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Entry version 56 (16 Jan 2019)
Sequence version 1 (30 Nov 2010)
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Protein
Submitted name:

Ubiquitin protein ligase E3 component n-recognin 4

Gene

UBR4

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1655 – 1728UBR-typePROSITE-ProRule annotationAdd BLAST74

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-6798695 Neutrophil degranulation
R-CFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin protein ligase E3 component n-recognin 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBR4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:48091 UBR4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E2RF02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000015314 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9615.ENSCAFP00000022600

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1655 – 1728UBR-typeInterPro annotationAdd BLAST74

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1655 – 1728UBR-typePROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1776 Eukaryota
ENOG410XPP8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00600000084471

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E2RF02

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEPHEYL

Database of Orthologous Groups

More...
OrthoDBi
717at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314406

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
IPR036322 WD40_repeat_dom_sf
IPR003126 Znf_UBR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
PF02207 zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E2RF02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSGGEEAA AAAPAPGASA TGADTTPGWE VAVRPLLSAS YSAFEMKELP
60 70 80 90 100
QLVASVIESE SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV
110 120 130 140 150
AAACKVLIEF SLLRLENPDE ACAVSQKHLI LLIKGLCTGC SRLDRTEMIT
160 170 180 190 200
FTAMMKSAKL PQTVKTLSDV EDQKELASPV SPELRQKEVQ MNFLNQLTSV
210 220 230 240 250
FNPRTVASPP GGPHTPAEGE NDEQSSTDQA SAIKTKNVFI AQNVASLQEL
260 270 280 290 300
GGSEKLLRVC LNLPYFLRYI NRFQDAVSAN SFFIMPATVA DATAVRNGFH
310 320 330 340 350
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL
360 370 380 390 400
HVGSAQQVRT GSTSSKEEDY ESDAATIVQK CLEIYDMIGQ AISNSRRAGG
410 420 430 440 450
EHYQNFQLLG AWCLLNSLFL ILNLSPTALA DKGKEKDPLA ALRVRDILSR
460 470 480 490 500
TKEGVGSPKL GPGKGHQGFG VLSVILANHA VKLLTSLFQD LQVEALHKAW
510 520 530 540 550
ETDGPPAVLN IMAQSTSIQR IQRLIDSVPL TNLLLTLLST SYRKACVLQR
560 570 580 590 600
QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS
610 620 630 640 650
PSKEKVAPPP PPPPPPLESS PRVKSPSKQA PGEKGNILAS RKDPELFLGL
660 670 680 690 700
ASNILNFITS SMLNSRNNFI RNYLSVSLSE HHMATLASII KEVDKDGLKG
710 720 730 740 750
SSDEEFAAAL YHFNHSLVTS DLQSPNLQNT LLQQLGVAPF SEGPWPLYIH
760 770 780 790 800
