UniProtKB - E2QRB3 (E2QRB3_HUMAN)
Protein
Pyrroline-5-carboxylate reductase
Gene
PYCR1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
: L-proline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (P5CR2), Pyrroline-5-carboxylate reductase (PIG45), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR3), Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1), Pyrroline-5-carboxylate reductase 2 (PYCR2), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase (PYCR3), Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase 3 (PYCR3), Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase (PYCRL), Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase (PYCR1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- pyrroline-5-carboxylate reductase activity Source: UniProtKB-EC
GO - Biological processi
- L-proline biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Biological process | Amino-acid biosynthesis, Proline biosynthesisARBA annotation |
Ligand | NADPARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00361 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PYCR1Imported ORF Names:hCG_38803Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183010.16 |
HGNCi | HGNC:9721, PYCR1 |
PTM / Processingi
Proteomic databases
MaxQBi | E2QRB3 |
PRIDEi | E2QRB3 |
ProteomicsDBi | 15223 |
PTM databases
SwissPalmi | E2QRB3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183010, Expressed in pancreas and 201 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 98 | F420_oxidoredInterPro annotationAdd BLAST | 96 | |
Domaini | 181 – 237 | P5CR_dimerInterPro annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 263 – 288 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the pyrroline-5-carboxylate reductase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00950000183044 |
Family and domain databases
HAMAPi | MF_01925, P5C_reductase, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF14748, P5CR_dimer, 1 hit |
PIRSFi | PIRSF000193, Pyrrol-5-carb_rd, 2 hits |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00521, P5CR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
E2QRB3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV
60 70 80 90 100
KLTPHNKETV QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT
110 120 130 140 150
ISSIEKKLSA FRPAPRVIRC MTNTPVVVRE GATVYATGTH AQVEDGRLME
160 170 180 190 200
QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY GAAKMLLHSE QHPGQLKDNV
210 220 230 240 250
SSPGGATIHA LHVLESGGFR SLLINAVEAS CIRTRELQSM ADQEQVSPAA
260 270 280
IKKTILDKVK LDSPAGTALS PSGHTKLLPR SLAPAGKD
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP32322 | P5CR1_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 | 319 | Annotation score: | ||
J3QKT4 | J3QKT4_HUMAN | Pyrroline-5-carboxylate reductase | PYCR1 | 242 | Annotation score: | ||
J3KQ22 | J3KQ22_HUMAN | Pyrroline-5-carboxylate reductase | PYCR1 | 253 | Annotation score: | ||
J3QL24 | J3QL24_HUMAN | Pyrroline-5-carboxylate reductase | PYCR1 | 225 | Annotation score: | ||
J3QL32 | J3QL32_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 hCG_38803 | 217 | Annotation score: | ||
J3QR88 | J3QR88_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 | 132 | Annotation score: | ||
J3KSA9 | J3KSA9_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 | 109 | Annotation score: | ||
J3KTA8 | J3KTA8_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 | 84 | Annotation score: | ||
J3QLK9 | J3QLK9_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 | 165 | Annotation score: | ||
J3QRZ0 | J3QRZ0_HUMAN | Pyrroline-5-carboxylate reductase 1... | PYCR1 | 115 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145207 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89719.1 |
RefSeqi | NP_001269208.1, NM_001282279.1 |
Genome annotation databases
Ensembli | ENST00000403172; ENSP00000385483; ENSG00000183010 |
GeneIDi | 5831 |
UCSCi | uc002kcu.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145207 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89719.1 |
RefSeqi | NP_001269208.1, NM_001282279.1 |
3D structure databases
SMRi | E2QRB3 |
ModBasei | Search... |
PTM databases
SwissPalmi | E2QRB3 |
Proteomic databases
MaxQBi | E2QRB3 |
PRIDEi | E2QRB3 |
ProteomicsDBi | 15223 |
Protocols and materials databases
Antibodypediai | 32938, 225 antibodies |
Genome annotation databases
Ensembli | ENST00000403172; ENSP00000385483; ENSG00000183010 |
GeneIDi | 5831 |
UCSCi | uc002kcu.3, human |
Organism-specific databases
CTDi | 5831 |
EuPathDBi | HostDB:ENSG00000183010.16 |
HGNCi | HGNC:9721, PYCR1 |
OpenTargetsi | ENSG00000183010 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183044 |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00361 |
Miscellaneous databases
BioGRID-ORCSi | 5831, 14 hits in 843 CRISPR screens |
ChiTaRSi | PYCR1, human |
GenomeRNAii | 5831 |
Gene expression databases
Bgeei | ENSG00000183010, Expressed in pancreas and 201 other tissues |
Family and domain databases
HAMAPi | MF_01925, P5C_reductase, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF14748, P5CR_dimer, 1 hit |
PIRSFi | PIRSF000193, Pyrrol-5-carb_rd, 2 hits |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00521, P5CR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E2QRB3_HUMAN | |
Accessioni | E2QRB3Primary (citable) accession number: E2QRB3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2010 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |