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UniProtKB - E3VWI7 (PNTE_STRAE)
Protein
Pentalenolactone D synthase
Gene
pntE
Organism
Streptomyces arenae
Status
Functioni
Catalyzes the flavin-dependent Baeyer-Villiger oxidation of 1-deoxy-11-oxopentalenic acid to pentalenolactone D in the biosynthesis of pentalenolactone antibiotic.
1 PublicationCatalytic activityi
- EC:1.14.13.1701 Publication
Cofactori
FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication
: pentalenolactone biosynthesis Pathwayi
This protein is involved in the pathway pentalenolactone biosynthesis, which is part of Antibiotic biosynthesis.1 PublicationView all proteins of this organism that are known to be involved in the pathway pentalenolactone biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 108 | FADBy similarity | 1 | |
Binding sitei | 152 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Sitei | 376 | Transition state stabilizerSequence analysis | 1 | |
Binding sitei | 491 | FAD; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 60 – 61 | FADBy similarity | 2 | |
Nucleotide bindingi | 82 – 83 | FADBy similarity | 2 | |
Nucleotide bindingi | 90 – 91 | FADBy similarity | 2 | |
Nucleotide bindingi | 102 – 103 | FADBy similarity | 2 |
GO - Molecular functioni
- 1-deoxy-11-oxopentalenate oxygenase activity Source: UniProtKB-EC
- FAD binding Source: UniProtKB
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: UniProtKB
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- pentalenolactone biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Antibiotic biosynthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
UniPathwayi | UPA00974 |
Names & Taxonomyi
Protein namesi | Recommended name: Pentalenolactone D synthase (EC:1.14.13.170)Alternative name(s): Pentalenolactone biosynthesis protein E |
Gene namesi | Name:pntE |
Organismi | Streptomyces arenae |
Taxonomic identifieri | 29301 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422004 | 1 – 589 | Pentalenolactone D synthaseAdd BLAST | 589 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAD-binding monooxygenase family.Curated
Family and domain databases
Gene3Di | 3.50.50.60, 3 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf |
SUPFAMi | SSF51905, SSF51905, 1 hit |
i Sequence
Sequence statusi: Complete.
E3VWI7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLEAVREKY RQERDKRGVG RTYQFARGDF SRYARDPYTE RREREPLTDE
60 70 80 90 100
VDVAVVGAGI GGLLTGARLR EETGLERIRL IDEAGDVGGT WYWNRFPGVR
110 120 130 140 150
CDVESYVYMP LLEEIGTIPT EKYSTGPEIF AHLQRIAHRY GLYRDALFQT
160 170 180 190 200
TVTELRWDEA AARWLVSTDR GDLFRARYVA MSIGLMHRPK LPGLPGLETF
210 220 230 240 250
AGHSFHTSRW DFGYTGGDST GGLTGLKDKR VGVIGTGSTT VQLAPHLAEW
260 270 280 290 300
AERLYIFQRT PAAVDVRGNR PTPPGWADGL DAGWQQRRME NFHALTSGIP
310 320 330 340 350
QDEDLVQDRW TQTTAELATA ILPTGDTGGD PKERALAAER ADFRKMEELR
360 370 380 390 400
ARIDSVVTDP ATAAALKPYY RVYCKRPCFH DGYLQTFNRP NVTLVDTQGQ
410 420 430 440 450
GVERLTASGV VANGREYPVD CLIFATGYEH EFAVPYTERA GYDIVGRGGV
460 470 480 490 500
RLSEKWAQGA HTLHGLQVHG FPNCFILSKV QAGRHVNIAY MLGEQTRHLA
510 520 530 540 550
HIVKCVEERG HRVVEASEAG EKEWVEEILR LASGDLDFLE NCTPGLYNNE
560 570 580
GDPGGLPLLN SSYGGGSVEF VNILRRWREA GDLAGLELR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ292065 Genomic DNA Translation: ADO85575.1 |
Genome annotation databases
KEGGi | ag:ADO85575 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ292065 Genomic DNA Translation: ADO85575.1 |
3D structure databases
SMRi | E3VWI7 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ag:ADO85575 |
Enzyme and pathway databases
UniPathwayi | UPA00974 |
Family and domain databases
Gene3Di | 3.50.50.60, 3 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf |
SUPFAMi | SSF51905, SSF51905, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PNTE_STRAE | |
Accessioni | E3VWI7Primary (citable) accession number: E3VWI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2013 |
Last sequence update: | January 11, 2011 | |
Last modified: | September 29, 2021 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families