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Entry version 46 (26 Feb 2020)
Sequence version 1 (08 Feb 2011)
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Protein
Submitted name:

Cellulose 1,4-beta-cellobiosidase

Gene

Calkro_0861

Organism
Caldicellulosiruptor kronotskyensis (strain DSM 18902 / VKM B-2412 / 2002)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseImported, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CKRO632348:G1GP1-875-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM3 Carbohydrate-Binding Module Family 3
GH48 Glycoside Hydrolase Family 48
GH74 Glycoside Hydrolase Family 74

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cellulose 1,4-beta-cellobiosidaseImported (EC:3.2.1.91Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Calkro_0861Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaldicellulosiruptor kronotskyensis (strain DSM 18902 / VKM B-2412 / 2002)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri632348 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006835 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini797 – 950CBM3InterPro annotationAdd BLAST154
Domaini1002 – 1155CBM3InterPro annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni765 – 796DisorderedSequence analysisAdd BLAST32
Regioni949 – 1001DisorderedSequence analysisAdd BLAST53
Regioni1154 – 1206DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi959 – 993Pro-richSequence analysisAdd BLAST35
Compositional biasi1164 – 1198Pro-richSequence analysisAdd BLAST35

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001798_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEVWRYN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.10, 1 hit
2.130.10.10, 2 hits
2.170.160.10, 1 hit
2.60.40.710, 2 hits
4.10.870.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR023309 Endo-1-4-beta-glucanase_dom2
IPR027390 Endoglucanase_F_dom3
IPR000556 Glyco_hydro_48F
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00942 CBM_3, 2 hits
PF02011 Glyco_hydro_48, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00844 GLHYDRLASE48

