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Protein
Submitted name:

BRCA1 interacting protein C-terminal helicase 1

Gene

BRIP1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-5685938 HDR through Single Strand Annealing (SSA)
R-CFA-5685942 HDR through Homologous Recombination (HRR)
R-CFA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-CFA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-CFA-5693579 Homologous DNA Pairing and Strand Exchange
R-CFA-5693607 Processing of DNA double-strand break ends
R-CFA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-CFA-6804756 Regulation of TP53 Activity through Phosphorylation
R-CFA-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Submitted name:
BRCA1 interacting protein C-terminal helicase 1Imported
Gene namesi
Name:BRIP1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:38530 BRIP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiE2RHN5

Expressioni

Gene expression databases

BgeeiENSCAFG00000017737 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026175

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 442Helicase ATP-bindingInterPro annotationAdd BLAST432

Phylogenomic databases

eggNOGiKOG1132 Eukaryota
COG1199 LUCA
GeneTreeiENSGT00530000063199
InParanoidiE2RHN5
OMAiTNNDMNQ
OrthoDBiEOG091G00LK
TreeFamiTF329449

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF13307 Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 6 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

E2RHN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLWSEYTI GGVKITFPYK AYPSQLAMMN SIVRGLNSKQ HCLLESPTGS
60 70 80 90 100
GKSLALLCST LAWQQSVSGK LVDESLSKTE VSSSCCCACH SKNFTNIDLN
110 120 130 140 150
QGTSHHFNSP STPPSERYDT SSTCQEDSPE KTTLAAKLSA KKQASIKRDE
160 170 180 190 200
NDDFQVEKKR IRPLETTQQI RKRHCFEKKV HHVDAKVASG KTTKLNSPLE
210 220 230 240 250
KINSFSPQNP PGHCSRCCCS TKQGSNQDSS NTTKKDHGGK SKIPKIYFGT
260 270 280 290 300
RTHKQIAQIT RELRRTAYSG VPMTILSSRD HTCVHPEVVG NFNRNEKCME
310 320 330 340 350
LLDGKNGKSC YFYHGVHKIS NQHTLQTLQG MCKAWDIEEL VSLGKKLKAC
360 370 380 390 400
PYYTARELIE DAHIIFCPYN YLLDAQIRES MDINLKEQVV ILDEAHNIED
410 420 430 440 450
CARESASYSV TEVQLRFARD ELDSMVNNNI RKKNHEPLRA VCYSLINWLE
460 470 480 490 500
ANSEHLVERD YESSCKIWSG SEMVLNLHKM GITTATFPIL QGHFSAVLQK
510 520 530 540 550
EEKVLPIHGK EETREVPIIS ASTQIMLKGL FMVFDYLFRQ NSRFADDYKV
560 570 580 590 600
AIQQTYSWIN QTDTSDKNGF FAPAKNKKHL RQKTAVHVLN FWCLNPAVAF
610 620 630 640 650
SDINGKVLTI VLTSGTLSPM KSFSSELGVT FTIQLEANHV INNSQVWVGT
660 670 680 690 700
IGSGPKGRNL CATFQHTETF EFQDEVGALL LSVCQTVNQG ILCFLPSYKL
710 720 730 740 750
LEKLKERWLY TGLWHNLELV KTVIVEPQGG EKTDFNELLQ VYYDAIKYKG
760 770 780 790 800
EKDGALLVAV CRGKVSEGLD FSDDNARAVI TIGIPFPNVK DLQVELKRQY
810 820 830 840 850
NDQHSKLRGL LPGRQWYEIQ AYRALNQALG RCIRHKNDWG ALILVDDRFR
860 870 880 890 900
SNPSRYISGL SKWIRQQIQH HSTFESALES LSDFSRKHQK VINVSKEDRK
910 920 930 940 950
FTQDSESILE VTCLKDNTLT YLEAASPLIP ENPRKGEAKI RVQEQQCLTI
960 970 980 990 1000
TESPPLPRGI ISKKEKDDPV LSEEFAQAVK AEKNVISRST SPIFNKQTKP
1010 1020 1030 1040 1050
VSWSNFNSLE RYFTGEILTA GPKFRSPEDC ASSISTLETE EGYKTVLPLT
1060 1070 1080 1090 1100
DKCESSSPML NASCSQSEVI SSVKIDSTLL KRNCSKQLFC CEEAVDPDIE
1110 1120 1130 1140 1150
LSLLGEEAKS STSHRASETE AEDESIYFSP ELYDPADTNE EKNELVESDR
1160 1170 1180 1190 1200
DNRFVDHSNC ILVEDLFEIR TIKGVDSVQE MKAEDCTVTT LNRLMHIKES
1210 1220 1230 1240
KIDNIDSNMK THINELELGK TCETDIKNFN QLPSKNKGVF LVLD
Length:1,244
Mass (Da):140,432
Last modified:November 30, 2010 - v1
Checksum:iF19F4D27FF2F012E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9NVZ8J9NVZ8_CANLF
BRCA1 interacting protein C-termina...
BRIP1
1,214Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006594 Genomic DNA No translation available.
AAEX03006595 Genomic DNA No translation available.
AAEX03006596 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000028135; ENSCAFP00000026175; ENSCAFG00000017737

Similar proteinsi

Entry informationi

Entry nameiE2RHN5_CANLF
AccessioniPrimary (citable) accession number: E2RHN5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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