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Entry version 69 (16 Oct 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Multiple EGF like domains 8

Gene

MEGF8

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multiple EGF like domains 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEGF8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:43148 MEGF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2590 – 2612HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500316367228 – 2787Sequence analysisAdd BLAST2760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 57PROSITE-ProRule annotation
Disulfide bondi173 ↔ 183PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi1181 ↔ 1190PROSITE-ProRule annotation
Disulfide bondi1193 ↔ 1207PROSITE-ProRule annotation
Disulfide bondi1232 ↔ 1241PROSITE-ProRule annotation
Disulfide bondi1244 ↔ 1258PROSITE-ProRule annotation
Disulfide bondi1434 ↔ 1443PROSITE-ProRule annotation
Disulfide bondi2215 ↔ 2224PROSITE-ProRule annotation
Disulfide bondi2227 ↔ 2241PROSITE-ProRule annotation
Disulfide bondi2369 ↔ 2383PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E2RM39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000004824 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000007208

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E2RM39

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 139CUBInterPro annotationAdd BLAST110
Domaini169 – 202EGF-likeInterPro annotationAdd BLAST34
Domaini1073 – 1114EGF-likeInterPro annotationAdd BLAST42
Domaini1162 – 1209Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1210 – 1260Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1262 – 1404CUBInterPro annotationAdd BLAST143
Domaini1402 – 1444EGF-likeInterPro annotationAdd BLAST43
Domaini2120 – 2158EGF-likeInterPro annotationAdd BLAST39
Domaini2195 – 2243Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini2322 – 2385Laminin EGF-likeInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2464 – 2507DisorderedSequence analysisAdd BLAST44
Regioni2763 – 2787DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2614 – 2634Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2466 – 2485Pro-richSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationSAAS annotation, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1388 Eukaryota
ENOG410YF0N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160262

