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Entry version 45 (16 Oct 2019)
Sequence version 1 (11 Jan 2011)
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Protein

TPR_REGION domain-containing protein

Gene

CRE_15370

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TPR_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CRE_15370Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31234 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei91 – 108HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
31234.CRE15370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini514 – 732TPR_REGIONInterPro annotationAdd BLAST219

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni138 – 194DisorderedSequence analysisAdd BLAST57
Regioni228 – 504DisorderedSequence analysisAdd BLAST277

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 174PolarSequence analysisAdd BLAST16
Compositional biasi228 – 266PolyampholyteSequence analysisAdd BLAST39
Compositional biasi267 – 284AcidicSequence analysisAdd BLAST18
Compositional biasi285 – 315PolyampholyteSequence analysisAdd BLAST31
Compositional biasi316 – 365AcidicSequence analysisAdd BLAST50
Compositional biasi366 – 407PolyampholyteSequence analysisAdd BLAST42
Compositional biasi416 – 455PolyampholyteSequence analysisAdd BLAST40
Compositional biasi456 – 492AcidicSequence analysisAdd BLAST37

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3696 Eukaryota
COG3555 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E3MCH3

Identification of Orthologs from Complete Genome Data

More...
OMAi
GNDDVHL

Database of Orthologous Groups

More...
OrthoDBi
395866at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits
2.60.120.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007803 Asp/Arg/Pro-Hydrxlase
IPR039038 ASPH
IPR027443 IPNS-like
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR12366 PTHR12366, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05118 Asp_Arg_Hydrox, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E3MCH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYASSAQCCK NTDSPYGSVK LRHVNYGEEG RPLSSYNRLS RRFNRETVPA
60 70 80 90 100
FPDLATAYYE NYSGVNPVLT VALTPVPKVD YSVTKGGART WIVLLVFILL
110 120 130 140 150
CSSLYTIFSA KDAGDSHHDL TGRTSVDDDD VPAYTHAEAA ANDDNDDDDD
160 170 180 190 200
DEPPQPSPRA SKKQETTQQK SAPAPPPVMD SDDEDDEESN EHTLGGRLFA
210 220 230 240 250
GLRKKITDRL NEVIFEFSIF EKNRYHSQFQ KSVKEEPKNS KSDQILNPRE
260 270 280 290 300
LRKLKRQQKN VKVEVKEEED DDDDDDDDDD VEEAAPQEPS RKQKANNQKD
310 320 330 340 350
DKKEKHKKYQ PVKEEPDLDD DDDDDDDDDD DDNDDDDDKD DGKDGDKDDD
360 370 380 390 400
DNDDDDDDDD DDDNEDDGKN KKKSSVESKS DKKVEEKNDD DDEPHISHKE
410 420 430 440 450
AQRLRRQHLR ESRNRPRHGG KRECIHQDCP GHESLKPRKS LLIQKKKKSM
460 470 480 490 500
VEKILDDEYD DDEDDDDNEE ERNENIREDD DDDDDDDDDE RLTDRESSNS
510 520 530 540 550
YKRHAITTKE EIGFRDILDR ADNLVEKHQY DEAMELFDHV IAVYPSSTRA
560 570 580 590 600
YFGKARAYDI RGEIEADETD RDKAIEIYEK ILQNSAVPDA LFRQAAQRLI
610 620 630 640 650
EKTRFRGQLH KTLNAHRHFI DRFPEELSLQ TDFAISFVMM KRYEDARTVL
660 670 680 690 700
RNVLANDPNH VIALAYYGYI LKAHDDKVEQ GVALMRKSLK LADNEITDPK
710 720 730 740 750
FYYQLGHGLT ALGKKSEADA VYQKAAQMGV FMTAQQRSLY NIEGLTGRAW
760 770 780 790 800
WSMDQTPYSK FLKTVERQWA TIRQEGMEVL KDCSDCWLDH NQQLVIDGQW
810 820 830 840 850
KYFPIMSEQH FVKSSCERMP QTCLILQEFA SSSNASKSEM YLSVLSSGAS
860 870 880 890 900
ILPHCGPTNY HLQAHLGLVS PSEARIRVGN ETKGWRSGKF IIYDDSFEHE
910 920 930
LQFDGASSSS FRLVLILQLW HPEVQPHQRV LSFLT
Length:935
Mass (Da):107,528
Last modified:January 11, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47A1B436A3AE77B0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS268434 Genomic DNA Translation: EFO98167.1

NCBI Reference Sequences

More...
RefSeqi
XP_003106225.1, XM_003106177.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
CRE15370; CRE15370; WBGene00058667

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9807847

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS268434 Genomic DNA Translation: EFO98167.1
RefSeqiXP_003106225.1, XM_003106177.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi31234.CRE15370

Genome annotation databases

EnsemblMetazoaiCRE15370; CRE15370; WBGene00058667
GeneIDi9807847

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9807847

Phylogenomic databases

eggNOGiKOG3696 Eukaryota
COG3555 LUCA
InParanoidiE3MCH3
OMAiGNDDVHL
OrthoDBi395866at2759

Family and domain databases

Gene3Di1.25.40.10, 2 hits
2.60.120.330, 1 hit
InterProiView protein in InterPro
IPR007803 Asp/Arg/Pro-Hydrxlase
IPR039038 ASPH
IPR027443 IPNS-like
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR12366 PTHR12366, 1 hit
PfamiView protein in Pfam
PF05118 Asp_Arg_Hydrox, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE3MCH3_CAERE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E3MCH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: October 16, 2019
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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