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Protein
Submitted name:

von Hippel-Lindau disease tumor suppressor

Gene

VHL

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-168638 NOD1/2 Signaling Pathway
R-CFA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-CFA-450302 activated TAK1 mediates p38 MAPK activation
R-CFA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-CFA-9020702 Interleukin-1 signaling
R-CFA-937042 IRAK2 mediated activation of TAK1 complex
R-CFA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-CFA-975155 MyD88 dependent cascade initiated on endosome
R-CFA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Names & Taxonomyi

Protein namesi
Submitted name:
von Hippel-Lindau disease tumor suppressorImported
Gene namesi
Name:VHLImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 20

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSCAFG00000005140

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 94DeathInterPro annotationAdd BLAST68
Domaini206 – 552Protein kinaseInterPro annotationAdd BLAST347

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
TreeFamiTF328924

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033611 IRAK2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PANTHERiPTHR24419:SF2 PTHR24419:SF2, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

E2RDA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCYIYQLPA WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER
60 70 80 90 100
VQGVSITREL LWWWGMRQAT VQQLVDLLRR LQLYRAAQII LNWKPVPEIN
110 120 130 140 150
CSFLDFPEAV KPGRPLEASV RTMEDEQEKG PSVRPADFPG PGPAPARTNL
160 170 180 190 200
LPPSADAPHS LKTDVPVSSN SKDFSTSIPK QETLLSLAGD SLFWSETDVV
210 220 230 240 250
QATDNFNQNY KISEGNFADI YKGQKHGTLF VFKKLREAAY SGPGSIEKFF
260 270 280 290 300
QAEVQICHRC CHPNILPLLG FCTGNQLYIL IYPYMANGSL QDRLQDQDGS
310 320 330 340 350
EPLLWPQRAS ICSGLLRAVE HLHGLGIIHG NVKSSNVLLD QNFIPKLAHP
360 370 380 390 400
IAHLCSDNKR SKYTMMKTHL FQASAAYLPE DFIRVGQLTK RVDIFSCGIV
410 420 430 440 450
LAEVLTGIPA MDNNRSPVYL KDLLLGEIPS STTSLGCRKT GVEKVMAKEI
460 470 480 490 500
CRKYLEKRAG RLLEDCAETL ALAACLCLRR RNACLAEVCG SVAAVEERLR
510 520 530 540 550
GQETLLPSSG LSEGTSSSSN TPEETDDVDN SSLDASYSMR VAPGAGAAAS
560 570 580 590 600
FLPTEDGEGR LQVCGGMQAD SSSVACAGPE PPQDATTETS WKIEINEAKR
610 620
KLMENILYYK EGKLDSIELL GP
Length:622
Mass (Da):68,838
Last modified:October 31, 2012 - v2
Checksum:iCA3DFCEF4CA0EE07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03012078 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000008287; ENSCAFP00000007680; ENSCAFG00000005140

Similar proteinsi

Entry informationi

Entry nameiE2RDA4_CANLF
AccessioniPrimary (citable) accession number: E2RDA4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: March 28, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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