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E2RM39

Identification of Orthologs from Complete Genome Data

More...
OMAi
CREWMDQ

TreeFam database of animal gene trees

More...
TreeFami
TF321873

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 4 hits
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR015915 Kelch-typ_b-propeller
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF07645 EGF_CA, 2 hits
PF00053 Laminin_EGF, 4 hits
PF01437 PSI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 1 hit
SM00181 EGF, 13 hits
SM00179 EGF_CA, 2 hits
SM00180 EGF_Lam, 4 hits
SM00423 PSI, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 2 hits
SSF49854 SSF49854, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01180 CUB, 2 hits
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E2RM39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGSALAVA LALPLALLGP LFPGARAGDC KGQRQVLREA PGFVTDGAGN
60 70 80 90 100
YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYG DSPRGPLLAS
110 120 130 140 150
LSGSTRPPPI EASSGKMLLH LFSDANYNLL GFNASYRFTL CPGGCSGHGQ
160 170 180 190 200
CQAPGVCTCE PGWGGPDCSL QECPAYCGSH GTCASPLGPC RCEPGFLGRA
210 220 230 240 250
CDLHLWENQG AGWWHNVSAG DPAFSARIGA AGAFLSPPGL LAVFGGQDLN
260 270 280 290 300
SALGDLVLYN FSANTWERWD LSPAPAARHS HVAVAWAGSL VLMGGELANG
310 320 330 340 350
SLTSDVWAFS PLDGGHWELL APPVLSSSGP PGLAGHAAAL VDDIWLYVSG
360 370 380 390 400
GRTQHDLFSS GLFRFRLDST SGGYWEQVVP AGGRPPAATG HSMVFHAPSR
410 420 430 440 450
TLLVHGGHRP STARFSVRVN STELFHVDRR VWTTLKGRDG LQGPRERAFH
460 470 480 490 500
TASVLGNYMV VYGGNVHTHY QEEKCYEDGL FFYHLGCHQW VSGAELAPPG
510 520 530 540 550
TPEGRAAPPS GRYSHVAAVL GGSVLLVAGG YSGRPRGDLM AYKVPPFVFQ
560 570 580 590 600
APAPDYHLDY CSMYTDHSVC SRDPECSWCQ GACQAAPPPG TPSGECPAAS
610 620 630 640 650
CLGLGRLLGD CQACLAFSSP TAPPRGPGAL GWCVHNESCL PRPEQARCRG
660 670 680 690 700
EQISGTVGWW GPAPVFVTSL EACVTQSFLP GLHLLTFQQP PNASQPDKVL
710 720 730 740 750
IVRSTTITLT PSPETDVSLV YRGFIHPLLP GGPGGPGAED VAVWARAQRL
760 770 780 790 800
HVLARMARGP DTENMEEVGR WVAQQEKETR RLQRPGSARL FPLPGRGHKY
810 820 830 840 850
AVEIRGQLNG SAGPGHSELT LLWDRTGVPG GSEISFFFLE PYRSSACSSY
860 870 880 890 900
SSCLGCLADQ GCGWCLTSAT CHLRQSGAHC GDDGAGGSLL VLVPALCPLC
910 920 930 940 950
EEHRDCHACT QDPFCEWHQS TNRKGDAACS RRGRSRGALK SPEECPPLCS
960 970 980 990 1000
QRLTCDDCLA NSSQCAWCQS THTCFLFAAY LARYPHGGCR GWDDSVHSEP
1010 1020 1030 1040 1050
RCRSCDRFLT CHECLQSHEC GWCGNEDNPT LGRCLQGDFS GPLGGGNCSL
1060 1070 1080 1090 1100
WVGEGLGLSV ALPARWAYAR CPDVDECRLG LARCHLRATC LNTPLSYECH
1110 1120 1130 1140 1150
CQRGYQGDGI TYCNRTCLED CGHGVCSGPP DFTCVCDLGW TSDLPPPTPA
1160 1170 1180 1190 1200
PGPPAPRCSR DCGCNFHSHC RKRGPGFCDE CQDWTWGEHC ERCRPGSFGN
1210 1220 1230 1240 1250
ATGSGGCRPC QCNGHGDPRR GHCDNLSGLC FCQDHTEGAH CQFCSPGYYG
1260 1270 1280 1290 1300
DPRAGGSCFR ECGGRALLTN VSSVALGSRR VGGLLPPGGG AARAGPGLSY
1310 1320 1330 1340 1350
CVWVVSATEV LQPCAPGTLC PPLTLTFSPD SSTPCTLSYV LAFDGFPRFL
1360 1370 1380 1390 1400
DTGVVQSDRS LIAAFCGQRR DRPLTVQALS GLLVLHWEAN GSSSWGFNAS
1410 1420 1430 1440 1450
VGSARCGSGG PGSCPVPQEC IPQDGATGAG LCRCPQGWAG PHCRMALCPE
1460 1470 1480 1490 1500
NCNAHSGAGT CNQSLGVCIC AEGFGGPDCA TKLDGGQLVW ETLMDSRLSA
1510 1520 1530 1540 1550
DTASRFLHRL GHTMVEGPDA TLWMFGGLGL PQGLLGNLYR YSVSERRWTQ
1560 1570 1580 1590 1600
MLAGAEDGGP GPSPRSFHAA AYVSSGRGAM YLLGGLTAGG VARDFWILNL
1610 1620 1630 1640 1650
TTLQWRQEKV PQTVELPAVA GHTLTSRRGL SLLLVGGYSP ESGFNQQLFE
1660 1670 1680 1690 1700
YQLVTGTWVG AQSGTPPTGL YGHSAVYHEA TDSLYVFGGF RFHVELAAPS
1710 1720 1730 1740 1750
