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Protein

Galactose-1-phosphate uridylyltransferase

Gene

GALT

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.PROSITE-ProRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184ZincPROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediateUniRule annotation1
Metal bindingi202IronUniRule annotation1
Metal bindingi301IronUniRule annotation1
Metal bindingi319IronUniRule annotation1
Metal bindingi321IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processCarbohydrate metabolism, Galactose metabolismUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-CFA-70370 Galactose catabolism
UniPathwayi
UPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferaseUniRule annotation (EC:2.7.7.12UniRule annotation)
Gene namesi
Name:GALTImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:41103 GALT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2RB65

Expressioni

Gene expression databases

BgeeiENSCAFG00000001946 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000002867

Structurei

3D structure databases

ProteinModelPortaliE2RB65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 196GalP_UDP_transfInterPro annotationAdd BLAST173
Domaini203 – 368GalP_UDP_tr_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
InParanoidiE2RB65
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
TreeFamiTF300018

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit

Sequencei

Sequence statusi: Complete.

E2RB65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSGSPPDQ RQQASEADAT ATTFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPP LLMTVPRHDP HNPLCPGATR ANGEVNPYYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPNPG PSDHPLFQAE AARGVCKVMC FHPWSDVTLP LMSVPEIRTV
160 170 180 190 200
VDAWASVTEE LGARYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQRAYQ SQHGEPLLME YGRQELLRKE RLVLTSEHWL VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VRRLPELTPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGSEAE ANWDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370 380
PEQAAERLRM LPEVHYRLGQ QKDRETATIA
Length:380
Mass (Da):43,685
Last modified:November 30, 2010 - v1
Checksum:i1A65D1B0AB9D19C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03007945 Genomic DNA No translation available.
RefSeqiXP_852579.1, XM_847486.3

Genome annotation databases

EnsembliENSCAFT00000003087; ENSCAFP00000002867; ENSCAFG00000001946
GeneIDi474751

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03007945 Genomic DNA No translation available.
RefSeqiXP_852579.1, XM_847486.3

3D structure databases

ProteinModelPortaliE2RB65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000002867

Proteomic databases

PaxDbiE2RB65

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000003087; ENSCAFP00000002867; ENSCAFG00000001946
GeneIDi474751

Organism-specific databases

CTDi2592
VGNCiVGNC:41103 GALT

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
InParanoidiE2RB65
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
TreeFamiTF300018

Enzyme and pathway databases

UniPathwayi
UPA00214

ReactomeiR-CFA-70370 Galactose catabolism

Gene expression databases

BgeeiENSCAFG00000001946 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2RB65_CANLF
AccessioniPrimary (citable) accession number: E2RB65
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 10, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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