PQSLSVLSRL LLIWQHKAGT QGDPDVPECL KVWDRFLSTM KQNALQGVVP
810 820 830 840 850
NETEDLNVEH LQLLLLIFHN FTEKGRRAIL TLFVQIIQEL SANVDAQARS
860 870 880 890 900
VPLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WANGSQDSNS
910 920 930 940 950
RRVTTPLYHG FKEVEENWSK HFSSDAVPQP RFYCVLSPEA SEDDLNRLDS
960 970 980 990 1000
VACDVLFSKL VKYDELYTAL TCLLAAGSQL DTVRRKENKN VTALEACALQ
1010 1020 1030 1040 1050
YYFLILWRIL GILPPSKTYM NQLAMNSPEM SECDILHTLR WSSRLRISSY
1060 1070 1080 1090 1100
VNWIKDHLIK QGMKPEHAGS LLDLASTKCS SVKYDVEIVE EYFARQISSF
1110 1120 1130 1140 1150
CSIDCTTILQ LHEIPSLQSI YTLDAAISKV QVSLDEHFSK MAAETDPHKS
1160 1170 1180 1190 1200
SEITKNLLPA TLQLIDTYAS FTRAYLLQNF NEEGSTEKPS QEKLHGFAAV
1210 1220 1230 1240 1250
LAIGSSRCKA NTLGPTLVQN LPSWVQAVCE SWNNISTNEF PNIGSWRNAF
1260 1270 1280 1290 1300
ANDTIPSESY ISAVQAAHLG TLCGQSLPLA ASLKHTLLSL VRLTGDLIVW
1310 1320 1330 1340 1350
SDEMNPPQVI RTLLPLLLES STESVAEISS NSLERILGPA ESEEFLARVY
1360 1370 1380 1390 1400
EKLITGCYNI LANHADPNSG LDESILEECL QYLEKQLESS QARKAMEEFF
1410 1420 1430 1440 1450
SDSGELVQIM MATANENLSA KFCNRVLKFF TKLFQLTEKS PNPSLLHLCG
1460 1470 1480 1490 1500
SLAQLACVEP TRLQAWLTRM TASPPKDSDQ LDVIQENRQL LQLLTTYIVR
1510 1520 1530 1540 1550
ENSQVGEGVC AVLLGTLIPM ATEMLANGDG TGFPELMVVM ATLASAGQGA
1560 1570 1580 1590 1600
GHLQLHNAAV DWLSRCKKYL SQKNVVEKLN ANVMHGKHVI VLECTCHIMS
1610 1620 1630 1640 1650
YLADVTNALS QSNGQGPSHL SVDGEERAIE VDSDWVEELA VEEEDSQAED
1660 1670 1680 1690 1700
SDEDSLCNKL CTFTITQKEF MNQHWYHCHT CKMVDGVGVC TVCAKVCHKD
1710 1720 1730 1740 1750
HEISYAKYGS FFCDCGAKED GSCLALVKRT PSSGMSSTMK ESAFQSEPRV
1760 1770 1780 1790 1800
SESLVRHTST SPADKAKVTI SDGKVADEEK PKKSSLCRTV EGCREELQNQ
1810 1820 1830 1840 1850
ANFSFAPLVL DMLNFLMDAI QTNFQQASAV GSSSRAQQAL RELHTVDKVV
1860 1870 1880 1890 1900
EMTDQLMVPT LGSQEGAFEN VRMNYSGDQG QTIRQLISAH VLRRVAMCVL
1910 1920 1930 1940 1950
SSPHGRRQHL AVSHEKGKIT VLQLSALLKQ ADSSKRKLTL TRLASAPVPF
1960 1970 1980 1990 2000
TVLSLTGNPC KEDYLAVCGL KDCHVLTFSS SGSVSDHLVL HPQLATGNFI
2010 2020 2030 2040 2050
IKAVWLPGSQ TELAIVTADF VKIYDLSVDA LSPTFYFLLP SSKIRDVTFL
2060 2070 2080 2090 2100
FNEEGKNIIV IMSSAGYIYT QLMEEASSAQ QGPFYVTNVL EINHEDLKDS
2110 2120 2130 2140 2150
NSQVAGGGVS VYYSHVLQML FFSYCQGRSF AATVSRTTLE VLQLFSINIK
2160 2170 2180 2190 2200
SSNGGSKTSP ALCQWSEVMN HPGLVCCVQQ TTGVPLVVMV KPDTFLIQEI
2210 2220 2230 2240 2250
KTLPAKAKIQ DMVAIRHTAC NEQQRTTMIL LCEDGSLRIY MANVENTSYW
2260 2270 2280 2290 2300
LQPSLQPSSV ISIMKPVRKR KTATITTRTS SQVTFPIDFF EHNQQLTDVE
2310 2320 2330 2340 2350
FGGNDLLQVY NAQQIKHRLN STGMYVANTK PGGFTIEISN NNSTMVMTGM
2360 2370 2380 2390 2400
RIQIGTQAIE RAPSYIEIFG RTMQLNLSRS RWFDFPFTRE EALQADKKLN
2410 2420 2430 2440 2450
LFIGASVDPA GVTMIDAVKI YGKTKEQFGW PDEPPEEFPS ASVSNICPSN
2460 2470 2480 2490 2500
LNQSNGTGDS DPAAPATTSG TVLERLVVSS LEALESCFAV GPIIEKERNK
2510 2520 2530 2540 2550
NAAQELATLL LSLPAPASVQ QQSKSLLASL HTSRSAYHSH KDQALLSKAV
2560 2570 2580 2590 2600
QCLNTSSREG KDLDPEVFQR LVITARSIAI MRPNNLVHFT ESKLPPMETE
2610 2620 2630 2640 2650
GVDEGREPQK QLEGDCCSFI TQLVNHFWKL HASKPKNAFL APACLPGLTH
2660 2670 2680 2690 2700
IEATVNALVD IIHGYCTCEL DCINTASKIY MQMLLCPDPA VSFSCKQALI
2710 2720 2730 2740 2750
RVLRPRNKRR HVTLPSSPRS NTPMGDKDDD DDDDADDKMQ SSGIPNGGHI
2760 2770 2780 2790 2800
RQESQEQSEV DHGDFEMVSE SMVLETAENV NNGNPSPLEA LLAGAEGFPP
2810 2820 2830 2840 2850
MLDIPPDADD ETMVELAIAL SLQQDQQGSS SSALGLQSLG LSGQAPSSSS
2860 2870 2880 2890 2900
LDAGTLSDTT ASAPASDDEG STAATDGSTL RTSPADHGGS VGSESGGSAV
2910 2920 2930 2940 2950
DSVAGEHSVS GRSSAYGDAT VEGHPAGPGS VSSSTGAIST TTGHQEGDGS
2960 2970 2980 2990 3000
EGEGEGEGEG DVHTSNRLHM VRLMLLERLL QTLPQLRNVG GVRAIPYMQV
3010 3020 3030 3040 3050
ILMLTTDLDG EDEKDKGALD NLLSQLIAEL GMDKKDVSRK NERSALNEVH
3060 3070 3080 3090 3100
LVVMRLLSVF MSRTKSGSKS SICESSSLIS SATAAALLSS GAVDYCLHVL
3110 3120 3130 3140 3150
KSLLEYWKSQ QNDEEPVATS QLLKPHTTSS PPDMSPFFLR QYVKGHAADV
3160 3170 3180 3190 3200
FEAYTQLLTE MVLRLPYQIK KIADTNSRIP PPVFDHSWFY FLSEYLMIQQ
3210 3220 3230 3240 3250
TPFVRRQVRK LLLFICGSKE KYRQLRDLHT LDSHVRGIKK LLEEQGIFLR
3260 3270 3280 3290 3300
ASVVTASSGS ALQYDTLISL MEHLKACAEI AAQRTVNWQK FCIKDDSVLY
3310 3320 3330 3340 3350
FLLQVSFLVD EGVSPVLLQL LSCALCGSKV LAALAASAGS SSASSSTAPV
3360 3370 3380 3390 3400
AASSGQATTQ SKSSTKKSKK EEKEKEKEGE SSGSQEDQLC TALVNQLNKF
3410 3420 3430 3440 3450
ADKETLVQFL RCFLLESNSS SVRWQAHCLT LHIYRNSSKS QQELLLDLMW
3460 3470 3480 3490 3500
SIWPELPAYG RKAAQFVDLL GYFSLKTPQT EKKLKEYSQK AVEILRTQNH
3510 3520 3530 3540 3550
ILTNHPNSNI YNTLSGLVEF DGYYLESDPC LVCNNPEVPF CYIKLSSIKV
3560 3570 3580 3590 3600
DTRYTTTQQV VKLIGSHTIS KVTVKIGDLK RTKMVRTINL YYNNRTVQAI
3610 3620 3630 3640 3650
VELKNKPARW HKAKKVQLTP GQTEVKIDLP LPIVASNLMI EFADFYENYQ
3660 3670 3680 3690 3700
ASTETLQCPR CSASVPANPG VCGNCGENVY QCHKCRSINY DEKDPFLCNA
3710 3720 3730 3740 3750
CGFCKYARFD FMLYAKPCCA VDPIENEEDR KKAVSNINTL LDKADRVYHQ
3760 3770 3780 3790 3800
LMGHRPQLEN LLCKVNEAAP EKPQDDSGTA GGISSTSASV NRYILQLAQE
3810 3820 3830 3840 3850
YCGDCKNSFD ELSKIIQKVF ASRKELLEYD LQQREAATKS SRTSVQPTFT
3860 3870 3880 3890 3900
ASQYRALSVL GCGHTSSTKC YGCASAVTEH CITLLRALAT NPALRHILVS
3910 3920 3930 3940 3950
QGLIRELFDY NLRRGSAGMR EEVRQLMCLL TRDNPEATQQ MNDLIIGKVS
3960 3970 3980 3990 4000
TALKGHWANP DLASSLQYEM LLLTDSISKE DSCWELRLRC ALSLFLMAVN
4010 4020 4030 4040 4050
IKTPVVVENI TLMCLRILQK LIKPPAPTSK KNKDVPVEAL TTVKPYCNEI
4060 4070 4080 4090 4100
HAQAQLWLKR DPKASYESWK KCLPIRGIDG NGKSPSKSEL RHLYLTEKYV
4110 4120 4130 4140 4150
WRWKQFLSRR GKRTPPLDLK LGHNNWLRQV LFTPATQAAR QAACTIVEAL
4160 4170 4180 4190 4200
ATIPSRKQQV LDLLTSYLDE LSIAGECAAE YLALYQKLIT SAHWKVYLAA
4210 4220 4230 4240 4250
RGVLPYVGNL ITKEIARLLA LEEATLSTDL QQGYALKSLT GLLSSFVEVE
4260 4270 4280 4290 4300
SIKRHFKSRL VGTVLNGYLC LRKLVVQRTK LIDETQDMLL EMLEDMTTGT
4310 4320 4330 4340 4350
ESETKAFMAV CIETAKRYNL DDYRTPVFIF ERLCSIIYPE ENEVTEFFVT
4360 4370 4380 4390 4400
LEKDPQQEDF LQGRMPGNPY SSNEPGIGPL MRDIKNKICQ DCDLVALLED
4410 4420 4430 4440 4450
DSGMELLVNN KIISLDLPVA EVYKKVWCTT NEGEPMRIVY RMRGLLGDAT
4460 4470 4480 4490 4500
EEFIESLDST TDEEEDEEEV YKMAGVMAQC GGLECMLNRL AGIKDFKQGR
4510 4520 4530 4540 4550
HLLTVLLKLF SYCVKVKVNR QQLVKLEMNT LNVMLGTLNL ALVAEQESKD
4560 4570 4580 4590 4600
SGGATVAEQV LSIMEIILDE SNAEPLSEDK GNLLLTGDKD QLVMLLDQIN
4610 4620 4630 4640 4650
STFVRSNPSV LQGLLRIIPY LSFGELEKMQ ILVERFKPYC SFDKYDEDHS
4660 4670 4680 4690 4700
GDDKVFLDCF CKIAAGIKNS SNGHQLKDLI LQKGITQSAL DYMKKHIPSA
4710 4720 4730 4740 4750
KNLDADIWKK FLSRPALPFI LRLLRGLAVQ HPATQVLIGT DSITNLHKLE
4760 4770 4780 4790 4800
QVSSDEGIGT LAENLLEALR EHPDVNKKID AARRETRAEK KRMAMAMRQK
4810 4820 4830 4840 4850
ALGTLGMTTN EKGQVVTKTA LLKQMEELIE EPGLTCCICR EGYKFQPTKV
4860 4870 4880 4890 4900
LGIYTFTKRV ALEEMENKPR KQQGYSTVSH FNIVHYDCHL AAVRLARGRE
4910 4920 4930 4940 4950
EWESAALQNA NTKCNGLLPV WGPHVPESAF ATCLARHNTY LQECTGQREP
4960 4970 4980 4990 5000
TYQLNIHDIK LLFLRFAMEQ SFSADTGGGG RESNIHLIPY IIHTVLYVLN
5010 5020 5030 5040 5050
TTRATSREEK NLQGFLEQPK EKWVESAFEV DGPHYFTVLA LHILPPEKWR
5060 5070 5080 5090 5100
ATRVEILRRL LVTSQARAVA PGGATRLTDK AVKDYSAYRS SLLFWALVDL
5110 5120 5130 5140 5150
IYNMFKKVPT SNTEGGWSCS LAEYIRHNDM PIYEAADKAL KTFQEEFMPV
5160 5170 5180
ETFSEFLDAA GLLSEVTDPE NFLKDLLNSI P
Length:5,181
Mass (Da):573,445
Last modified:November 30, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06024D54AB55B81B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03001814 Genomic DNA No translation available.
AAEX03001815 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_853095.1, XM_848002.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSCAFT00000024347; ENSCAFP00000022600; ENSCAFG00000015314

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
478211

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001814 Genomic DNA No translation available.
AAEX03001815 Genomic DNA No translation available.
RefSeqiXP_853095.1, XM_848002.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022600

Proteomic databases

PaxDbiE2RF02

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000024347; ENSCAFP00000022600; ENSCAFG00000015314
GeneIDi478211

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23352
VGNCiVGNC:48091 UBR4

Phylogenomic databases

eggNOGiKOG1776 Eukaryota
ENOG410XPP8 LUCA
GeneTreeiENSGT00600000084471
InParanoidiE2RF02
OMAiDEPHEYL
OrthoDBi717at2759
TreeFamiTF314406

Enzyme and pathway databases

ReactomeiR-CFA-6798695 Neutrophil degranulation
R-CFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSCAFG00000015314 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
IPR036322 WD40_repeat_dom_sf
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2RF02_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2RF02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

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