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Entry version 60 (05 Jun 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Ring finger protein 213

Gene

RNF213

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ring finger protein 213Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF213Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:45657 RNF213

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E2R819

PRoteomics IDEntifications database

More...
PRIDEi
E2R819

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000005675 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000008493

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3244 – 3282RING-typeInterPro annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2729 – 2769DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili650 – 670Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHNB Eukaryota
ENOG410XTAN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00630000089884

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E2R819

Identification of Orthologs from Complete Genome Data

More...
OMAi
SARHLEW

TreeFam database of animal gene trees

More...
TreeFami
TF329577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR031248 RNF213
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR22605 PTHR22605, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00097 zf-C3HC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E2R819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VKLMSKYIHL LNVDTYLFRS WFSLVPLSNL LDYMENFVEY QSHIPACILD
60 70 80 90 100
CLQGTWYRLQ HHTKLSKRHQ EPQNIGKILT RLLDLLNIYQ DKILEEPLIQ
110 120 130 140 150
SYLTVCQKLH ETICSITKDE RLYELLALSA EIVCRIITLQ PLVDSAEGLG
160 170 180 190 200
KEARRNSVHA VFQGTIINTR AWLQSVFRER IFNIIGARAV LTFRYTDEIK
210 220 230 240 250
VWRQLMKINF PVEYGWKESL LEDLEGRIKQ EKPFDQICIF CGPQWDARGQ
260 270 280 290 300
EDSVSKCFEK CVVEAVSAAS QNQTSILERI SYHNLQNFGT LVSAVITKSW
310 320 330 340 350
PRNEDAPCYL DEVLKHLLTC PDIKHLFKLC RTNQKILANI TEDSKELLAT
360 370 380 390 400
GSSVFMKVGE DLLHGTILVR HLELIEKHTD QFLGIWESER KSLSSLENEH
410 420 430 440 450
NVGEVLVWRK DELSSLKREK KCVSSLLSMC EKVKQLVQGF KVDLEKMVEK
460 470 480 490 500
NLEDLGSKRL CDVVTVRLSS SSPDVKRTVH YNLSPHIQEM AEKVDQLKDS
510 520 530 540 550
HIFQVFWENT TEGLRKPEEE LEQQILQLEE VYTYLYVPCF KKFMKLYEDL
560 570 580 590 600
RSGKITFQEV NTVFKDFVNK YSNLTSDLRT MCALDPSDQQ DWIEDRVAQI
610 620 630 640 650
QEYHHLDQAV SSAKVILEVK ENLGLIGNFS ILHTLLHFTD NFDKYRHEKL
660 670 680 690 700
ERISRELINA KKLLEDISET RSQCLKELAL RKEFISWVRE ALGGINELKV
