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Entry version 62 (29 Sep 2021)
Sequence version 2 (19 Oct 2011)
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Protein

Non-structural protein 8

Gene
N/A
Organism
Porcine reproductive and respiratory syndrome virus (PRRSV)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation, Nucleotidyltransferase, RNA-directed RNA polymeraseImportedARBA annotation, Transferase
Biological processViral RNA replicationARBA annotation
LigandATP-bindingARBA annotation, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-structural protein 8ARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
ORF1ab polyproteinARBA annotation
RNA-directed RNA polymeraseARBA annotation
Replicase polyprotein 1abARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorcine reproductive and respiratory syndrome virus (PRRSV)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28344 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesArnidovirineaeArteriviridaeunclassified Arteriviridae
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSus scrofa (Pig) [TaxID: 9823]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000150270 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E3V2B6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini389 – 523RdRp catalyticInterPro annotationAdd BLAST135
Domaini644 – 707AV ZBDInterPro annotationAdd BLAST64
Domaini764 – 1045(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST282

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21410, 1B_av_Nsp10-like, 1 hit
cd21160, NendoU_av_Nsp11-like, 1 hit
cd21166, NTD_av_Nsp11-like, 1 hit
cd21405, ZBD_av_Nsp10-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043502, DNA/RNA_pol_sf
IPR037227, EndoU-like
IPR043609, NendoU_nidovirus
IPR044348, NSP10_1B_Av
IPR027355, NSP10_Av_ZBD
IPR044320, NSP11_Av_N
IPR044314, NSP11_NendoU_Av
IPR027417, P-loop_NTPase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19215, CoV_NSP15_C, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF142877, SSF142877, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51652, AV_ZBD, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

E3V2B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FKLLAASGLT RCGRGGLVVT ETAVKIVKFH NRTFTLGPVN LKVASEVELK
60 70 80 90 100
DAVEHNQHPV ARPVDGGVVL LRSAVPSLID VLISGADASP KLLARHGPGN
110 120 130 140 150
TGIDGTLWDF EAEATKEEVA LSAQIIQACD IRRGDAPEIG LPYKLYPVRG
160 170 180 190 200
NPERVKGVLQ NTRFGDIPYK TPSDTGSPVH AAACLTPNAT PVTDGRSVLA
210 220 230 240 250
TTMPSGFELY VPTIPASVLD YLDSRPDCPK QLTEHGCEDA ALRDLSKYDL
260 270 280 290 300
STQGFVLPGV LRLVRKYLFA HVGKCPPVHR PSTYPAKNSM AGINGNRFPT
310 320 330 340 350
KDIQSVPEID VLCAQAVREN WQTVTPCTLK KQYCGKKKTR TILGTNNFIA
360 370 380 390 400
LAHRAALSGV TQGFMKKAFN SPIALGKNKF KELQAPVLGR CLEADLASCD
410 420 430 440 450
RSTPAIVRWF AANLLYELAC AEEHLPSYVL NCCHDLLVTQ SGAVTKRGGL
460 470 480 490 500
SSGDPITSVS NTIYSLVIYA QHMVLSYFKS GHPHGLLFLQ DQLKFEDMLK
510 520 530 540 550
VQPLIVYSDD LVLYAESPSM PNYHWWVEHL NLMLGFQTDP KKTTITDSPS
560 570 580 590 600
FLGCRIINGR QLVPNRDRIL AALAYHMKAS NVSKYYASAA AILMDSCACL
610 620 630 640 650
EYDPEWFEEL VVGIAQCARK DGYSFPGPPF FLSMWEKLRS NHEGKKSRMC
660 670 680 690 700
GYCGAPAPYA TACGLDVCVY HTHFHQHCPV IIWCGHPAGS GSCSECEPPL
710 720 730 740 750
GKGTSPLDEV LEQVPYKPPR TVIMHVEQGL TPLDPGRYQT RRGLVSVRRG
760 770 780 790 800
IRGNEVDLPD GDYASTALLP TCKEINMVAV ASNVLRSRFI IGPPGAGKTH
810 820 830 840 850
WLLQQVQDGD VIYTPTHQTM LDMIRALGTC RFNVPAGTTL QFPAPSRTGP
860 870 880 890 900
WVRILAGGWC PGKNSFLDEA AYCNHLDVLR LLSKTTLTCL GDFKQLHPVG
910 920 930 940 950
FDSHCYVFDI MPQTQLKTIW RFGQNICDAI QPDYRDKLMS MVNTTRVTHV
960 970 980 990 1000
EKPVRYGQVL TPYHRDREDG AITIDSSQGA TFDVVTLHLP TKDSLNRQRA
1010 1020 1030 1040 1050
LVAITRARHA IFVYDPHRQL QSMFDLPAKG TPVNLAVHRD EQLIVLDRNN
1060 1070 1080 1090 1100
REITVAQALG NGDKFRATDK RVVDSLRAIC ADLEGSSSPL PKVAHNLGFY
1110 1120 1130 1140 1150
FSPDLTQFAK LPAELAPHWP VVTTQNNERW PDRLVASLRP IHKYSRACIG
1160 1170 1180 1190 1200
AGYMVGPSVF LGTPGVVSYY LTKFVRGEAQ VLPETVFSTG RIEVDCREYL
1210 1220 1230 1240 1250
DDRERVVAES LPHAFIGDVK GTTVGGCHHV TSKYLPRFLP KESVAVVGVS
1260 1270 1280 1290 1300
SPGKAAKAVC TLTDVYLPDL EAYLHPETQS RCWKVMLDFK EVRLMVWKDK
1310 1320 1330 1340 1350
TAYFQLEGRH FTWYQLASYA SYIRVPVNST VYLDPCMGPA LCNRRVVGST
1360 1370 1380 1390 1400
HWGADLAVTP YDYGAKIILS SAYHGEMPPG YKILACAEFS LDDPVRYKHT
1410 1420 1430 1440 1450
WGFESDTAYL YEFTGNGEDW EDYNDAFRAR QKGKIYKANA TSMRFHFPPG
1460
PVIEPTLGLN
Length:1,460
Mass (Da):161,557
Last modified:October 19, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FCE3876E1064778
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HM853673 Genomic RNA Translation: ADO33722.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM853673 Genomic RNA Translation: ADO33722.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DA1X-ray2.75A/B1085-1307[»]
SMRiE3V2B6
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

CDDicd21410, 1B_av_Nsp10-like, 1 hit
cd21160, NendoU_av_Nsp11-like, 1 hit
cd21166, NTD_av_Nsp11-like, 1 hit
cd21405, ZBD_av_Nsp10-like, 1 hit
Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043502, DNA/RNA_pol_sf
IPR037227, EndoU-like
IPR043609, NendoU_nidovirus
IPR044348, NSP10_1B_Av
IPR027355, NSP10_Av_ZBD
IPR044320, NSP11_Av_N
IPR044314, NSP11_NendoU_Av
IPR027417, P-loop_NTPase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF19215, CoV_NSP15_C, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit
SUPFAMiSSF142877, SSF142877, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51652, AV_ZBD, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE3V2B6_PRRSV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E3V2B6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: October 19, 2011
Last modified: September 29, 2021
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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