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UniProtKB - E2RB82 (E2RB82_CANLF)

Entry version 77 (10 Feb 2021)
Sequence version 2 (31 Oct 2012)
Previous versions | rss
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Protein

Signal transducer and activator of transcription

Gene

STAT3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CFA-1059683, Interleukin-6 signaling
R-CFA-1266695, Interleukin-7 signaling
R-CFA-1433557, Signaling by SCF-KIT
R-CFA-186763, Downstream signal transduction
R-CFA-6783783, Interleukin-10 signaling
R-CFA-6785807, Interleukin-4 and Interleukin-13 signaling
R-CFA-8854691, Interleukin-20 family signaling
R-CFA-8983432, Interleukin-15 signaling
R-CFA-8984722, Interleukin-35 Signalling
R-CFA-8985947, Interleukin-9 signaling
R-CFA-9008059, Interleukin-37 signaling
R-CFA-9020933, Interleukin-23 signaling
R-CFA-9020956, Interleukin-27 signaling
R-CFA-9020958, Interleukin-21 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAT3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:46890, STAT3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E2RB82

PRoteomics IDEntifications database

More...PRIDEi		E2RB82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSCAFG00000015213, Expressed in adrenal gland and 51 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9612.ENSCAFP00000022438

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E2RB82

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini580 – 670SH2InterPro annotationAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili141 – 168Sequence analysisAdd BLAST28
Coiled coili270 – 290Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3667, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014189_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E2RB82

Identification of Orthologs from Complete Genome Data

More...OMAi		GKYCRSE

Database of Orthologous Groups

More...OrthoDBi		327469at2759

TreeFam database of animal gene trees

More...TreeFami		TF318648

Family and domain databases

Conserved Domains Database

More...CDDi		cd10374, SH2_STAT3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR035855, STAT3_SH2
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction

The PANTHER Classification System

More...PANTHERi		PTHR11801, PTHR11801, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00017, SH2, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00964, STAT_int, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47655, SSF47655, 1 hit
SSF48092, SSF48092, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E2RB82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAS HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRSIVSE LAGLLSTMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTSNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720        730        740        750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG 
       760        770
QFETLTFDME LTSECATSPM
Length:770
Mass (Da):88,058
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AA8ED22EB3F5D28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F4CC58A0A5F4CC58_CANLF
Signal transducer and activator of ...
STAT3
793Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAEX03006447 Genomic DNA No translation available.
AAEX03006448 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_005624514.1, XM_005624457.2
XP_005624515.1, XM_005624458.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCAFT00000024171; ENSCAFP00000022438; ENSCAFG00000015213

Database of genes from NCBI RefSeq genomes

More...GeneIDi		490967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cfa:490967

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006447 Genomic DNA No translation available.
AAEX03006448 Genomic DNA No translation available.
RefSeqiXP_005624514.1, XM_005624457.2
XP_005624515.1, XM_005624458.2

3D structure databases

SMRiE2RB82
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000022438

Proteomic databases

PaxDbiE2RB82
PRIDEiE2RB82

Genome annotation databases

EnsembliENSCAFT00000024171; ENSCAFP00000022438; ENSCAFG00000015213
GeneIDi490967
KEGGicfa:490967

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6774
VGNCiVGNC:46890, STAT3

Phylogenomic databases

eggNOGiKOG3667, Eukaryota
GeneTreeiENSGT00990000203570
HOGENOMiCLU_014189_3_0_1
InParanoidiE2RB82
OMAiGKYCRSE
OrthoDBi327469at2759
TreeFamiTF318648

Enzyme and pathway databases

ReactomeiR-CFA-1059683, Interleukin-6 signaling
R-CFA-1266695, Interleukin-7 signaling
R-CFA-1433557, Signaling by SCF-KIT
R-CFA-186763, Downstream signal transduction
R-CFA-6783783, Interleukin-10 signaling
R-CFA-6785807, Interleukin-4 and Interleukin-13 signaling
R-CFA-8854691, Interleukin-20 family signaling
R-CFA-8983432, Interleukin-15 signaling
R-CFA-8984722, Interleukin-35 Signalling
R-CFA-8985947, Interleukin-9 signaling
R-CFA-9008059, Interleukin-37 signaling
R-CFA-9020933, Interleukin-23 signaling
R-CFA-9020956, Interleukin-27 signaling
R-CFA-9020958, Interleukin-21 signaling

Gene expression databases

BgeeiENSCAFG00000015213, Expressed in adrenal gland and 51 other tissues

Family and domain databases

CDDicd10374, SH2_STAT3, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR035855, STAT3_SH2
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction
PANTHERiPTHR11801, PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit
SMARTiView protein in SMART
SM00964, STAT_int, 1 hit
SUPFAMiSSF47655, SSF47655, 1 hit
SSF48092, SSF48092, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2RB82_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2RB82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: February 10, 2021
This is version 77 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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