710 720 730 740 750
FVDLASISAG ENDIDVDRVA CFHDAVQGSA SLLYKLDTSA GFNEFMMHLK
760 770 780 790 800
EMWKALEKDP HLPHKLRDSA RNLEWLKTVR ESHGSVELSS LSLATAINTK
810 820 830 840 850
GIYMIGAPTD GQKISPDTVL QLLLPESHGD HEEVRVYSLE QLKELLNKLM
860 870 880 890 900
LMSGKKDHGN VQVEVFSKVF SNVQRLVQSF INLYCAGNML FRAWKAEVYC
910 920 930 940 950
SPRHGVSLRM DFCLTLINQL KGTGPVVELL EAVSRQMEDF LDHWISFVAE
960 970 980 990 1000
KRAKHFYLNY YTAEQLVYLS TQLKEQKPST AALTMLSFIK GNCTLRDVKE
1010 1020 1030 1040 1050
ALRGSSGKAA RHHERTAAEG LRQALPHEFS LVDKLRAILE QSMVCMSAFL
1060 1070 1080 1090 1100
PHCLDLEALG LYLASLARMN RHPVERDLPK GLHVGQPNLI VCGHSEVLPA
1110 1120 1130 1140 1150
ALAIYRHMEN EPLPTFDEML LCTPGTTFEE VALLLRRCLT PGSRGRGIYS
1160 1170 1180 1190 1200
LLYADLLSYE VACQAETLFL NLCLQSHQGD FQLVMICDSQ REHCHLPSAF
1210 1220 1230 1240 1250
SQHKVLITPQ APLQDIQAYL AKHFQVPENM PSAADVFRDR MCVGVVTSKR
1260 1270 1280 1290 1300
AGVGKSLYVE RLHSKLERKL RDKEVPLKVI RLIDPQVDEK KVLSSLLPFL
1310 1320 1330 1340 1350
KSYYQTMPVI FHFDVTSSVQ TGLWVFIFKL LILRYLMDIN GKIWLRNPRH
1360 1370 1380 1390 1400
LYIIEILETT PALPKAPSRR STHTPQFNFL DVFPKVTCRP PKEVINMELN
1410 1420 1430 1440 1450
PEESYNDPGM DLTVFRSETF QRPYQYLKRF HEKKNLDNFQ YQEGFVEGTP
1460 1470 1480 1490 1500
EECLQYFLIY CGVIDPSWSE LQNFAGFLNY QLRDCEASVF CNSHVVGDTL
1510 1520 1530 1540 1550
QGFKNFVVTF MIFMARDFAT PTLHTNDQSP GRHAVIMDGV RDEDLAPFSL
1560 1570 1580 1590 1600
RKRWESEPHP YVFFNGDHTS MTFIGFHIQS NRNASLDAIH PSSGRVIKKD
1610 1620 1630 1640 1650
VMGQKLYQGL LLQRVPFNVD FDQLPRQEKL AKLCLALGIQ CPIDPDDTYE
1660 1670 1680 1690 1700
ITTDNMLKIL AIEMRFRCGI PVIIMGETGC GKTRLVKFLS DLRCGSTKAE
1710 1720 1730 1740 1750
TMKLVKVHGG TTAEMIYAKV REAEKLALLN KEQHQLDTIL FFDEANTTEA
1760 1770 1780 1790 1800
ISCIKEVLCD HTVDGQPLVK DSGLQIIAAC NPYRKHSQEM ICRLESAGLG
1810 1820 1830 1840 1850
YRVRAVDTAE RLGSIPLRQL VYRVHALPPS LIPLVWDFGQ LNNNAEKLYI
1860 1870 1880 1890 1900
QQIMQRLVGS IRIDEDKTHV ITEVLSTSQG FMRTRVNECS FVSLRDVERC
1910 1920 1930 1940 1950
VRVFRWFYNR SEMLLAKLDS FLRQSHVSKN NFKRDPVLWS LVLALGVCYH
1960 1970 1980 1990 2000
ASLEQKEPYW KDICVFFPEP YNDSKVILEE ITQTQDLFLD GVSLRKTIAR
2010 2020 2030 2040 2050
NAALKENVFM MVICIELKIP LFLVGKPGSS KSLAKTVVAD AMQGPAAHSD
2060 2070 2080 2090 2100
LFRSLKQVHL VSFQCSPHST PQGIISTFKQ CARFQQEKDL YQYVSVVVLD
2110 2120 2130 2140 2150
EVGLAEDSPK MPLKALHPLL EYGCIEDNPA PHKKVGFIGI SNWALDPAKM
2160 2170 2180 2190 2200
NRGIFVSRGS PNKKELIESA KGICSSEPLV QKRVQGFFAP FAKAYETVCE
2210 2220 2230 2240 2250
KQDKEFFGLR DYYSLIKMVF AKAKASNKEP SPQDIAQAIL RNFSGKDDIH
2260 2270 2280 2290 2300
