Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Piwi like RNA-mediated gene silencing 2

Gene

PIWIL2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRNA-mediated gene silencingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Piwi like RNA-mediated gene silencing 2Imported
Gene namesi
Name:PIWIL2Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:44593 PIWIL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2RP57

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013899

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini388 – 501PAZInterPro annotationAdd BLAST114
Domaini667 – 958PiwiInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the argonaute family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1042 Eukaryota
ENOG410XNRH LUCA
GeneTreeiENSGT00760000119148
InParanoidiE2RP57
OMAiNKEHFQD
OrthoDBiEOG091G020J
TreeFamiTF354206

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR014811 ArgoL1
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR003165 Piwi
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF08699 ArgoL1, 1 hit
PF02170 PAZ, 1 hit
PF02171 Piwi, 1 hit
SMARTiView protein in SMART
SM01163 DUF1785, 1 hit
SM00949 PAZ, 1 hit
SM00950 Piwi, 1 hit
SUPFAMiSSF101690 SSF101690, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821 PAZ, 1 hit
PS50822 PIWI, 1 hit

Sequencei

Sequence statusi: Complete.

E2RP57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPVRPPFRG SSVHPSQCVR MPGPWPQAPK PLDSALGRAG PAGRGHVFGK
60 70 80 90 100
PGEPSKQSGP AQRESVGFVS MFRGLGLETV SRAPLKREMP PSGRGILGRG
110 120 130 140 150
LSASMVRKDK EEPHSTFADP SVLAAGDSKM AEACVGWNRM LGRGNSNTSL
160 170 180 190 200
LSLGRAAGGL GRGVHKAPGA ISLTCRDPSQ LSSPPPLPPS SPHSLDHSLL
210 220 230 240 250
GAVEHKEHKE KEVFVKQGSK GTPQSLGLNL IKIQCHNEAV YQYHVTFSPN
260 270 280 290 300
VECKSMRFGM LKDHQAVTGN VTAFDGSILY LPIKLQQVLE LKSQRKTDGA
310 320 330 340 350
DINIKIQLTK TLEPCSDLCI PFYNVVFRRV MKLLDMKLVG RNFYDPTSAM
360 370 380 390 400
VLQQHRLQIW PGYAASIRRT DGGLFLLADV SHKVIRNDSV LDVMHAIYQQ
410 420 430 440 450
NKENFQDECT KLLVGNIVIT RYNNRTYRID DVDWNKTPKD SFTMSDGKEI
460 470 480 490 500
TFLEYYSKNY GITIKEEDQP LLIHRPSERQ NQGMLLKGEI LLLPELSFMT
510 520 530 540 550
GIPEKMKKDF RAMKDLTQQI NLSPKQHHNA LECLLQRISK NETASNELAR
560 570 580 590 600
WGLYLQKDVH KIEGRVLPME RINLRNTSFI TSQELNWIKE VTRDLSILTV
610 620 630 640 650
PMHFWALFYP KRAMDQAREL VNMLEKIAGP IGMRMSPPAW VELKDDRIET
660 670 680 690 700
YVRTIQSMLG VEGKIQMVVC IIMGTRDDLY GAIKKLCCVQ APVPSQVINV
710 720 730 740 750
RTIGQPTRLR SVAQKILLQI NCKLGGELWG VDIPLKQLMV IGMDVYHDPS
760 770 780 790 800
RGMRSVVGFV ASINLTLTKW YSRVVFQMPH QEIVDSLKLC LVGSLKKFYE
810 820 830 840 850
VNHCLPEKIV VYRDGVSDGQ LKTVANYEIP QLQKCFEAFE NYQPKMVVFV
860 870 880 890 900
VQKKISTNLY LAATEHFVTP SPGTVVDHTI TSCEWVDFYL LAHHVRQGCG
910 920 930 940 950
IPTHYVCVLN TANLSPDHMQ RLTFKLCHMY WNWPGTIRVP APCKYAHKLA
960 970
FLSGQILHHE PAIQLCENLF FL
Length:972
Mass (Da):109,414
Last modified:October 31, 2012 - v2
Checksum:i705C3671E89CCA03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03014377 Genomic DNA No translation available.
AAEX03014378 Genomic DNA No translation available.
RefSeqiXP_543251.2, XM_543251.3

Genome annotation databases

EnsembliENSCAFT00000015020; ENSCAFP00000013899; ENSCAFG00000009444
GeneIDi486125

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03014377 Genomic DNA No translation available.
AAEX03014378 Genomic DNA No translation available.
RefSeqiXP_543251.2, XM_543251.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013899

Proteomic databases

PaxDbiE2RP57

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015020; ENSCAFP00000013899; ENSCAFG00000009444
GeneIDi486125

Organism-specific databases

CTDi55124
VGNCiVGNC:44593 PIWIL2

Phylogenomic databases

eggNOGiKOG1042 Eukaryota
ENOG410XNRH LUCA
GeneTreeiENSGT00760000119148
InParanoidiE2RP57
OMAiNKEHFQD
OrthoDBiEOG091G020J
TreeFamiTF354206

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR014811 ArgoL1
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR003165 Piwi
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF08699 ArgoL1, 1 hit
PF02170 PAZ, 1 hit
PF02171 Piwi, 1 hit
SMARTiView protein in SMART
SM01163 DUF1785, 1 hit
SM00949 PAZ, 1 hit
SM00950 Piwi, 1 hit
SUPFAMiSSF101690 SSF101690, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821 PAZ, 1 hit
PS50822 PIWI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2RP57_CANLF
AccessioniPrimary (citable) accession number: E2RP57
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again