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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei228PROSITE-ProRule annotation1
Active sitei423PROSITE-ProRule annotation1
Active sitei481PROSITE-ProRule annotation1

GO - Molecular functioni

  • serine-type carboxypeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PGTG_18559
OrganismiPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Taxonomic identifieri418459 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaePuccinia
Proteomesi
  • UP000008783 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PGTG_18559

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 559LumenalSequence analysis
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 656CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000411942? – 656Pheromone-processing carboxypeptidase KEX1
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5297.EFP92780

Structurei

3D structure databases

SMRiE3L8A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 42Poly-Ser6
Compositional biasi53 – 56Poly-Thr4
Compositional biasi62 – 65Poly-Lys4
Compositional biasi607 – 611Poly-His5

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiE3L8A5
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E3L8A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFQSATTR QGLHRRNMNS ETPQSEFIQR LRRSPPSESS SSTPSSSTTT
60 70 80 90 100
SSTTTTSNTS GKKKKTAPSA SDFYVPSLPG QPKDSQLILY AGHLSFSPPD
110 120 130 140 150
TTIEPEKDSY GFFFLNKARH IANRPVLLVW LNGGPGCSSF DGSLMEVGPL
160 170 180 190 200
RMVLKGDGTL KEVDAAWNEY ANMLFIDQPT GTGYSYGPKP NYVHELDVSS
210 220 230 240 250
ANLVNLLARF FKIFPEYQQM DLYICGESFA GQYIPYLAQA ILDTNIISAP
260 270 280 290 300
LKGIMIGNGW IDPINQYLAY PEFAFKVGLV NPSSKAADLV NEELKKCTEW
310 320 330 340 350
IDSNSTTPIH IEACEGILSA ITDSTVQTVN SQKMCLNMYD VRLVDSYPAC
360 370 380 390 400
GLTWPPDLAD ITPYLSRTDV KQALHAQDHA ADWVECEAKV GNNFWAKTSQ
410 420 430 440 450
PSVTLFPKLL DKIKILLFSG DQDLICCHTG TERMIDHLTW AGHQGWTSQA
460 470 480 490 500
INQPWKVNGS YAGLWKEERN LTYVLVANAS HMAPYDVPYV TQDMLVRFLG
510 520 530 540 550
IDVMTAAGPA AQITSRIGEE TATKVNRVVM NETKLGQEGS GTTGLAMTSG
560 570 580 590 600
PVHDENYYNA SSAMLFLTLV GLVVGLIFFV RRRLRRDGHG DFAHHPSDET
610 620 630 640 650
EIILKNHHHH HLSPDSSLPR SARDRQFQPV PTDDLDDHHL HPNLPSNNTS

YQDLPR
Length:656
Mass (Da):72,697
Last modified:October 3, 2012 - v2
Checksum:i0FD95B1854B5F6CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS178373 Genomic DNA Translation: EFP92780.2
RefSeqiXP_003337199.2, XM_003337151.2

Genome annotation databases

EnsemblFungiiEFP92780; EFP92780; PGTG_18559
GeneIDi10542492
KEGGipgr:PGTG_18559

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS178373 Genomic DNA Translation: EFP92780.2
RefSeqiXP_003337199.2, XM_003337151.2

3D structure databases

SMRiE3L8A5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5297.EFP92780

Protein family/group databases

MEROPSiS10.007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFP92780; EFP92780; PGTG_18559
GeneIDi10542492
KEGGipgr:PGTG_18559

Organism-specific databases

EuPathDBiFungiDB:PGTG_18559

Phylogenomic databases

InParanoidiE3L8A5
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_PUCGT
AccessioniPrimary (citable) accession number: E3L8A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 3, 2012
Last modified: December 20, 2017
This is version 40 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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