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Entry version 52 (16 Jan 2019)
Sequence version 2 (03 Oct 2012)
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Protein

Mucin-22

Gene

MUC22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-22
Alternative name(s):
Panbronchiolitis-related mucin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC22
Synonyms:G4, PBMUCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000261272.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:39755 MUC22

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613917 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_E2RYF6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 1660ExtracellularSequence analysisAdd BLAST1634
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1661 – 1681HelicalSequence analysisAdd BLAST21
Topological domaini1682 – 1773CytoplasmicSequence analysisAdd BLAST92

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100507679

Open Targets

More...
OpenTargetsi
ENSG00000261272

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MUC22

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041047027 – 1773Mucin-22Add BLAST1747

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E2RYF6

PRoteomics IDEntifications database

More...
PRIDEi
E2RYF6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
15279

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E2RYF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E2RYF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung by serous cells of the submucosal gland (at protein level). Detected in the placenta, lung and testis.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by poly(I:C).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000261272 Expressed in 10 organ(s), highest expression level in esophagus mucosa

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000455906

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E2RYF6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 1514124 X 10 AA approximate repeatsAdd BLAST1362

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 1649Thr-richAdd BLAST1622

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KGW0 Eukaryota
ENOG4110RWV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164570

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E2RYF6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTEETEN

Database of Orthologous Groups

More...
OrthoDBi
1320016at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028199 Mucin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14654 Epiglycanin_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

E2RYF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGNISPAF WFLWLLLFGL LGPSSENTTA FTKGSDTTTA SITGSETTMA
60 70 80 90 100
STMASTSALT TGSKITTDST TGSETTSAST MASTAAFTTG SETNTASTTD
110 120 130 140 150
SGTTIASTRT FTTGSDTTTG STAGSETIVA STTVSGTTTT FTIASTTVPE
160 170 180 190 200
TTMASSTTST AGSEKTMASS IISETTMAST TGSETATVST TGSETTTTST
210 220 230 240 250
ASSEATKVST TGSETTTAST AGSETTTTST SMAGSEATTT STADSKVITA
260 270 280 290 300
SSMSSETTVA PAAGSNTTTA STTGSETTTI LIKASETTTA STAGSETTTP
310 320 330 340 350
SPTGSQTTIV SISGSEITTT STAGSENTTV SSAGSGTTTA SMAGSETTVS
360 370 380 390 400
TAGSETTTVS ITGTETTMVS AMGSETTTNS TTSSETTVTS TAGSETTTVS
410 420 430 440 450
TVGSETTTAY TADSETTAAS TTGSEMTTVF TAGSETITPS TAGSETTTVS
460 470 480 490 500
TAGSETTTVS TTGSETTTAS TAHSETTAAS TMGSETTKVS TAGSETTVST
510 520 530 540 550
AGSETTAAST EDSETNTAFT EDSKTTTAST TGFETTAAST TGSEPTMAST
560 570 580 590 600
MGSETTMAST IGPETTKVST ASSEVTTVFA AGSETIRAST VGSETTTVST
610 620 630 640 650
TGSETTTASI MGSETSTDST TGSETTTAST EGSETTTAST EGSEATTVST
660 670 680 690 700
TGSETTTVSI TDSETTTTCT EGSEMTAVST TVFETTTAST EGSEITIAST
710 720 730 740 750
SDSETTTAST EGSETTTVTT AGSETKTAYT TGSETTTASN TGLETTTVFT
760 770 780 790 800
IGSDTTTAST EGSETTAVSA TGSEMTTVST EGSENTTVST TGSETTTVST
810 820 830 840 850
TGLETTTTST EGSEMTTVST TGAETTTDST EGSGTTAAST AGSETTTVST
860 870 880 890 900
ADSENTTAST ADSETTSAST TGSETTTAST TSSETTTAST EGSETTTVST
910 920 930 940 950
TDSETTMVST TGSERTITST EGSETTTVSA TGSETTVSTE GSGTTTVSIT
960 970 980 990 1000
GSETTKVSTT GSETTTTSTE GSEITTASIT GSETTTASTE GSETTTASTE
1010 1020 1030 1040 1050
GSETTSASTT GSETTTASTT SSETTMASIM GSETTMASTI GSETTKVSTA
1060 1070 1080 1090 1100
SSKMTTVFTE NSETTIASTT ASETTTVSTA GSETIPASTA GSETTTTTST
1110 1120 1130 1140 1150
EGSETTTAST EGSETTTAST ESSETTTATT IGSETTTAST EGSETTTTST
1160 1170 1180 1190 1200
EGSETTTAST EGSEITTVST TGSETTTAST EGSETTTAST EGSELTTVST
1210 1220 1230 1240 1250
TGSETITVSA EGSETTTVTT MGSETTTAST AGSETTTVST AGSETTTASI
1260 1270 1280 1290 1300
EGSETTTVSS TGSETTTVST TGTETTITST EGSETTTVTT AGSETTAVYT
1310 1320 1330 1340 1350
TGSETTTTST EGSETTTVST TGSETTTAST ADLETTTVST SGSGTTTAST
1360 1370 1380 1390 1400
AGSETTTVYI TGSKTTTAST EGSEATTVST TSSETTTAST TGSEMTTVFT
1410 1420 1430 1440 1450
TVSETTTVST IGSEATTSSA AGSEATTTST EGSETTTAST AGSETTTAST
1460 1470 1480 1490 1500
AGSETTTAST SGSETNTACT TGSETSTPSS AGSETNTAFI IGSESTIAST
1510 1520 1530 1540 1550
ASLEPTATSL TGSETTTVSI TASGATAAST TVSSTTFVLT KATDVSIQPI
1560 1570 1580 1590 1600
TNTPMSGTRT TGTRLTASSS VTMAPGMDFT ASAASHTVPG IVLNTSGLGT
1610 1620 1630 1640 1650
STMGASSTTS AHGVRTTTGS TREPTSSTFQ ETGPVSMGTN TVSMSHTPTN
1660 1670 1680 1690 1700
VIKPSGYLQP WAIILISLAA VVAAVGLSVG LSFCLRNLFF PLRYCGIYYP
1710 1720 1730 1740 1750
HGHSHSLGLD LNLGLGSGTF HSLGNALVHG GELEMGHGGT HGFGYGVGHG
1760 1770
LSHIHGDGYG VNHGGHYGHG GGH
Length:1,773
Mass (Da):173,478
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA25C9C6C4A5AC924
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57S → T in BAJ24154 (PubMed:20981447).Curated1
Sequence conflicti57S → T in BAJ33462 (PubMed:20981447).Curated1
Sequence conflicti57S → T in BAJ33463 (PubMed:20981447).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0653571712N → D1 PublicationCorresponds to variant dbSNP:rs4248153Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB560770 mRNA Translation: BAJ24154.1
AB600271 mRNA Translation: BAJ33462.1
AB600272 mRNA Translation: BAJ33463.1
AL669830 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59003.1

