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UniProtKB - E2QCY2 (E2QCY2_DROME)
Protein
Arachidonate--CoA ligase
Gene
ACSL1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateARBA annotationEC:6.2.1.15ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphateARBA annotationEC:6.2.1.3ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
GO - Molecular functioni
- long-chain fatty acid-CoA ligase activity Source: FlyBase
GO - Biological processi
- long-chain fatty acid metabolic process Source: FlyBase
Keywordsi
Molecular function | LigaseImported |
Biological process | Fatty acid metabolismARBA annotation, Lipid metabolism |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACSL1Imported Synonyms:CG3961-RDImported, Dmel\CG3961Imported ORF Names:CG3961Imported, Dmel_CG3961Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0036821, CG3961 |
VEuPathDBi | VectorBase:FBgn0036821 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Other locations
- membrane Source: GO_Central
Expressioni
Gene expression databases
Bgeei | FBgn0036821, Expressed in material anatomical entity and 45 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 520 | AMP-bindingInterPro annotationAdd BLAST | 443 | |
Domaini | 529 – 571 | AMP-binding_CInterPro annotationAdd BLAST | 43 |
Phylogenomic databases
GeneTreei | ENSGT00940000156651 |
HOGENOMi | CLU_000022_45_4_1 |
OMAi | IAKCPIV |
Family and domain databases
CDDi | cd05927, LC-FACS_euk, 1 hit |
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045311, LC-FACS_euk |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E2QCY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSCCGQITSI RVPIELSNQS DVLKGPEQIH VSKFYKESKN GKFVSYITEN
60 70 80 90 100
VRTLYQTFRE GAYASNNGPC LGWRETLTSP YQWINYDEAL LRAKNFGAGM
110 120 130 140 150
LALGARPKQL IGIYSQNRPE WILYEQGCYS FSLVVVPLYD TLGPDACAFI
160 170 180 190 200
IRQTDMQVVI VEDDGKAAML LEKAPRSLKI IVAIKPIRQT TLERARSRGI
210 220 230 240 250
QIFSFIDVEK LGAKGNHPEV PPTAEDLCTV CYTSGTTGNP KGVMLTHGNV
260 270 280 290 300
VAGVCSVILQ MGDHRIRAGD VMVSFLPLAH MFERCCENGM YYVGGCVGFY
310 320 330 340 350
SGDIKELTND LKMLKPTVMP AVPRLLNRVY DKIQNDISAS GLKRGLFNMA
360 370 380 390 400
MRAKEKEIAR GVLRRNGCWD KLVFKKVHQA FGGNLRLMVV GSAPLAGNVL
410 420 430 440 450
TFMRCALGCL VLEGYGQTEC TGAITLTVQG DHVPNHVGPP VSCNAVKLVD
460 470 480 490 500
VPEMEYFANQ NTGEVCVRGS NVFHGYYKDP EKTAEAIDSE GWHHTGDVGM
510 520 530 540 550
WLPNGTLRII DRRKHIFKLS QGEYIVPEKI ENIYTLSQYV NQVYVYGESL
560 570 580 590 600
KSCIIAVVVP DTDVLKQWAT ENNVRGTLSV LCNNKNVKEL IMNDMLNWGK
610 620 630 640 650
QSGLKSFEQV KDIYLHPDPF SVQNGLLTPT FKAKRPQLKS YFKPQLEDMY
KHLD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9VVT8 | Q9VVT8_DROME | Arachidonate--CoA ligase | ACSL1 CG3961-RA, Dmel\CG3961, CG3961, Dmel_CG3961 | 704 | Annotation score: | ||
M9PCX4 | M9PCX4_DROME | Arachidonate--CoA ligase | ACSL1 Dmel\CG3961, CG3961, Dmel_CG3961 | 666 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAN11673.2 BT132918 mRNA Translation: AEW12890.1 |
RefSeqi | NP_730370.2, NM_168782.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0302322; FBpp0291528; FBgn0036821 |
GeneIDi | 40056 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAN11673.2 BT132918 mRNA Translation: AEW12890.1 |
RefSeqi | NP_730370.2, NM_168782.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 40056 |
Genome annotation databases
EnsemblMetazoai | FBtr0302322; FBpp0291528; FBgn0036821 |
GeneIDi | 40056 |
Organism-specific databases
FlyBasei | FBgn0036821, CG3961 |
VEuPathDBi | VectorBase:FBgn0036821 |
Phylogenomic databases
GeneTreei | ENSGT00940000156651 |
HOGENOMi | CLU_000022_45_4_1 |
OMAi | IAKCPIV |
Miscellaneous databases
BioGRID-ORCSi | 40056, 0 hits in 3 CRISPR screens |
GenomeRNAii | 40056 |
Gene expression databases
Bgeei | FBgn0036821, Expressed in material anatomical entity and 45 other tissues |
Family and domain databases
CDDi | cd05927, LC-FACS_euk, 1 hit |
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045311, LC-FACS_euk |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E2QCY2_DROME | |
Accessioni | E2QCY2Primary (citable) accession number: E2QCY2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |