Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CASP8 and FADD like apoptosis regulator

Gene

CFLAR

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-3371378 Regulation by c-FLIP
R-CFA-5213460 RIPK1-mediated regulated necrosis
R-CFA-5218900 CASP8 activity is inhibited
R-CFA-69416 Dimerization of procaspase-8

Names & Taxonomyi

Protein namesi
Submitted name:
CASP8 and FADD like apoptosis regulatorImported
Gene namesi
Name:CFLARImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 37

Organism-specific databases

VGNCiVGNC:39178 CFLAR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2RR61

Expressioni

Gene expression databases

BgeeiENSCAFG00000012130

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017879

Structurei

3D structure databases

ProteinModelPortaliE2RR61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78DEDInterPro annotationAdd BLAST73
Domaini97 – 175DEDInterPro annotationAdd BLAST79
Domaini270 – 365CASPASE_P20InterPro annotationAdd BLAST96

Sequence similaritiesi

Belongs to the peptidase C14A family.SAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00530000064199
InParanoidiE2RR61
OMAiYDWNSRV
OrthoDBiEOG091G05YD
TreeFamiTF352765

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PfamiView protein in Pfam
PF01335 DED, 2 hits
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SM00031 DED, 2 hits
SUPFAMiSSF47986 SSF47986, 2 hits
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50208 CASPASE_P20, 1 hit
PS50168 DED, 2 hits

Sequencei

Sequence statusi: Complete.

E2RR61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLYRMSAEV IHQVEEALDE DEKEMLLFLC RDVAADVAPL TVRDLLDILS
60 70 80 90 100
ERGELSAMGL AELLYRVRRF DLLKRIFKMD RRAVEAHLLR HPRLISDYRV
110 120 130 140 150
LMTEIGDDLD KSDVSSLIFL MRDHMGRNKV AKDKSFLDLV IELEKLNLIA
160 170 180 190 200
PDQLDLLEKC LKNIHRIDLK TKIQKYKQSA QGAGTNYTNA LQASFPNLSL
210 220 230 240 250
KDPSCNLRLQ NGRSKEQRLS VRQLDLQRES VKASVQESGP FLPRHIPEER
260 270 280 290 300
YRMQSKPLGI CLIIDCIGND TDFLRDTFTS LGYEVQYFLY LNVDSIIQIL
310 320 330 340 350
RQVARMPQHQ DYDSFVCVLV SRGGSQSVFG VDHTNSGFPL DQVRRMFMGD
360 370 380 390 400
ACPFLLGKPK LFFIQNYVVS EGQMDSSSFL EVDGPEVNNV ESKAKQPGPC
410 420 430 440 450
TIHREADFLW SLCKADVSLL EQSSGSPSLY LKCLSQKLGQ DRRRPLLELH
460 470 480
TELNSSVYDW NSRVSAKERY YVWLQHTLRK KLILSCK
Length:487
Mass (Da):55,946
Last modified:November 30, 2010 - v1
Checksum:i6BDC64EFE4FE1DB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03018016 Genomic DNA No translation available.
AAEX03018017 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000019278; ENSCAFP00000017879; ENSCAFG00000012130

Similar proteinsi

Entry informationi

Entry nameiE2RR61_CANLF
AccessioniPrimary (citable) accession number: E2RR61
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health