NCBI Reference Sequences

More...
RefSeqi
NP_001185744.1, NM_001198815.1
NP_001305413.1, NM_001318484.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.582967

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000561890; ENSP00000455906; ENSG00000261272

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100507679

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100507679

UCSC genome browser

More...
UCSCi
uc063mxr.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB560770 mRNA Translation: BAJ24154.1
AB600271 mRNA Translation: BAJ33462.1
AB600272 mRNA Translation: BAJ33463.1
AL669830 Genomic DNA No translation available.
CCDSiCCDS59003.1
RefSeqiNP_001185744.1, NM_001198815.1
NP_001305413.1, NM_001318484.1
UniGeneiHs.582967

3D structure databases

ProteinModelPortaliE2RYF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000455906

PTM databases

iPTMnetiE2RYF6
PhosphoSitePlusiE2RYF6

Polymorphism and mutation databases

BioMutaiMUC22

Proteomic databases

PaxDbiE2RYF6
PRIDEiE2RYF6
ProteomicsDBi15279

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561890; ENSP00000455906; ENSG00000261272
GeneIDi100507679
KEGGihsa:100507679
UCSCiuc063mxr.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100507679
DisGeNETi100507679
EuPathDBiHostDB:ENSG00000261272.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MUC22

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0164915
HIX0166030
HIX0166233
HIX0167061
HIX0167293
HIX0167600
HGNCiHGNC:39755 MUC22
MIMi613917 gene
neXtProtiNX_E2RYF6
OpenTargetsiENSG00000261272

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KGW0 Eukaryota
ENOG4110RWV LUCA
GeneTreeiENSGT00940000164570
InParanoidiE2RYF6
OMAiCTEETEN
OrthoDBi1320016at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100507679

Protein Ontology

More...
PROi
PR:E2RYF6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000261272 Expressed in 10 organ(s), highest expression level in esophagus mucosa

Family and domain databases

InterProiView protein in InterPro
IPR028199 Mucin_dom
PfamiView protein in Pfam
PF14654 Epiglycanin_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC22_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2RYF6
Secondary accession number(s): H3BQR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: October 3, 2012
Last modified: January 16, 2019
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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