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Protein

Tubulin beta chain

Gene

TUBB6

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-CFA-2132295 MHC class II antigen presentation
R-CFA-2467813 Separation of Sister Chromatids
R-CFA-2500257 Resolution of Sister Chromatid Cohesion
R-CFA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-CFA-380320 Recruitment of NuMA to mitotic centrosomes
R-CFA-437239 Recycling pathway of L1
R-CFA-5620924 Intraflagellar transport
R-CFA-5626467 RHO GTPases activate IQGAPs
R-CFA-5663220 RHO GTPases Activate Formins
R-CFA-6807878 COPI-mediated anterograde transport
R-CFA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-CFA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CFA-68877 Mitotic Prometaphase
R-CFA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-CFA-8955332 Carboxyterminal post-translational modifications of tubulin
R-CFA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBB6Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:47991 TUBB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiE2QYC2
PRIDEiE2QYC2

Expressioni

Gene expression databases

BgeeiENSCAFG00000018832

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027792

Structurei

3D structure databases

ProteinModelPortaliE2QYC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 244TubulinInterPro annotationAdd BLAST198
Domaini246 – 383Tubulin_CInterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili408 – 428Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061
InParanoidiE2QYC2
KOiK07375
OMAiAVFRGPM
OrthoDBiEOG091G06U2
TreeFamiTF300298

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit

Sequencei

Sequence statusi: Complete.

E2QYC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIVHIQAG QCGNQIGTKF WEVISDEHGI DPAGGYVGDS ALQLERINVY
60 70 80 90 100
YNESSSQKYV PRAALVDLEP GTMDSVRSGP FGQLFRPDNF IFGQTGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDAVLDVV RKECEHCDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRIMNTFSVM PSPKVSDTVV EPYNATLSVH QLVENTDETY
210 220 230 240 250
CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTSL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLTARGSQQ YRALTVPELT QQMFDAKNMM
310 320 330 340 350
AACDPRHGRY LTVAAVFRGP MSMKEVDEQM LAIQNKNSSY FVEWIPNNVK
360 370 380 390 400
VAVCDIPPRG LKMAATFIGN STAIQELFKR ISEQFSAMFR RKAFLHWFTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQDATA NDGEEAFEDD EEEINE
Length:446
Mass (Da):49,867
Last modified:November 30, 2010 - v1
Checksum:i3595D33E17F0449E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005521 Genomic DNA No translation available.
RefSeqiXP_860433.2, XM_855340.4

Genome annotation databases

EnsembliENSCAFT00000029904; ENSCAFP00000027792; ENSCAFG00000018832
GeneIDi480213
KEGGicfa:480213

Similar proteinsi

Entry informationi

Entry nameiE2QYC2_CANLF
AccessioniPrimary (citable) accession number: E2QYC2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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