PELYSLHCPD RTWSLLAPSQ GAKPRPRLFH ASALLGDTMV VLGGRSDPDE
1760 1770 1780 1790 1800
FSSDVLLYQV NCNAWLLPDL TRPASVGPPM EESVAHAVAA VGGRLYLSGG
1810 1820 1830 1840 1850
FGGVALGRLL ALTLPPDPCR LLPSPEACNQ SGACTWCHGA CLSGDQAHRL
1860 1870 1880 1890 1900
GCGGPPCSPM PRSPEECRRL RTCSECLARH PRTLQPGDGE ASAPRCKWCT
1910 1920 1930 1940 1950
NCPEGACIGR NGSCTSENDC RINQREVFWA GNCSEAVCGA ADCEQCTREG
1960 1970 1980 1990 2000
KCMWTRQFKR TGETRRILSV QPTYDWTCFS HSLLNVSPMP VESSPPLPCP
2010 2020 2030 2040 2050
TPCHLLPNCT SCLDSKGADG GWQHCVWSSS LQQCLSPSYL PLRCMAGGCG
2060 2070 2080 2090 2100
RLLRGPESCS LGCAQATQCA LCLRRPHCGW CAWGGQDGGG HCLEGGLSGP
2110 2120 2130 2140 2150
RDGLTCGRPE ASWAFLSCPP EDECANGHHD CNETQNCHDR PHGYECSCKA
2160 2170 2180 2190 2200
GYTMDNVTGL CRPVCAQGCV NGSCVEPDHC RCHFGFVGRN CSTECRCNRH
2210 2220 2230 2240 2250
SECAGVGARD HCLLCRNHTK GSHCEQCLPL FVGSAVGGGT CRPCHAFCRG
2260 2270 2280 2290 2300
NSHVCVSRKE LEMARKEPEK YPLDPEEIEN WVTEGPSEDE AVCVNCQNNS
2310 2320 2330 2340 2350
YGDKCESCLH GYFLLDGKCT KCQCNGHADT CNEQDGTGCP CQNNTETGTC
2360 2370 2380 2390 2400
QGSSPSDRRD CYKYQCAKCR ESFHGSPLGG QQCYRLISVE QECCLDPTSQ
2410 2420 2430 2440 2450
TNCFHEPKRR ALGPGRTVLF GVQPKFTNVD IRLTLDVTFG AVDLYVSTSY
2460 2470 2480 2490 2500
DTFVVRVAPD TGVHTVHIQP PPPPPPPPPP ADGGPRVAGD PGGPGAGNGP
2510 2520 2530 2540 2550
GTPAEPRVRE VWPRGLITYV TVTEPSAVLV VRGVRDRLVI TYPHEHHALK
2560 2570 2580 2590 2600
SSRFYLLLLG VGDPSGPGAN GSADSQGLLF FRQDQAHIDL FVFFSVFFSC
2610 2620 2630 2640 2650
FFLFLSLCVL LWKAKQALDQ RQEQRRHLQE MTKMASRPFA KVTVCFPPDP
2660 2670 2680 2690 2700
AAPAPAWKPA GLPPPTFRRS EPFLAPLLLT GAGGPWGPVG GGCCPPAIPA
2710 2720 2730 2740 2750
TTAGLRAGPI TLEPTEDGMA GVATLLLQLP GGPQAPNGAC LGSALVTLRH
2760 2770 2780
RLHEYCGGGG GAGGSGHGAG AGRKGLLSQD NLTSMSL
Length:2,787
Mass (Da):296,935
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE20B08BD65357AA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03000913 Genomic DNA No translation available.
AAEX03000914 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000007776; ENSCAFP00000007208; ENSCAFG00000004824

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000913 Genomic DNA No translation available.
AAEX03000914 Genomic DNA No translation available.

3D structure databases

SMRiE2RM39
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000007208

Proteomic databases

PaxDbiE2RM39

Genome annotation databases

EnsembliENSCAFT00000007776; ENSCAFP00000007208; ENSCAFG00000004824

Organism-specific databases

VGNCiVGNC:43148 MEGF8

Phylogenomic databases

eggNOGiKOG1388 Eukaryota
ENOG410YF0N LUCA
GeneTreeiENSGT00940000160262
InParanoidiE2RM39
OMAiCREWMDQ
TreeFamiTF321873

Gene expression databases

BgeeiENSCAFG00000004824 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.120.10.80, 4 hits
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR015915 Kelch-typ_b-propeller
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF07645 EGF_CA, 2 hits
PF00053 Laminin_EGF, 4 hits
PF01437 PSI, 1 hit
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00181 EGF, 13 hits
SM00179 EGF_CA, 2 hits
SM00180 EGF_Lam, 4 hits
SM00423 PSI, 9 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF49854 SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01180 CUB, 2 hits
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2RM39_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2RM39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: October 16, 2019
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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