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Protein

Mucin-22

Gene

MUC22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-22
Alternative name(s):
Panbronchiolitis-related mucin-like protein 1
Gene namesi
Name:MUC22
Synonyms:G4, PBMUCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000261272.1
HGNCiHGNC:39755 MUC22
MIMi613917 gene
neXtProtiNX_E2RYF6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1660ExtracellularSequence analysisAdd BLAST1634
Transmembranei1661 – 1681HelicalSequence analysisAdd BLAST21
Topological domaini1682 – 1773CytoplasmicSequence analysisAdd BLAST92

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100507679
OpenTargetsiENSG00000261272

Polymorphism and mutation databases

BioMutaiMUC22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000041047027 – 1773Mucin-22Add BLAST1747

Proteomic databases

PaxDbiE2RYF6
PRIDEiE2RYF6
ProteomicsDBi15279

PTM databases

iPTMnetiE2RYF6
PhosphoSitePlusiE2RYF6

Expressioni

Tissue specificityi

Expressed in lung by serous cells of the submucosal gland (at protein level). Detected in the placenta, lung and testis.1 Publication

Inductioni

Up-regulated by poly(I:C).1 Publication

Gene expression databases

BgeeiENSG00000261272

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000455906

Structurei

3D structure databases

ProteinModelPortaliE2RYF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 1514124 X 10 AA approximate repeatsAdd BLAST1362

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 1649Thr-richAdd BLAST1622

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KGW0 Eukaryota
ENOG4110RWV LUCA
GeneTreeiENSGT00730000111569
InParanoidiE2RYF6
OMAiCVLGTKV
OrthoDBiEOG091G16FI

