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Protein
Submitted name:

DAPK1

Gene

DAPK1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
DAPK1Imported
Submitted name:
Death associated protein kinase 1Imported
Gene namesi
Name:DAPK1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:39770 DAPK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSCAFG00000001316 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001889

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 275Protein kinaseInterPro annotationAdd BLAST263
Domaini371 – 662ANK_REP_REGIONInterPro annotationAdd BLAST292
Repeati378 – 410ANKPROSITE-ProRule annotationAdd BLAST33
Repeati444 – 476ANKPROSITE-ProRule annotationAdd BLAST33
Repeati477 – 509ANKPROSITE-ProRule annotationAdd BLAST33
Repeati510 – 542ANKPROSITE-ProRule annotationAdd BLAST33
Repeati543 – 575ANKPROSITE-ProRule annotationAdd BLAST33
Repeati576 – 608ANKPROSITE-ProRule annotationAdd BLAST33
Repeati609 – 641ANKPROSITE-ProRule annotationAdd BLAST33
Domaini681 – 955RocInterPro annotationAdd BLAST275
Domaini1321 – 1396DeathInterPro annotationAdd BLAST76

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118877
KOiK08803
OMAiCQMEVIK
OrthoDBiEOG091G0J2O
TreeFamiTF314166

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR020676 DAPK1
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR011009 Kinase-like_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR020859 ROC_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR44619 PTHR44619, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 9 hits
SM00005 DEATH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 7 hits
PS50017 DEATH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51424 ROC, 1 hit

Sequencei

Sequence statusi: Complete.

E2JE41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK
60 70 80 90 100
SSRRGVSRED IEREVSILKE IQHPNVITLH EVYENKTDVI LILELVAGGE
110 120 130 140 150
LFDFLAEKES LTEEEATEFL KQILNGVYYL HSLQIAHFDL KPENIMLLDR
160 170 180 190 200
NVPKPRIKII DFGLAHKIDF GNEFKNIFGT PEFVAPEIVN YEPLGLEADM
210 220 230 240 250
WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEEEY FSNTSALAKD
260 270 280 290 300
FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRKASA VNMEKFKKFA
310 320 330 340 350
ARKKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH
360 370 380 390 400
AINDDNVPGL QHLLGSLSNY DVNQPNKHGT PPLLIAAGCG NIQILQLLIK
410 420 430 440 450
RGSRIDVQDK GGSNAIYWAS RHGHVDTLKF LNENKCPLDV KDKSGETALH
460 470 480 490 500
VAARYGHADV VQLLCSFGSN PNFQDKEEET PLHCAAWHGY YSVAKALCEA
510 520 530 540 550
GCNVNSKNRE GETPLLTASA RGYHDIVECL SEHGADLNAS DKDGHIALHL
560 570 580 590 600
AVRRCQMEVI QTLISQGCSV DFQDRHGNTP LHVACKDGNV PIVVALCEAS
610 620 630 640 650
CNLDISNKYG RTPLHLAANN GILDVVRYLC LAGANVEALT SDGKTAEELA
660 670 680 690 700
KSEQHEHVAG LLARLRKDAH RGLFIQQLRP TQNLQSRIKL KLFGHSGSGK
710 720 730 740 750
TTLVESLKCG LLRSFFRRRR PRLSSTNSTR FPPSPLASKP AVSVSISNLY
760 770 780 790 800
PGCEHVSVRS RSMMFEPGLT RGTLGVLVAP PPHLHCATDD QSTKAIDIQN
810 820 830 840 850
AYLNGVGDFS VWEFSGNPVY FCCYDYFAAN DPTSIHIIVF SLEEPYEIQL
860 870 880 890 900
NQVIFWLNFL KSLVPVEEPI AFGGKLKNPL HVVLVATHAD IMNVPRPAGG
910 920 930 940 950
EFGYDKDTSL LKEIKNRFGN DLHISNKLFV LDAGASGSKD MKVLRSHLQD
960 970 980 990 1000
IRSQIVSVCP PMTHLCEKII STLPSWRKLN GPNQLMSLQQ FVYDVQDQLN
1010 1020 1030 1040 1050
PLAREGDLRR IAQQLHSAGE INIMQSETVQ DVLLLDPRWL CTNVLGKLLS
1060 1070 1080 1090 1100
VETPRALHHY RGRYTVEDVQ RLVPDSDVEE LLQILDAMDI CARDLSSGTM
1110 1120 1130 1140 1150
VDIPALIKTD NLHRSWTDEE DEGRVYGGVR IVPVEYLTPF PCGIFHKVQV
1160 1170 1180 1190 1200
NLCRWIHQQS AEGDADIRLW VNGCKIANRG AELLVLLVNH GQGIEVQVRG
1210 1220 1230 1240 1250
LETEKIKCCL LLDSVCSTME NVMATTLPGL LTVKHYLSPQ QLREHHEPVM
1260 1270 1280 1290 1300
IYQPRDFFRA QTLKETSLTN TMGGYKESFS SIMCFGCHDV YSQASLGMDI
1310 1320 1330 1340 1350
HASDLNLLTR RKLCRLLDPP DPMGKDWCLL AMNLGLPDLV AKYNTNNGAP
1360 1370 1380 1390 1400
KEFLPSPVHA LLREWTSYPE STVGILMSKL RELGRRDAAD FLLKASSVFK
1410 1420 1430
INLDGNGQET YDSSCNSGTS YNSISSVVSR
Length:1,430
Mass (Da):159,867
Last modified:November 30, 2010 - v1
Checksum:i05100C84871BACF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000500 Genomic DNA No translation available.
HQ189123 mRNA Translation: ADN92461.1
RefSeqiNP_001184086.1, NM_001197157.1
XP_005615813.1, XM_005615756.2
XP_005615814.1, XM_005615757.2
XP_005615815.1, XM_005615758.2
XP_005615816.1, XM_005615759.1
UniGeneiCfa.35381

Genome annotation databases

EnsembliENSCAFT00000002041; ENSCAFP00000001889; ENSCAFG00000001316
GeneIDi484142
KEGGicfa:484142

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000500 Genomic DNA No translation available.
HQ189123 mRNA Translation: ADN92461.1
RefSeqiNP_001184086.1, NM_001197157.1
XP_005615813.1, XM_005615756.2
XP_005615814.1, XM_005615757.2
XP_005615815.1, XM_005615758.2
XP_005615816.1, XM_005615759.1
UniGeneiCfa.35381

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001889

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000002041; ENSCAFP00000001889; ENSCAFG00000001316
GeneIDi484142
KEGGicfa:484142

Organism-specific databases

CTDi1612
VGNCiVGNC:39770 DAPK1

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118877
KOiK08803
OMAiCQMEVIK
OrthoDBiEOG091G0J2O
TreeFamiTF314166

Gene expression databases

BgeeiENSCAFG00000001316 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR020676 DAPK1
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR011009 Kinase-like_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR020859 ROC_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR44619 PTHR44619, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 9 hits
SM00005 DEATH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 7 hits
PS50017 DEATH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51424 ROC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2JE41_CANLF
AccessioniPrimary (citable) accession number: E2JE41
Secondary accession number(s): F1PML8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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