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Protein

Cyanide hydratase

Gene

chy

Organism
Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can also transform some nitriles like 2-cyanopyridine and fumaronitrile.
Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants. Can also transform some nitriles like 2-cyanopyridine and fumaronitrile.UniRule annotation1 Publication

Catalytic activityi

Formamide = cyanide + H2O.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptorPROSITE-ProRule annotation1
Active sitei128PROSITE-ProRule annotation1
Active sitei163NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Cyanide hydratase1 PublicationUniRule annotation (EC:4.2.1.66UniRule annotation1 Publication)
Short name:
CHT1 PublicationUniRule annotation
Alternative name(s):
Cyanide-degrading nitrilaseUniRule annotation
Formamide hydrolyaseUniRule annotation
Gene namesi
Name:chy1 Publication
Synonyms:NitPt1 Publication
ORF Names:PTT_13066
OrganismiPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
Taxonomic identifieri861557 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
Proteomesi
  • UP000001067 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004400361 – 366Cyanide hydrataseAdd BLAST366

Expressioni

Inductioni

By cyanide.UniRule annotation

Interactioni

Subunit structurei

Oligomer of dimers, forming left-handed helical fibers.UniRule annotation

Protein-protein interaction databases

STRINGi861557.XP_003301539.1

Structurei

3D structure databases

ProteinModelPortaliE3RV84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 285CN hydrolasePROSITE-ProRule annotationAdd BLAST280

Sequence similaritiesi

Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0805 Eukaryota
COG0388 LUCA
KOiK10675
OrthoDBiEOG092C351H

Family and domain databases

Gene3Di3.60.110.10, 1 hit
HAMAPiMF_03224 CN_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
IPR037544 CN_hydrolase
IPR000132 Nitrilase/CN_hydratase_CS
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit
PS00920 NITRIL_CHT_1, 1 hit
PS00921 NITRIL_CHT_2, 1 hit

Sequencei

Sequence statusi: Complete.

E3RV84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLTKYKAAA VTSEPCWFDL TAGVQKTIDF INEAGAAGCK LVAFPEVWIP
60 70 80 90 100
GYPYWMWKVN YQQSLPLLKK YRENSLPIDS EEFRKIRRAA RDNQIHVSLG
110 120 130 140 150
FSEIDHATCY LTQTLIDPTG EVINHRRKIK PTHVEKLVYG DGAGDTFKSV
160 170 180 190 200
TQTELGRLGQ LNCWENMNPF LKALNVSEGE QIHIAAWPVY PGKETLNYPD
210 220 230 240 250
PATNVAEPAS DLVTPAYAIE TGTWTLAPFQ RLSKEGLKIN TPEGIEPETD
260 270 280 290 300
PSTYNGHARI YRPDGSLYAK PDKDFDGLMF VDIDLNECQL TKALADFSGH
310 320 330 340 350
YMRPDLIRLL VDTRRKELVT EADPHGGITS YSTRQRLGLD VLLDSDVQKQ
360
KKSGASDLGA TNALAY
Length:366
Mass (Da):40,941
Last modified:January 11, 2011 - v1
Checksum:i6776B6406CF895FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN875502 Genomic DNA Translation: CTQ87268.1
GL535250 Genomic DNA Translation: EFQ90364.1
RefSeqiXP_003301539.1, XM_003301491.1

Genome annotation databases

EnsemblFungiiEFQ90364; EFQ90364; PTT_13066
KEGGipte:PTT_13066

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN875502 Genomic DNA Translation: CTQ87268.1
GL535250 Genomic DNA Translation: EFQ90364.1
RefSeqiXP_003301539.1, XM_003301491.1

3D structure databases

ProteinModelPortaliE3RV84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi861557.XP_003301539.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFQ90364; EFQ90364; PTT_13066
KEGGipte:PTT_13066

Phylogenomic databases

eggNOGiKOG0805 Eukaryota
COG0388 LUCA
KOiK10675
OrthoDBiEOG092C351H

Family and domain databases

Gene3Di3.60.110.10, 1 hit
HAMAPiMF_03224 CN_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
IPR037544 CN_hydrolase
IPR000132 Nitrilase/CN_hydratase_CS
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit
PS00920 NITRIL_CHT_1, 1 hit
PS00921 NITRIL_CHT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHT_PYRTT
AccessioniPrimary (citable) accession number: E3RV84
Secondary accession number(s): A0A0P1DJ02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: January 11, 2011
Last modified: April 25, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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