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Protein
Submitted name:

ATR serine/threonine kinase

Gene

ATR

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-176187 Activation of ATR in response to replication stress
R-CFA-3371453 Regulation of HSF1-mediated heat shock response
R-CFA-5685938 HDR through Single Strand Annealing (SSA)
R-CFA-5693607 Processing of DNA double-strand break ends
R-CFA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-CFA-6783310 Fanconi Anemia Pathway
R-CFA-6804756 Regulation of TP53 Activity through Phosphorylation
R-CFA-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Submitted name:
ATR serine/threonine kinaseImported
Gene namesi
Name:ATRImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:38293 ATR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2QXA4

Expressioni

Gene expression databases

BgeeiENSCAFG00000007863 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011639

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati814 – 848HEATPROSITE-ProRule annotationAdd BLAST35
Domaini1649 – 2194FATInterPro annotationAdd BLAST546
Domaini2328 – 2650PI3K/PI4KInterPro annotationAdd BLAST323
Domaini2618 – 2650FATCInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0890 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00830000128321
InParanoidiE2QXA4
OMAiWRRFPEH
OrthoDBiEOG091G013Q
TreeFamiTF101183

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR021133 HEAT_type_2
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48452 SSF48452, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50077 HEAT_REPEAT, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E2QXA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SMGDHGLELA SMIPALRELG SASPEEYNTV VQKPRQILCQ FIDRILTDVN
60 70 80 90 100
VVALELVKKT DSQPTSVMLL DFIQHIMKSS PLMFVNVNGS QGQNEAKGSC
110 120 130 140 150
IEFSNWIITR LLRIAATPSC HLLHKKICEV ICSLLFLFKS KSPAIFGVLT
160 170 180 190 200
KELLYLCEDV ICLHRKNAVG HFVEWPVVVS RFLSQLDEHM EYLQPAPLQF
210 220 230 240 250
MNMQNLEFIE VTLLTVLIRI IAIVFFRRQE LLLWRIGCVL LEYGSSKTKS
260 270 280 290 300
LAISLLTELF ELGGLPAQPA STFFSSFLGL LKHLVEMDAD QLKLYEEPLS
310 320 330 340 350
KLIKTLFPFE AEAYRNIEPV YLNMLLENLC VMFEDGVLMR LKSDLLKAAL
360 370 380 390 400
CHLLQYFLKY VPAGYESALQ VRKVYVRNIC KVLVDVLGFQ VDAEYLLGPL
410 420 430 440 450
YAALKMESME IIEEVQCQIQ QENLSSNSDG ISAKRRRLSS SLNSSKRPPK
460 470 480 490 500
QTEEIKHVDM NKKSILWSAL KQKAESLQIF LEYNGLKNPV IATLEGITIV
510 520 530 540 550
LQLTALCTVH CSHHNMDCLE QIFSEMKEIF GLYIGLVIPH ITWMSLDFYT
560 570 580 590 600
KVLKSCRSLL ESVQKPDLEA VIDKVVKIYD ALIYIHMKTS FEDHILEDLC
610 620 630 640 650
GMLSLPWIHS HSDDGSLKLT TFATNLLALS QRISDSYSPQ AQSRCVFLLT
660 670 680 690 700
LFPRRIFLEW RTAIYSWALQ SSHEVIRASC VNGFFILLQQ QNSCNRVPKI
710 720 730 740 750
LIDKVKDDSD FVKREFASIL GQLVCTLHGM FHLTSSLTEP FSEHGYTDLF
760 770 780 790 800
CKNLKVASQH ECSSSQLKAS ICKPFLFLLR KKTPSPVKLA FIDNLYHLCK
810 820 830 840 850
HLDFREDETD VKTVLGTLLN LMEDPDKDVR VAFSGNIKHI LESLDSEDGF
860 870 880 890 900
IKELFVLRMK EAYTHAQISR NNELKDTLIL TTGDIGRAAK GDLVPFALLH
910 920 930 940 950
LLHCLLSKSA SVSGAAYTEI RALVAAKSVK LQNFFSQYKK PICQFLVESL
960 970 980 990 1000
HSSQMTALPS TPCQNAEMRK QDVAHQREMA LNTLSEIANV FDFPDLNRFL
1010 1020 1030 1040 1050
TRTLQVLLPD LAAKASPAAS ALIRTLGKQL NVNRREILIN NFKYIFSHLV
1060 1070 1080 1090 1100
CSCSKDELER ALHYLKNETE IELGSLLRQD FQGLHNELLL RIGEHYQQVF
1110 1120 1130 1140 1150
NGLSILASFA SSDDPYQGPR EITSPELMAD YLQPKLLGIL AFFNMQLLSS
1160 1170 1180 1190 1200
SVGIEDKKMA LNSLMSLMKL MGPKHVSSVR VKMMTTLRTG LRFKDDFPEL
1210 1220 1230 1240 1250
CCRAWDCFVR CLDHAYLGSL LSHVIVALLP LIHIQPEETA AIFHYLIIEN
1260 1270 1280 1290 1300
RDAVQDFLHE IYFLPDHPEL KKIKAVLQEY RKETSESTDL QTTLQLSMKA
1310 1320 1330 1340 1350
IQHENVDVRI HALTSLKETL YKNQEKLIKY ATDSETVEPV ISQLVTVLLK
1360 1370 1380 1390 1400
GCQDANSQAR LLCGECLGEL GAIDPGRLDF STTESQGKDF TFVTGVEDSS
1410 1420 1430 1440 1450
FAFGLLMELT RAYLAYADNS RAQDSAAYAI QELLSIYDCR EMQTDGPGHQ
1460 1470 1480 1490 1500
LWRRFPEHVR EILEPHLNTR YKSSQKSTDW SEVKKPIYLS KLGNNFAEWS
1510 1520 1530 1540 1550
ASWAGYLITK VRHDLASKIF TCCSIMMKHD FKVTIYLLPH ILVYVLLGCN
1560 1570 1580 1590 1600
QEDQQEVYAE IMAVLKHDDQ HTISTQDSAS DLCQLSTQTV FSMLDHLTQW
1610 1620 1630 1640 1650
ARHKFQALNA EKFPQSKSNR DKIDSVASTA DYEDYQSVTR FLDLIPQDTL
1660 1670 1680 1690 1700
AVASFRSKAY TRAVMHFESF ITEKKQNIQE HLGFLQKLYA AMHEPDGVAG
1710 1720 1730 1740 1750
VSAIRKAEPS LKEQILEHES IGLLRDATAC YDRAIQLEPD QIIHYHGVVK
1760 1770 1780 1790 1800
SMLGLGQLST VITQVNGVHA NRSEWTDELN TYRVEAAWKL SQWDLVENYL
1810 1820 1830 1840 1850
AADGKSTTWS VRLGQLLLSA KKRDTTAFYD TLKLVRAEQI VPLSAASFER
1860 1870 1880 1890 1900
GSYQRGYEYI VRLHMLCELE HSIKPLFHQS PGDSSQEDSL NWVARLEMTQ
1910 1920 1930 1940 1950
NSYRAKEPIL ALRRALLSLN KRPDYNEMVG ECWLQSARVA RKAGHHQTAY
1960 1970 1980 1990 2000
NALLNAGESR LAELYVERAK WLWSKGDVHQ ALIVLQKGVE LCFPENKTPT
2010 2020 2030 2040 2050
ESKNMLIHGR AMLLVGRFME ETANFESNAV MKKYKDVTLF LPEWEDGHFY
2060 2070 2080 2090 2100
LAKYYDKLMP MVTDNKMEKQ GDLIRYIVLH FGRSLQYGNQ FIYQSMPRML
2110 2120 2130 2140 2150
SLWLDFGAKA YEWEKAGRSD RVQMRNDLAK INKVITEHTN HLAPYQFLTA
2160 2170 2180 2190 2200
FSQLISRICH SHDEVFVVLM EIIAKVFLAY PQQAMWMMTA VSKSSYPMRV
2210 2220 2230 2240 2250
NRCKEILNKA IHMKKSLEKF IGDATRLTDK LLELCNKPVD GSSSTLSMST
2260 2270 2280 2290 2300
HFKMLKKLVE EPTFSEILIP LQSVMIPTLP SIPGAHANHE PFPGHWAYIA
2310 2320 2330 2340 2350
SFDDMVEILA SLQKPKKISL KGSDGKFYIM MCKPKDDLRK DCRLMEFNSL
2360 2370 2380 2390 2400
INKCLRKDAE SRRRELHIRT YAVIPLNDEC GIIEWVNNTA GLRPILTKLY
2410 2420 2430 2440 2450
KEKGVYMTGK ELRQCMLPKA AALSEKLKVF REFLLPRHPP VFHEWFLRTF
2460 2470 2480 2490 2500
PDPTSWYSSR SAYCRSTAVM SMVGYILGLG DRHGENILFD SLTGECVHVD
2510 2520 2530 2540 2550
FNCLFNKGET FEVPEIVPFR LTHNMVNGMG PMGTEGLFRR ACEVTMRLMR
2560 2570 2580 2590 2600
DQREPLMSVL KTFLHDPLVE WSKPVKGHSK APLNETGEVV NEKAKTHVLD
2610 2620 2630 2640 2650
IEQRLQGVIK TRNRVTGLPL SIEGHVHYLI QEATDENLLC QMYLGWTPYM
Length:2,650
Mass (Da):302,233
Last modified:October 31, 2012 - v2
Checksum:iD5C414DCADC869C6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9P2H2J9P2H2_CANLF
ATR serine/threonine kinase
ATR
2,640Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013647 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000012571; ENSCAFP00000011639; ENSCAFG00000007863

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013647 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011639

Proteomic databases

PaxDbiE2QXA4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000012571; ENSCAFP00000011639; ENSCAFG00000007863

Organism-specific databases

VGNCiVGNC:38293 ATR

Phylogenomic databases

eggNOGiKOG0890 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00830000128321
InParanoidiE2QXA4
OMAiWRRFPEH
OrthoDBiEOG091G013Q
TreeFamiTF101183

Enzyme and pathway databases

ReactomeiR-CFA-176187 Activation of ATR in response to replication stress
R-CFA-3371453 Regulation of HSF1-mediated heat shock response
R-CFA-5685938 HDR through Single Strand Annealing (SSA)
R-CFA-5693607 Processing of DNA double-strand break ends
R-CFA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-CFA-6783310 Fanconi Anemia Pathway
R-CFA-6804756 Regulation of TP53 Activity through Phosphorylation
R-CFA-69473 G2/M DNA damage checkpoint

Gene expression databases

BgeeiENSCAFG00000007863 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR021133 HEAT_type_2
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48452 SSF48452, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50077 HEAT_REPEAT, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2QXA4_CANLF
AccessioniPrimary (citable) accession number: E2QXA4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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