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Protein
Submitted name:

DExD/H-box helicase 58

Gene

DDX58

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi814ZincPROSITE-ProRule annotation1
Metal bindingi817ZincPROSITE-ProRule annotation1
Metal bindingi868ZincPROSITE-ProRule annotation1
Metal bindingi873ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-CFA-1169408 ISG15 antiviral mechanism
R-CFA-5689880 Ub-specific processing proteases
R-CFA-936440 Negative regulators of DDX58/IFIH1 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
DExD/H-box helicase 58Imported
Gene namesi
Name:DDX58Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:39867 DDX58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2RMV6

Expressioni

Gene expression databases

BgeeiENSCAFG00000001807 Expressed in 3 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000002634

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 429Helicase ATP-bindingInterPro annotationAdd BLAST180
Domaini614 – 780Helicase C-terminalInterPro annotationAdd BLAST167
Domaini798 – 929RLR CTRInterPro annotationAdd BLAST132

Phylogenomic databases

eggNOGiKOG0354 Eukaryota
COG1111 LUCA
GeneTreeiENSGT00510000046789
InParanoidiE2RMV6
OMAiESWDFQK
OrthoDBiEOG091G01PQ
TreeFamiTF330258

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di2.170.150.30, 1 hit
InterProiView protein in InterPro
IPR031964 CARD_dom
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038557 RLR_C_sf
IPR021673 RLR_CTR
PfamiView protein in Pfam
PF16739 CARD_2, 2 hits
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF11648 RIG-I_C-RD, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51789 RLR_CTR, 1 hit

Sequencei

Sequence statusi: Complete.

E2RMV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAEERRNLH AFRDYVIKTL DPAYILSYMA PWFKDDEVQY IQAEKNNKGT
60 70 80 90 100
MEAASLFLKC LLELQEEGWF RGFLDALGHA GYSGLYEAIE SWNFQKIESL
110 120 130 140 150
EEYRLLLKRL QPEFKTTVNP NDILPKISEC LISQECEEII QICSNKGLMA
160 170 180 190 200
GAEKMVECLL RSDKENWPKT LKLALETEES KFSQLWIVDK SHTDVELKVL
210 220 230 240 250
EDEEIETSEV QIFYKEEPEC QNLSQDPCPP SEVASTCTPL KPRNYQLELA
260 270 280 290 300
LPAKEGKNTI ICAPTGCGKT FVALLICEHH LKKFPQGQKG KIVFFAIQIP
310 320 330 340 350
VYEQQNSVFS KYFERLGYKV AGISGATSEN ISVEQIVENN DIIVLTPQIL
360 370 380 390 400
VNCLRNGTIP SLSVFTLMIF DECHNTSKHH PYNMIMFNYL DQKLGGSSDP
410 420 430 440 450
LPQVVGLTAS VGIGDAKNTM EAMEYICKLC ASLDTSVIAT VKDNLEELEE
460 470 480 490 500
IVYKPQKFFR KVESRTTDRF KCIISQLMRE TESLAKNIFD ELGTITLENV
510 520 530 540 550
SQIQNRNFGT QKYEQWIVSV QKACMVFQLP NKDEESRICK ALFLYTSHLR
560 570 580 590 600
KYNDALIINE HARMKDALDY LKDFFTDVRA AGFDEIEQHL TYRFEEKLQE
610 620 630 640 650
LESISMDLSN ENPKLKDLSF ILQEEYHLNP ESRTILFVKT RALVDALKKW
660 670 680 690 700
IEENSELSFL KPGILTGRGK TNHNTGMTLP AQKCALDAFR TDGDKKILIA
710 720 730 740 750
TSVADEGIDI AQCNLVILYE YVGNVIRMIQ TRGRGRARGS KCFLLTSNAD
760 770 780 790 800
VIKKEKLNIY KEKIMNDSIL SLQMWNEAVF KEKVLQIQIQ EKNIRDSQEK
810 820 830 840 850
VELVPDKENK KLLCRKCKAF ACYTADIRVV EECHYTVVGD AFTKCFVSKL
860 870 880 890 900
HPKPKSFGHF EKRAKIFCAR RNCGHDWGIH VKYKTFEIPV IKIESFVVED
910 920
IATGAQKLYA KWKDFPFEKI PFGSPEIPE
Length:929
Mass (Da):106,510
Last modified:October 31, 2012 - v2
Checksum:iAEDCA167E28F9FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03007933 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000002841; ENSCAFP00000002634; ENSCAFG00000001807

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03007933 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000002634

Proteomic databases

PaxDbiE2RMV6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000002841; ENSCAFP00000002634; ENSCAFG00000001807

Organism-specific databases

VGNCiVGNC:39867 DDX58

Phylogenomic databases

eggNOGiKOG0354 Eukaryota
COG1111 LUCA
GeneTreeiENSGT00510000046789
InParanoidiE2RMV6
OMAiESWDFQK
OrthoDBiEOG091G01PQ
TreeFamiTF330258

Enzyme and pathway databases

ReactomeiR-CFA-1169408 ISG15 antiviral mechanism
R-CFA-5689880 Ub-specific processing proteases
R-CFA-936440 Negative regulators of DDX58/IFIH1 signaling

Gene expression databases

BgeeiENSCAFG00000001807 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di2.170.150.30, 1 hit
InterProiView protein in InterPro
IPR031964 CARD_dom
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038557 RLR_C_sf
IPR021673 RLR_CTR
PfamiView protein in Pfam
PF16739 CARD_2, 2 hits
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF11648 RIG-I_C-RD, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51789 RLR_CTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2RMV6_CANLF
AccessioniPrimary (citable) accession number: E2RMV6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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