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01067 CBM_3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF49384 SSF49384, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172 CBM3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E4SDC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGIALFIA IIFLCTVMYS LTFLVMAESI VTTQKYIWKN VKIEGGGGFI
60 70 80 90 100
TGIVFNPKEK NLVYVRTDIG GAYRSTDGGN TWTQLMNWVS FDEWNLLGVE
110 120 130 140 150
SIATDPVDPN RLYIAAGTYT NSWTNMNGVL LRSKDKGNTF ERTPLPFKLG
160 170 180 190 200
GNMPGRNMGE RLAIDPNNNN ILYLGTREGN GLWKSIDYGV TWKKVENFPN
210 220 230 240 250
PGTYVEDPNC PYDYLNHITG VVWVVFDPTS GKPGEGSKVI YVGVADKNTS
260 270 280 290 300
IYYTKDGGQT WEALPGQPTG LLPQHAKLSS DGMLYITYSN TQGPYNGDYG
310 320 330 340 350
EVWRYNTKTG EWKNISPMPA KDTYFGYGGL AVDAQNPKVV MVAALSSWWP
360 370 380 390 400
DTYIWRSTDG GETWKCIWEW AGYPNRTLHY TMDISAAPWL NFGITNPIPP
410 420 430 440 450
ETSPKLGWMV ATLEIDPFNS DRMLYGTGAT LYGCDDLTKW DKGEKITIKV
460 470 480 490 500
KGIGIEETSV AALVSPPIGP HLFSAIYDIA GFRHDDLEKA PNWTYTQPNM
510 520 530 540 550
GSTTDIDYAE LNPNFMVRVG NVDKTWNPNT NRIGFSYDGG KSWFQGNQEP
560 570 580 590 600
QGMTEGGTVA AAADASVVVW APKGAPVSYS TDNGNTWYQC ANVPSGAIVY
610 620 630 640 650
SDRVNPNKFY AFKDGKFYTS SDKGKTFVQS PASGLPTSGN FKAVPGREGD
660 670 680 690 700
IWLVGNNGMW HSVDGGYTFT KIGNVEEAAS IGFGKPAEGK TYPAIYTYAK
710 720 730 740 750
INGIRGIFRS DDAGASWVRI NDDNNQFGCA NADITGDLRV YGRVFVATNG
760 770 780 790 800
LGIKWGEIAD SATIPTSTPA PTVTATLTPT PTSTATPTPT PSSTPVAGGQ
810 820 830 840 850
IKVLYANKET NSTTNTIRPW LKVVNTGSSS IDLSRVTIRY WYTVDGDKAQ
860 870 880 890 900
SAISDWAQIG ASNVTFKFVK LSSSVSGADY YLEIGFKSGA GQLQAGKDTG
910 920 930 940 950
EIQIRFNKSD WSNYNQGNDW SWMQSMTNYG ENTKVTAYID GVLVWGQEPS
960 970 980 990 1000
GATATPTPTA TPTPTPSPTP TPTPTVTPTP TPTPTPTVTA TPTPTPSSTP
1010 1020 1030 1040 1050
VAGGQIKVLY ANKETNSTTN TIRPWLKVVN TGSSSIDLSR VTIRYWYTVD
1060 1070 1080 1090 1100
GDKAQSAISD WAQIGASNVT FKFVKLSSSV SGADYYLEIG FKSGAGQLQA
1110 1120 1130 1140 1150
GKDTGEIQIR FNKSDWSNYN QGNDWSWMQS MTNYGENTKV TAYIDGVLVW
1160 1170 1180 1190 1200
GQEPSGATAT PTPTATPTPT PSPTPTPTPT VTPTPTPTPT PTVTATPTPT
1210 1220 1230 1240 1250
PSSTPGVLGE YGQRFMWLWN KIHDPANGYF NQDGIPYHSV ETLICEAPDY
1260 1270 1280 1290 1300
GHLTTSEAFS YYVWLEAVYG KLTGDWSKFK TAWDTLEKYM IPSAEDQPMR
1310 1320 1330 1340 1350
SYDPNKPATY AGEWETPDKY PSPLEFNVPV GKDSLHNELV STYGSTLMYG
1360 1370 1380 1390 1400
MHWLMDVDNW YGYGKRGDGV SRASFINTFQ RGPEESVWET VPHPSWEEFK
1410 1420 1430 1440 1450
WGGPNGFLDL FIKDQNYSKQ WRYTDAPDAD ARAIQATYWA KVWAKEQGKF
1460 1470 1480 1490 1500
NDISSYVAKA AKMGDYLRYA MFDKYFKPLG CQDKNAAGGT GYDSAHYLLS
1510 1520 1530 1540 1550
WYYAWGGALD GAWSWKIGSS HVHFGYQNPM AAWALANDSD MKPKSPNGAS
1560 1570 1580 1590 1600
DWAKSLKRQI EFYRWLQSAE GAIAGGATNS WNGRYEKYPA GTATFYGMAY
1610 1620 1630 1640 1650
EPNPVYHDPG SNTWFGFQAW SMQRVAEYYY VTGDKDAGAL LEKWVSWVKS
1660 1670 1680 1690 1700
VVKLNSDGTF AIPSTLDWSG QPDTWNGAYT GNSNLHVKVV DYGTDLGITA
1710 1720 1730 1740 1750
SLANALLYYS AGTKKYGVFD EGAKNLAKEL LDRMWKLYRD EKGLSAPEKR
1760 1770 1780 1790 1800
ADYKRFFEQE VYIPAGWTGK MPNGDVIKSG VKFIDIRSKY KQDPDWPKLE
1810 1820 1830
AAYKSGQAPE FRYHRFWAQC DIAIANATYE ILFGNQ
Length:1,836
Mass (Da):202,600
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D750841A27893B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002330 Genomic DNA Translation: ADQ45737.1

NCBI Reference Sequences

More...
RefSeqi
WP_013429878.1, NC_014720.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADQ45737; ADQ45737; Calkro_0861

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ckn:Calkro_0861

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|632348.3.peg.915

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002330 Genomic DNA Translation: ADQ45737.1
RefSeqiWP_013429878.1, NC_014720.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
GH48 Glycoside Hydrolase Family 48
GH74 Glycoside Hydrolase Family 74

Genome annotation databases

EnsemblBacteriaiADQ45737; ADQ45737; Calkro_0861
KEGGickn:Calkro_0861
PATRICifig|632348.3.peg.915

Phylogenomic databases

HOGENOMiCLU_001798_0_0_9
OMAiGEVWRYN

Enzyme and pathway databases

BioCyciCKRO632348:G1GP1-875-MONOMER

Family and domain databases

Gene3Di1.50.10.10, 1 hit
2.130.10.10, 2 hits
2.170.160.10, 1 hit
2.60.40.710, 2 hits
4.10.870.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR023309 Endo-1-4-beta-glucanase_dom2
IPR027390 Endoglucanase_F_dom3
IPR000556 Glyco_hydro_48F
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00942 CBM_3, 2 hits
PF02011 Glyco_hydro_48, 1 hit
PRINTSiPR00844 GLHYDRLASE48
SMARTiView protein in SMART
SM01067 CBM_3, 2 hits
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49384 SSF49384, 2 hits
PROSITEiView protein in PROSITE
PS51172 CBM3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE4SDC8_CALK2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E4SDC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 26, 2020
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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