Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate lyase

Gene

argH

Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciHHYD656519:G1GOZ-733-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Halsa_0734Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
Proteomesi
  • UP000007434 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi656519.Halsa_0734

Structurei

3D structure databases

ProteinModelPortaliE4RMW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 303Lyase_1InterPro annotationAdd BLAST298
Domaini366 – 438ASL_C2InterPro annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 86Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

E4RMW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWGGRFEG GISEKMDRFN ASLPFDINLL EYDIEGSLAH VKMLGREGII
60 70 80 90 100
SESEAEKIIL GLKELKAELL EELEKDKLDL SQAEDIHSLV EMRLTEKIGA
110 120 130 140 150
VAGKLHTGRS RNDQVALDMR LYLRDQTADI KALIKAFMKV LLELAGEHTE
160 170 180 190 200
TVMPGYTHLQ RAQALTFGHH LLAYYFKLKR DYERFEDAEK RINVSPLGSG
210 220 230 240 250
ALAGSSFKLD REFTAKELGF ARACENSLDG VSDRDFVLEF LAVASNLMLH
260 270 280 290 300
LSRLSEEIIL WNAAEFSFIE LADQYTTGSS IMPQKKNPDL AELVRGKSGR
310 320 330 340 350
VIGSLNQLMI TIKGLPLAYN KDLQEDKEGL FDSVATVKLI LELYPEMLKT
360 370 380 390 400
MKVNKEKMKK AAETGFLNAT ELADYLAAEG IPFRKAHQIV GKAVLFAAEK
410 420 430 440 450
DKELEQLNLE DWQSLFSGII EVDQKKLKEI LAVEAAVNSH ATKGGPAFKE
460
TKRVIAEERS FFDD
Length:464
Mass (Da):52,036
Last modified:February 8, 2011 - v1
Checksum:iD20B313747EAFCB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002304 Genomic DNA Translation: ADQ14184.1
RefSeqiWP_013405276.1, NC_014654.1

Genome annotation databases

EnsemblBacteriaiADQ14184; ADQ14184; Halsa_0734
KEGGihas:Halsa_0734

Similar proteinsi

Entry informationi

Entry nameiE4RMW7_HALHG
AccessioniPrimary (citable) accession number: E4RMW7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health