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Protein
Submitted name:

Membrane metalloendopeptidase

Gene

MME

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-CFA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Membrane metalloendopeptidaseImported
Gene namesi
Name:MMEImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:43271 MME

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 51HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiE2RQ25
PRIDEiE2RQ25

Expressioni

Gene expression databases

BgeeiENSCAFG00000008711 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012835

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 484Peptidase_M13_NInterPro annotationAdd BLAST405
Domaini544 – 750Peptidase_M13InterPro annotationAdd BLAST207

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili270 – 290Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624 Eukaryota
COG3590 LUCA
GeneTreeiENSGT00760000119162
InParanoidiE2RQ25
OMAiTATWRRC
OrthoDBiEOG091G025Y
TreeFamiTF315192

Family and domain databases

CDDicd08662 M13, 1 hit
Gene3Di3.40.390.10, 3 hits
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR029727 MME/CD10/NEP
IPR000718 Peptidase_M13
IPR018497 Peptidase_M13_C
IPR008753 Peptidase_M13_N
PANTHERiPTHR11733 PTHR11733, 1 hit
PTHR11733:SF114 PTHR11733:SF114, 1 hit
PfamiView protein in Pfam
PF01431 Peptidase_M13, 1 hit
PF05649 Peptidase_M13_N, 1 hit
PRINTSiPR00786 NEPRILYSIN

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

E2RQ25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRSESQMDI TDISTPRPKK QRWTSLEISL SVLVLLLTII AVTMIALYAT
60 70 80 90 100
YDEKLCKKQS CFRGLSAARL IQNMDATAEP CTDFFKYACG GWLKRNVIPE
110 120 130 140 150
TSSRYSNFDI LRDELEVVLK DVLQEPKTED IVAVQKAKTL YRSCINESAI
160 170 180 190 200
DSRGGQPLLS LLPDIYDWPV ATDNWEQTYG TSWTAEKSIA QLNSKYGKKV
210 220 230 240 250
ILNFFVGTDD KNSVNHIIHI DQPRLGLPSR DYYVCTGIYE EACTAYKDFM
260 270 280 290 300
ISVARLIRKE KGLLIDENQL SLEMNRVMEL EKEIASATTK PEDRNDPMLL
310 320 330 340 350
YNKMTLAQIQ NNFTLEIDGK PFSWSNFTNE IMSTVNINIP NEEEVVVYAP
360 370 380 390 400
EYLTKLKLIL TKYSSRDLQN LMSWRFIMDL VSSLSRNYKE SRNAFRKALY
410 420 430 440 450
GTTSETATWR RCANYVNGNM ENAVGRLYVE AAFAGESKHV VEDLITQIRA
460 470 480 490 500
VFIQTLDDLT WMDAETKKKA EEKALAIKER IGYPDDIISN DSKLDNEYLE
510 520 530 540 550
LNYREDEYFE NIIQNLKFSQ NKQLKKLREK VDKDEWISGA AVVNAFYSSG
560 570 580 590 600
RNQIVFPAGI LQPPFFSAQQ SNSLNYGGIG MVIGHEITHG FDDNGRNFNK
610 620 630 640 650
DGDLVDWWTQ QSANNFKDQS QCMVYQYGNF SWDLAGGQHL NGINTLGENI
660 670 680 690 700
ADNGGIGQAY RAYQNYVKKN GEEKLLPGLD LNHKQLFFLN FAQVWCGTYR
710 720 730 740 750
PEYAVNSIKT DVHSPGNFRI IGTLQNSPEF SEAFHCRKNS YMNPEKKCRV

W
Length:751
Mass (Da):85,921
Last modified:November 30, 2010 - v1
Checksum:i05D13F8C5FB90B4F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5C3N2F5C3N2_CANLF
Membrane metalloendopeptidase
MME
749Annotation score:
F6M3K2F6M3K2_CANLF
Membrane metalloendopeptidase
MME
410Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013696 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000013874; ENSCAFP00000012835; ENSCAFG00000008711

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013696 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012835

Proteomic databases

PaxDbiE2RQ25
PRIDEiE2RQ25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000013874; ENSCAFP00000012835; ENSCAFG00000008711

Organism-specific databases

VGNCiVGNC:43271 MME

Phylogenomic databases

eggNOGiKOG3624 Eukaryota
COG3590 LUCA
GeneTreeiENSGT00760000119162
InParanoidiE2RQ25
OMAiTATWRRC
OrthoDBiEOG091G025Y
TreeFamiTF315192

Enzyme and pathway databases

ReactomeiR-CFA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-CFA-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSCAFG00000008711 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd08662 M13, 1 hit
Gene3Di3.40.390.10, 3 hits
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR029727 MME/CD10/NEP
IPR000718 Peptidase_M13
IPR018497 Peptidase_M13_C
IPR008753 Peptidase_M13_N
PANTHERiPTHR11733 PTHR11733, 1 hit
PTHR11733:SF114 PTHR11733:SF114, 1 hit
PfamiView protein in Pfam
PF01431 Peptidase_M13, 1 hit
PF05649 Peptidase_M13_N, 1 hit
PRINTSiPR00786 NEPRILYSIN
ProtoNetiSearch...

Entry informationi

Entry nameiE2RQ25_CANLF
AccessioniPrimary (citable) accession number: E2RQ25
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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