UniProtKB - E2R1Y1 (E2R1Y1_CANLF)
Protein
Submitted name:
Nuclear factor of activated T cells 1
Gene
NFATC1
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- calcineurin-NFAT signaling cascade Source: GO_Central
- cytokine production Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
Reactomei | R-CFA-2871809, FCERI mediated Ca+2 mobilization R-CFA-4086398, Ca2+ pathway R-CFA-5607763, CLEC7A (Dectin-1) induces NFAT activation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor of activated T cells 1Imported |
Gene namesi | Name:NFATC1Imported |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris)Imported |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:43766, NFATC1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- transcription regulator complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000000011, Expressed in cartilage tissue and 52 other tissues |
Interactioni
GO - Molecular functioni
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000000012 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 330 – 512 | RHDInterPro annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 220 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 674 – 837 | DisorderedSequence analysisAdd BLAST | 164 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 187 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 198 – 220 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 775 – 792 | PolarSequence analysisAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
InParanoidi | E2R1Y1 |
TreeFami | TF326480 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit PTHR12533:SF5, PTHR12533:SF5, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
E2R1Y1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAPAASQPP GYGGAVDTGP SSYFLSSGHI RPNGAPALES PRIEITSYLG
60 70 80 90 100
MHHSNSQFFH DVEVEDVLPS SKRPSSTATL NLPNLEAYRD PSCLSPASSL
110 120 130 140 150
SSRSCNSEAS SYESNFSYPY ASPQTSPWQS PCVSPKTTDP EEAFPRGLGA
160 170 180 190 200
CGLLSSPRHS PSTSPRTSIT EESWLGARTS RPSSPCNKRK YGLNGRQLSC
210 220 230 240 250
SPHHSPTPSP HSSPRVSITD DTWLGNSTQY TSSAIVAAIN ALTTDNSLEL
260 270 280 290 300
DGVPVKARKT APDHCPSVAL KVEPAGEDLG TTPPTAEFLP EEFTSFQHIR
310 320 330 340 350
KGAFCDQYLS VPQHPYQWAR PRSPTSFASP SLPALDWQLP SRSGPYELRI
360 370 380 390 400
EVQPKPHHRA HYETEGSRGA VKASAGGHPS VQLHGYLENE PLTLQLFIGT
410 420 430 440 450
ADDRLLRPHA FYQVHRITGK TVSTTSHEAI LSNTKVLEIP LLPENNMRAI
460 470 480 490 500
VDCAGILKLR NSDIELRKGE TDIGRKNTRV RLVFRVHIPQ PNGRTLSLQV
510 520 530 540 550
ASNPIECSQR SAQELPLVEK QSAASCPVLG GKKMVLSGHN FLQDSKVIFV
560 570 580 590 600
EKAPDGHHIW ETEAKLDRDL CKPNSLVVEI PPFRNQRITS PVQVSFYVCN
610 620 630 640 650
GKRKRSQYQH FTYLPANAPT IKTEPTDDYE PALPCGPASQ GLSPLPKSCY
660 670 680 690 700
SQQLAMPPDP GSCLVPGFPP CPQRSTVVSP PPSAGPKMHD LSSTTYSKGM
710 720 730 740 750
ASPGHGHLGL QRPAGGLLAA QETPTPAGVH AGPPQQPPPA LLRPQVSAQL
760 770 780 790 800
SSHCPLGRRP ALCPDSPSSS PPSGPQEPTC LQSCSPTRPS EMGPQQHRLP
810 820 830 840 850
KAPRSESAAP RPVPPPEVRE DSNHSLAPIP VTVKREPQEL DQLYLDDVNE
860
IIRNDLSSTN IRS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE2R9E9 | E2R9E9_CANLF | Nuclear factor of activated T cells... | NFATC1 | 923 | Annotation score: | ||
A0A5F4CLS1 | A0A5F4CLS1_CANLF | Nuclear factor of activated T cells... | NFATC1 | 766 | Annotation score: | ||
A0A5F4BUH6 | A0A5F4BUH6_CANLF | Nuclear factor of activated T cells... | NFATC1 | 740 | Annotation score: | ||
A0A5F4C5N8 | A0A5F4C5N8_CANLF | Nuclear factor of activated T cells... | NFATC1 | 732 | Annotation score: | ||
A0A5F4CRE9 | A0A5F4CRE9_CANLF | Nuclear factor of activated T cells... | NFATC1 | 730 | Annotation score: | ||
A0A5F4CWR0 | A0A5F4CWR0_CANLF | Nuclear factor of activated T cells... | NFATC1 | 750 | Annotation score: | ||
A0A5F4C3C6 | A0A5F4C3C6_CANLF | Nuclear factor of activated T cells... | NFATC1 | 841 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEX03000017 Genomic DNA No translation available. AAEX03000018 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSCAFT00000000013; ENSCAFP00000000012; ENSCAFG00000000011 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEX03000017 Genomic DNA No translation available. AAEX03000018 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000000012 |
Proteomic databases
PaxDbi | E2R1Y1 |
Genome annotation databases
Ensembli | ENSCAFT00000000013; ENSCAFP00000000012; ENSCAFG00000000011 |
Organism-specific databases
VGNCi | VGNC:43766, NFATC1 |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
InParanoidi | E2R1Y1 |
TreeFami | TF326480 |
Enzyme and pathway databases
Reactomei | R-CFA-2871809, FCERI mediated Ca+2 mobilization R-CFA-4086398, Ca2+ pathway R-CFA-5607763, CLEC7A (Dectin-1) induces NFAT activation |
Gene expression databases
Bgeei | ENSCAFG00000000011, Expressed in cartilage tissue and 52 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit PTHR12533:SF5, PTHR12533:SF5, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E2R1Y1_CANLF | |
Accessioni | E2R1Y1Primary (citable) accession number: E2R1Y1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2010 |
Last sequence update: | December 11, 2019 | |
Last modified: | August 12, 2020 | |
This is version 66 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |