

GeneTreeiENSGT00940000168260

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		35790, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35790

Gene expression databases

BgeeiFBgn0263593, Expressed in capitellum (Drosophila) and 56 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036412, HAD-like_sf
IPR026058, LIPIN
IPR031703, Lipin_mid
IPR013209, LNS2
IPR031315, LNS2/PITP
PANTHERiPTHR12181, PTHR12181, 1 hit
PfamiView protein in Pfam
PF16876, Lipin_mid, 1 hit
PF08235, LNS2, 1 hit
SMARTiView protein in SMART
SM00775, LNS2, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5DK16_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5DK16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: January 19, 2022
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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