ALDIFTANLP EAKCSEEVST MQLIQQNMYG DLQTVPGREL DDSESRYLLV
2310 2320 2330 2340 2350
LTRNYAALQV LQQQMFFSEN QQPEIIFGSS FPRDQEYTQV CRNINRVKIC
2360 2370 2380 2390 2400
METGKMVVLL NLQSLYESLY DALNQYYVYL GGQKYVDLGL GTHRVKCRVH
2410 2420 2430 2440 2450
PDFRLIVIEE KDVVYKHFPI PLINRLEKHY LDINTVLEKW QKSIVEELKT
2460 2470 2480 2490 2500
WVENFVEVKT EQFIATHKYS PSEVFIGYHP DACASVVLQV TQRLGPNFPT
2510 2520 2530 2540 2550
DELYQKVSQE AKLVLLGCAT PDAVVRLGTT SLGLFTAQFL SREYYHKQQH
2560 2570 2580 2590 2600
NSFADFLQAQ LHAVDLERRV IFTEITTFSR LLTSHDCKIL ESEVMDGDVR
2610 2620 2630 2640 2650
PTILSLQQFD TESSFLRRVQ NCLTNVAKCK ILIIQMDFED GVRSAQLIAS
2660 2670 2680 2690 2700
AKYSAINEIN KIQGNEDRIL VYFITKLSRM ESGAAYVGFH GGLWQSVHID
2710 2720 2730 2740 2750
DLQKSTVMIA DVTKLQDVAI SQLFEPEEKP KREAMEIEAS ASGEAAEGSS
2760 2770 2780 2790 2800
APEGSWRGER GRSDLTVPPT QVLDTSSLLR SCVQGAVGML RDREEARPRG
2810 2820 2830 2840 2850
MQRVEILLGL LSEDDADRAA FLRVCKARLH RLLKHQEESS AFSRKDWVSR
2860 2870 2880 2890 2900
EASNQDALQE AGTFRQTLWK RVQGMVTPLL ASIVSVLDRD SNLELLIRQD
2910 2920 2930 2940 2950
APSWTRDLWM FIFQDTKLLN IPLVTYDMRS KSEMPYIMVH NDMSPPEGVS
2960 2970 2980 2990 3000
GDVPFSWRIK DYLEELWVQA QYITGAEAGL SKKLVEIFQQ TPLGRFLAQL
3010 3020 3030 3040 3050
SVKQQQELFV SYMKDFLLLT MRPSTWDQLN VLHMALWSCI NQLHTQRPDE
3060 3070 3080 3090 3100
QLSLPWVHLA YQHFRSRLQN LSRILTIYPQ ILQVLLCNMT ESTRNDRLDR
3110 3120 3130 3140 3150
NELTLDALAA VACTEVLTRD ILKPSPQAWL QMVKNLSMPL ELLGSKGYLQ
3160 3170 3180 3190 3200
SCGRMARDAI REVRIHWNRI FPVALFVEHV VLGVRNKIPE LQALVTDHLF
3210 3220 3230 3240 3250
LLNKYLQDDS DIKTYRPFVT VMHTLCKCKE QASKTLSRFE IQPCPVCLGD
3260 3270 3280 3290 3300
AQEPVSLPCG HVFCLRCINT CITLGQMACP YCLTDLPKDF SLTVNQEHRD
3310 3320 3330 3340 3350
AIRKHACLRQ MCNSFFLDLV STVCFKDNTP PEKDVIDVLL NLLFVQKEFL
3360 3370 3380 3390 3400
RDTPQRHCEH TKSLSPFDDI VDKTPVIRSV VLKLLLKYSF QEVKDYIQAY
3410 3420 3430 3440 3450
LSLLQQKALV TEDKTELYIL FSNCLEDSLY EKTSALSTSE ELRYLREEGA
3460 3470 3480 3490 3500
FLKTYSMWCS PEPASEASVE YLQEMTRIRL CLNKASDFLS ELQDSSETAR
3510 3520 3530 3540 3550
EKQCYLQQVE RFCRQAKNDW YRVYLVRKLS SQRGIEYVQQ FCAQGHPARW
3560 3570 3580 3590 3600
IFPEEALLRE VRTENMLSQM DRYLVHGDKY KALRDTVGKA ILQNEPLTTV
3610 3620 3630 3640 3650
AVLKGGRNHD PELAAHLLLV LFREVAVLYQ SCNTSLHPKP EQCEALNAFI
3660 3670 3680 3690 3700
EEGKIFSSPH MRHFAASLVN NTLPLLRTGP RDSSLQGTVA ELAVHTAAVL
3710 3720 3730 3740 3750
LCGQGDILEP LKSLAFSPAD MVNSYLPTMP EDLLVQARNW KGLETLSWYM
3760 3770 3780 3790 3800
CPNGHPCSVG ECGKPMEKSH CIDCGVQVGG VNHSPETGFH VITDKTDRTQ
3810 3820 3830 3840 3850
KGHVLGAPPS RDKVLVSDRE LAPDVFLLIR LLTHLALLLG ATQRPEAVMN
