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Entry version 51 (16 Oct 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Cullin associated and neddylation dissociated 2 (putative)

Gene

CAND2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cullin associated and neddylation dissociated 2 (putative)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAND2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:54586 CAND2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
E2RFC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000004904 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000007344

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
E2RFC3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1192 – 1352TIP120InterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 137DisorderedSequence analysisAdd BLAST137
Regioni462 – 493DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi465 – 491AcidicSequence analysisAdd BLAST27

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1824 Eukaryota
ENOG410XPK4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017740

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E2RFC3

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMAALIS

TreeFam database of animal gene trees

More...
TreeFami
TF300355

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120

The PANTHER Classification System

More...
PANTHERi
PTHR12696 PTHR12696, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08623 TIP120, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E2RFC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METLRLGDAK PLGPGYVTGE RGEAGFEPET LRSRARATQP GSGPQESQGG
60 70 80 90 100
GCRGEAVTSP SPGVCKPAPP ASVGRGRGRA RGEPAKPVAG PVRPPRPPRP
110 120 130 140 150
RRERGATPAG RGLLFLSGER SPRGEAGEGA PAQPYSLPPA APRRAATMST
160 170 180 190 200
AAFHISSLLE KMTSSDKDFR FMATSDLMSE LQKDSIQLDE DSERKVVKML
210 220 230 240 250
LRLLEDKNGE VQNLAVKCLG PLVGKVKEYQ VETIVDALCA NMRSDKEQLR
260 270 280 290 300
DIAGIGLKTV LSELPPAATG SGLATNVCRK ITGQLTSAIA QQEDVAVQLE
310 320 330 340 350
ALDILSDMLS RLGAPLGAFH ASLLHCLLPQ LSSPRLAVRK RAVGALGHLA
360 370 380 390 400
AACSTDLFVE LADHLLDRLP GPRAPTSPAA VRTLIQCLGS VGRQAGHRLG
410 420 430 440 450
AHLDRLVPLV EEFCNLDDDE LRESCLQAFE AFLRKCPKEM GPHVPNVTSL
460 470 480 490 500
CLQYIKHDPN YNYDSDGDEE QMETEDNEFS EQESEDEYSD DDDMSWKVRR
510 520 530 540 550
AAAKCIAALI GSRPDLLPDF HCTLAPALIR RFKEREENVK ADVFGAYIVL
560 570 580 590 600
LRQTRPPKGW LESMEEPTQT GSNLHMLRGQ VPLVIKALQR QLKDRSVRAR
610 620 630 640 650
QGCFSLLTEL AGVLPGSLGE HMPVLVAGIV FSLADRSSSS TIRMDALAFL
660 670 680 690 700
QGLLGTEPAE AFHSHLPTLL PPVMACVADP FYKIAAEALL VLQELVRALW
710 720 730 740 750
PLDRPRTLDP EPYVGEMSAA TLARLRATDL DQEVKERAIA CMGHLMAHLG
760 770 780 790 800
DRLGVDLEPS LLLLLDRLRN EITRLPAVKA LTLVAVSPLR LDLQPIVAEA
810 820 830 840 850
LPILASFLRK NQRALRLATL AALDALAQSQ GLSLPPCAVQ AVLAELPALV
860 870 880 890 900
SESDMHVAQL AVDFLATVTH AQPASLAKVS GPVLSELLRL LRSPLLPASV
910 920 930 940 950
LAAAEGFLQA LVGTRPPCVD YEELISMLTA PVYDQAADGG PGLHKQVFHS
960 970 980 990 1000
LARCVAALAA ACPQEAAGTA NRLVCDARSP HSSTGVKVLA FLSLAEVGQV
1010 1020 1030 1040 1050
AGPGPQRELK AVLLEALGSP SEDVRAAASY ALGRVGAGNL PDFLPFLLGQ
1060 1070 1080 1090 1100
IEAEPRRQYL LLHSLREALG AAQPDSLKPY AEDIWALLFQ RCEGAEEGTR
1110 1120 1130 1140 1150
GVVAECIGKL VLVNPPFLLP RFRKQLAAGQ PHTRSTVITA VKFLISDQPH
1160 1170 1180 1190 1200
PIDPLLKSFI GEFMESLQDP DLNVRRATLA FFNSAVHNKP SLVRDLLDDI
1210 1220 1230 1240 1250
LPLLYQETKI RRDLIREVEM GPFKHTVDDG LDVRKAAFEC MYSLLESCLG
1260 1270 1280 1290 1300
QLDICEFLNH VEDGLKDHYD IRMLTFIMLA RLATLCPAPV LQRVDRLIEP
1310 1320 1330 1340 1350
LRATCTAKVK AGSVKQEFEK QDELKRSAMR AVAALLTIPE VGKSPIMADF
1360 1370 1380
SSQIRSNPEL AALFESIQKD SASAPSTDSM DLS
Length:1,383
Mass (Da):149,759
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD674F0F4E07BCB8B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03012060 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000007922; ENSCAFP00000007344; ENSCAFG00000004904

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03012060 Genomic DNA No translation available.

3D structure databases

SMRiE2RFC3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000007344

Proteomic databases

PaxDbiE2RFC3

Genome annotation databases

EnsembliENSCAFT00000007922; ENSCAFP00000007344; ENSCAFG00000004904

Organism-specific databases

VGNCiVGNC:54586 CAND2

Phylogenomic databases

eggNOGiKOG1824 Eukaryota
ENOG410XPK4 LUCA
GeneTreeiENSGT00390000017740
InParanoidiE2RFC3
OMAiCMAALIS
TreeFamiTF300355

Gene expression databases

BgeeiENSCAFG00000004904 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2RFC3_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2RFC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: October 16, 2019
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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