Family and domain databases

InterProiView protein in InterPro
IPR028199 Mucin_dom
PfamiView protein in Pfam
PF14654 Epiglycanin_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E2RYF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGNISPAF WFLWLLLFGL LGPSSENTTA FTKGSDTTTA SITGSETTMA
60 70 80 90 100
STMASTSALT TGSKITTDST TGSETTSAST MASTAAFTTG SETNTASTTD
110 120 130 140 150
SGTTIASTRT FTTGSDTTTG STAGSETIVA STTVSGTTTT FTIASTTVPE
160 170 180 190 200
TTMASSTTST AGSEKTMASS IISETTMAST TGSETATVST TGSETTTTST
210 220 230 240 250
ASSEATKVST TGSETTTAST AGSETTTTST SMAGSEATTT STADSKVITA
260 270 280 290 300
SSMSSETTVA PAAGSNTTTA STTGSETTTI LIKASETTTA STAGSETTTP
310 320 330 340 350
SPTGSQTTIV SISGSEITTT STAGSENTTV SSAGSGTTTA SMAGSETTVS
360 370 380 390 400
TAGSETTTVS ITGTETTMVS AMGSETTTNS TTSSETTVTS TAGSETTTVS
410 420 430 440 450
TVGSETTTAY TADSETTAAS TTGSEMTTVF TAGSETITPS TAGSETTTVS
460 470 480 490 500
TAGSETTTVS TTGSETTTAS TAHSETTAAS TMGSETTKVS TAGSETTVST
510 520 530 540 550
AGSETTAAST EDSETNTAFT EDSKTTTAST TGFETTAAST TGSEPTMAST
560 570 580 590 600
MGSETTMAST IGPETTKVST ASSEVTTVFA AGSETIRAST VGSETTTVST
610 620 630 640 650
TGSETTTASI MGSETSTDST TGSETTTAST EGSETTTAST EGSEATTVST
660 670 680 690 700
TGSETTTVSI TDSETTTTCT EGSEMTAVST TVFETTTAST EGSEITIAST
710 720 730 740 750
SDSETTTAST EGSETTTVTT AGSETKTAYT TGSETTTASN TGLETTTVFT
760 770 780 790 800
IGSDTTTAST EGSETTAVSA TGSEMTTVST EGSENTTVST TGSETTTVST
810 820 830 840 850
TGLETTTTST EGSEMTTVST TGAETTTDST EGSGTTAAST AGSETTTVST
860 870 880 890 900
ADSENTTAST ADSETTSAST TGSETTTAST TSSETTTAST EGSETTTVST
910 920 930 940 950
TDSETTMVST TGSERTITST EGSETTTVSA TGSETTVSTE GSGTTTVSIT
960 970 980 990 1000
GSETTKVSTT GSETTTTSTE GSEITTASIT GSETTTASTE GSETTTASTE
1010 1020 1030 1040 1050
GSETTSASTT GSETTTASTT SSETTMASIM GSETTMASTI GSETTKVSTA
1060 1070 1080 1090 1100
SSKMTTVFTE NSETTIASTT ASETTTVSTA GSETIPASTA GSETTTTTST
1110 1120 1130 1140 1150
EGSETTTAST EGSETTTAST ESSETTTATT IGSETTTAST EGSETTTTST
1160 1170 1180 1190 1200
EGSETTTAST EGSEITTVST TGSETTTAST EGSETTTAST EGSELTTVST
1210 1220 1230 1240 1250
TGSETITVSA EGSETTTVTT MGSETTTAST AGSETTTVST AGSETTTASI
1260 1270 1280 1290 1300
EGSETTTVSS TGSETTTVST TGTETTITST EGSETTTVTT AGSETTAVYT
1310 1320 1330 1340 1350
TGSETTTTST EGSETTTVST TGSETTTAST ADLETTTVST SGSGTTTAST
1360 1370 1380 1390 1400
AGSETTTVYI TGSKTTTAST EGSEATTVST TSSETTTAST TGSEMTTVFT
1410 1420 1430 1440 1450
TVSETTTVST IGSEATTSSA AGSEATTTST EGSETTTAST AGSETTTAST
1460 1470 1480 1490 1500
AGSETTTAST SGSETNTACT TGSETSTPSS AGSETNTAFI IGSESTIAST
1510 1520 1530 1540 1550
ASLEPTATSL TGSETTTVSI TASGATAAST TVSSTTFVLT KATDVSIQPI
1560 1570 1580 1590 1600
TNTPMSGTRT TGTRLTASSS VTMAPGMDFT ASAASHTVPG IVLNTSGLGT
1610 1620 1630 1640 1650
STMGASSTTS AHGVRTTTGS TREPTSSTFQ ETGPVSMGTN TVSMSHTPTN
1660 1670 1680 1690 1700
VIKPSGYLQP WAIILISLAA VVAAVGLSVG LSFCLRNLFF PLRYCGIYYP
1710 1720 1730 1740 1750
HGHSHSLGLD LNLGLGSGTF HSLGNALVHG GELEMGHGGT HGFGYGVGHG
1760 1770
LSHIHGDGYG VNHGGHYGHG GGH
Length:1,773
Mass (Da):173,478
Last modified:October 3, 2012 - v2
Checksum:iA25C9C6C4A5AC924
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57S → T in BAJ24154 (PubMed:20981447).Curated1
Sequence conflicti57S → T in BAJ33462 (PubMed:20981447).Curated1
Sequence conflicti57S → T in BAJ33463 (PubMed:20981447).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0653571712N → D1 PublicationCorresponds to variant dbSNP:rs4248153Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB560770 mRNA Translation: BAJ24154.1
AB600271 mRNA Translation: BAJ33462.1
AB600272 mRNA Translation: BAJ33463.1
AL669830 Genomic DNA No translation available.
CCDSiCCDS59003.1
RefSeqiNP_001185744.1, NM_001198815.1
NP_001305413.1, NM_001318484.1
UniGeneiHs.582967

Genome annotation databases

EnsembliENST00000561890; ENSP00000455906; ENSG00000261272
GeneIDi100507679
KEGGihsa:100507679
UCSCiuc063mxr.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMUC22_HUMAN
AccessioniPrimary (citable) accession number: E2RYF6
Secondary accession number(s): H3BQR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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