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UniProtKB - E2QCR4 (E2QCR4_DROME)

Entry version 86 (19 Jan 2022)
Sequence version 1 (30 Nov 2010)
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Protein
Submitted name:

Bicaudal C, isoform B

Gene

BicC

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Bicaudal C, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BicCImported
Synonyms:BG:DS00913.2Imported, Bic-CImported, BICCImported, bicCImported, br34Imported, Dmel\CG4824Imported, l(2)br34Imported
ORF Names:CG4824Imported, Dmel_CG4824Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0000182, BicC

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0000182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0000182, Expressed in embryo and 17 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E2QCR4, DM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E2QCR4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini805 – 868SAMInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni559 – 660DisorderedSequence analysisAdd BLAST102
Regioni751 – 772DisorderedSequence analysisAdd BLAST22
Regioni874 – 905DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi586 – 641Polar residuesSequence analysisAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BicC family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008040_0_0_1

Database for complete collections of gene phylogenies

More...PhylomeDBi		E2QCR4

Family and domain databases

Conserved Domains Database

More...CDDi		cd09520, SAM_BICC1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037974, BICC1_SAM_dom
IPR004087, KH_dom
IPR004088, KH_dom_type_1
IPR036612, KH_dom_type_1_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00013, KH_1, 2 hits
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00322, KH, 2 hits
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit
SSF54791, SSF54791, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E2QCR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSCASFNKL MYPSAADVAK PPMVGLEVEA GSIGSLSSLH ALPSTTSVGS 
        60         70         80         90        100
GAPSETQSEI SSVDSDWSDI RAIAMKLGVQ NPDDLHTERF KVDRQKLEQL 
       110        120        130        140        150
IKAESSIEGM NGAEYFFHDI MNTTDTYVSW PCRLKIGAKS KKDPHVRIVG 
       160        170        180        190        200
KVDQVQRAKE RILSSLDSRG TRVIMKMDVS YTDHSYIIGR GGNNIKRIMD 
       210        220        230        240        250
DTHTHIHFPD SNRSNPTEKS NQVSLCGSLE GVERARALVR LSTPLLISFE 
       260        270        280        290        300
MPVMGPNKPQ PDHETPYIKM IETKFNVQVI FSTRPKLHTS LVLVKGSEKE 
       310        320        330        340        350
SAQVRDATQL LINFACESIA SQILVNVQME ISPQHHEIVK GKNNVNLLSI 
       360        370        380        390        400
MERTQTKIIF PDLSDMNVKP LKKSQVTISG RIDDVYLARQ QLLGNLPVAL 
       410        420        430        440        450
IFDFPDNHND ASEIMSLNTK YGVYITLRQK QRQSTLAIVV KGVEKFIDKI 
       460        470        480        490        500
YEARQEILRL ATPFVKPEIP DYYFMPKDKD LNLAYRTQLT ALLAGYVDSP 
       510        520        530        540        550
KTPSLLPPSL AGQLTPYANN NHLLLNANGL ATPTGVCAPT QKYMQLHNSF 
       560        570        580        590        600
QQAQNRSMVA GGQSNNGNYL QVPGAVAPPL KPPTVSPRNS CSQNTSGYQS 
       610        620        630        640        650
FSSSTTSLEQ SYPPYAQLPG TVSSTSSSTA GSQNRAHYSP DSTYGSEGGG 
       660        670        680        690        700
VGGGGGGGAR LGRRLSDGVL LGLSNSNGGG GNSGGAHLLP GSAESYRSLH 
       710        720        730        740        750
YDLGGNKHSG HRAFDFDMKR ALGYKAMERT PVAGELRTPT TAWMGMGLSS 
       760        770        780        790        800
TSPAPAPLEN GENGAAGGGA SSGWRLPPGL GSPYGLSATT GLLDATPVNR 
       810        820        830        840        850
RMQLAKHKDI QTLLTSLGLE HYIKIFVLNE IDLEVFTTLT EENLMELGIA 
       860        870        880        890        900
AFGARKKLLT AIHTLLANEA ACSTMPSSSS SQNSSSPRFS GSAAPGAERR 

PSNQW
Length:905
Mass (Da):97,849
Last modified:November 30, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22FC1CD4BB231603
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q24009BICC_DROME
Protein bicaudal C
BicC CG4824
905Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53499.1

NCBI Reference Sequences

More...RefSeqi		NP_476865.1, NM_057517.3
NP_723948.1, NM_165144.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0080803; FBpp0080361; FBgn0000182
FBtr0080804; FBpp0080362; FBgn0000182

Database of genes from NCBI RefSeq genomes

More...GeneIDi		34946

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG4824

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53499.1
RefSeqiNP_476865.1, NM_057517.3
NP_723948.1, NM_165144.2

3D structure databases

SMRiE2QCR4
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080803; FBpp0080361; FBgn0000182
FBtr0080804; FBpp0080362; FBgn0000182
GeneIDi34946
KEGGidme:Dmel_CG4824

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		34946
FlyBaseiFBgn0000182, BicC
VEuPathDBiVectorBase:FBgn0000182

Phylogenomic databases

HOGENOMiCLU_008040_0_0_1
PhylomeDBiE2QCR4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		34946, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cul3, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		34946

Gene expression databases

BgeeiFBgn0000182, Expressed in embryo and 17 other tissues
GenevisibleiE2QCR4, DM

Family and domain databases

CDDicd09520, SAM_BICC1, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR037974, BICC1_SAM_dom
IPR004087, KH_dom
IPR004088, KH_dom_type_1
IPR036612, KH_dom_type_1_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
PfamiView protein in Pfam
PF00013, KH_1, 2 hits
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM00322, KH, 2 hits
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF54791, SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2QCR4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2QCR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: January 19, 2022
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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