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Protein
Submitted name:

Interleukin 1 receptor associated kinase 1

Gene

IRAK1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-1257604 PIP3 activates AKT signaling
R-CFA-168638 NOD1/2 Signaling Pathway
R-CFA-209543 p75NTR recruits signalling complexes
R-CFA-209560 NF-kB is activated and signals survival
R-CFA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-CFA-450302 activated TAK1 mediates p38 MAPK activation
R-CFA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-CFA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CFA-9020702 Interleukin-1 signaling
R-CFA-937039 IRAK1 recruits IKK complex
R-CFA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-CFA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-CFA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-CFA-975155 MyD88 dependent cascade initiated on endosome

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 1 receptor associated kinase 1Imported
Gene namesi
Name:IRAK1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:42087 IRAK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2QX24

Expressioni

Gene expression databases

BgeeiENSCAFG00000019436

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000028744

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 522Protein kinaseInterPro annotationAdd BLAST310

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
InParanoidiE2QX24
KOiK04730
OMAiGFYCLVY
OrthoDBiEOG091G0YKT
TreeFamiTF328924

Family and domain databases

CDDicd08794 Death_IRAK1, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR035533 Death_IRAK1
IPR035536 IRAK1
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24419:SF1 PTHR24419:SF1, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E2QX24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPGPGDP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV
60 70 80 90 100
RDQTELRLCE RSGQRTASVL WPWINRNARV ADLVSILTHL QLLRARDIIT
110 120 130 140 150
AWHPPAPLLP PSTSAPRPSS PPAPCEADVP RPRKLPTASA STLPSPAFPG
160 170 180 190 200
SQTHSGAELG PVHSPGILQP PPPRPAPSST KPSAESPASL LQGAHPSPFC
210 220 230 240 250
WPLSEISQGT HNFSDKLKIG EGGFGCVYRA VMRNTLYAVK RLKEGADLEW
260 270 280 290 300
TTVKQSFLTE VEQLSRFRHP NIVDFAGYCA ESGFYCLVYG FLPNGSLEDR
310 320 330 340 350
LHFQTEACAP LSWPQRLNIL LGTARAIQFL HQDSPSLIHG DIKSSNVLLD
360 370 380 390 400
DRLMPKLGDF GLARLSRFAG ANPGQSSTVA RTRTVRGTLA YLPEEYVKTG
410 420 430 440 450
RLAVDTDTFS FGVVVLETLA GQRAVRTQGA KTKYLKDLVE EEAEEAGVTL
460 470 480 490 500
RSTQSTLQAG LATDAWAAPI ASQICKKHLD PRPGPCPPEL GLVLGQLACC
510 520 530 540 550
CLHRRAKRRP PMTQVYERLE KLQVAVAVAG AEAAHHGPPS PQENSYVSVP
560 570 580 590 600
SSGASPRQPL AAPSGAPAQA TEWLQKGPNQ PVESDESVSG LSAALCSWHM
610 620 630 640 650
SPSCPPGLAL PGSPAQGATL GAAAPLGQAG SARGGASQEP SWGGGPGPQL
660 670 680 690 700
TAVEGSLLSS SASSQPPQIV INPARQKMVQ KLALYEDGVL DSLQLLSSSS
710 720
LPDLGGEHQH RPRPEESDEF QS
Length:722
Mass (Da):77,014
Last modified:October 31, 2012 - v2
Checksum:i8FD838D54161685B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03027091 Genomic DNA No translation available.
RefSeqiXP_549367.2, XM_549367.5

Genome annotation databases

EnsembliENSCAFT00000030910; ENSCAFP00000028744; ENSCAFG00000019436
GeneIDi492247
KEGGicfa:492247

Similar proteinsi

Entry informationi

Entry nameiE2QX24_CANLF
AccessioniPrimary (citable) accession number: E2QX24
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: May 23, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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