3860 3870 3880 3890 3900
IIKPPVRDPS SFLQRHIHRD LEQLAKTLGR SADEATTTVH LMLCSLLRGQ
3910 3920 3930 3940 3950
RRLSSWRPFC FKANLETREQ RNSWEKAMQT LLLPELEHLE KALLTVTASI
3960 3970 3980 3990 4000
SQDERISSNP VARIVYKDPT VFLPHLPGKS VFHCSKMWTC RRKVTVDYLQ
4010 4020 4030 4040 4050
HIVEQKNGKE SVPILWKFLQ KEAELRLVRF LPEILALQRD LVRRFQNASE
4060 4070 4080 4090 4100
ADYQSIRSFI SSHQGDGLKQ LFHRRIQIFL STWNKLRRSL QTNGEIKLPD
4110 4120 4130 4140 4150
SYCSADLDMD TNFEVILPRR RGLGLCSTAL VSYLISLHNE MVYAVGKFSD
4160 4170 4180 4190 4200
ENNSYSVDAS EVTDLHVISY EVEQDLMPLI LSNCQYQVEQ GKETLQEFDL
4210 4220 4230 4240 4250
EKIQRQVTSR FLQGKPRITL MGIPTLVYRR DWNYEQLFME IKNKMLQKPL
4260 4270 4280 4290 4300
PNATISSIRG QLPSYSDGCK ALSVIEVTLG FLSTAGGDPN MSLNEYVQDM
4310 4320 4330 4340 4350
LRMGDQAELV LKAFNRCQLK HAIALWQILS AHRSEQLLRL QKEPFREISS
4360 4370 4380 4390 4400
RYKVGLSPEN AKCLSTFLNQ MDLDAFLLEL HEMMILKLKS PQAEDNFRPE
4410 4420 4430 4440 4450
WSLRDTLVSY METKDSEIPP ELEYQFPEEI LLSNCVPAWS LAVGLKRARQ

AT
Length:4,452
Mass (Da):509,423
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3275E3025D77308F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9NYP9J9NYP9_CANLF
Ring finger protein 213
RNF213
4,036Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03006199 Genomic DNA No translation available.
AAEX03006200 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000009155; ENSCAFP00000008493; ENSCAFG00000005675

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006199 Genomic DNA No translation available.
AAEX03006200 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000008493

Proteomic databases

PaxDbiE2R819
PRIDEiE2R819

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000009155; ENSCAFP00000008493; ENSCAFG00000005675

Organism-specific databases

VGNCiVGNC:45657 RNF213

Phylogenomic databases

eggNOGiENOG410IHNB Eukaryota
ENOG410XTAN LUCA
GeneTreeiENSGT00630000089884
InParanoidiE2R819
OMAiSARHLEW
TreeFamiTF329577

Enzyme and pathway databases

ReactomeiR-CFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSCAFG00000005675 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR031248 RNF213
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR22605 PTHR22605, 2 hits
PfamiView protein in Pfam
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2R819_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2R819
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: June 5, 2019
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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