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Protein
Submitted name:

Interferon regulatory factor 3a

Gene

IRF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Enzyme and pathway databases

SignaLinkiE2GIM5

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 3aImported
Gene namesi
Name:IRF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiE2GIM5
PRIDEiE2GIM5

Expressioni

Gene expression databases

GenevisibleiE2GIM5 HS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76IRF tryptophan pentad repeatInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXD8 Eukaryota
ENOG410YA4B LUCA

Family and domain databases

Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS51507 IRF_2, 1 hit

Sequencei

Sequence statusi: Complete.

E2GIM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGRKQGWSC RLTGIKPGKP AWAEATGAYV PGRDKPDLPT WKRNFRSALN
60 70 80 90 100
RKEGLRLAED RSKDPHDPHK IYEFVNSGVG DFSQPDTSPD TNGGGSTSDT
110 120 130 140 150
QEDILDELLG NMVLAPLPDP GPPSLAVAPE PCPQPLRSPS LDNPTPFPNL
160 170 180 190 200
GPSENPLKRL LVPGEEWEFE VTAFYRGRQV FQQTISCPEG LRLVGSEVGD
210 220 230 240 250
RTLPGWPVTL PDPGMSLTDR GVMSYVRHVP SCLGGGLALW RAGQWLWAQR
260 270 280 290 300
LGHCHTYWAV SEELLPNSGH GPDGEVPKDK EGGVFDLGPF IVDLITFTEG
310 320 330 340 350
SGRSPRYALW FCVGESWPQD QPWTKRLVMV KVVPTCLRAL VEMARVGGAS
360 370 380 390
SLENTVDLHI SNSHPLSLTS DQYKAYLQDL VEGMDFQGPG ET
Length:392
Mass (Da):42,970
Last modified:November 30, 2010 - v1
Checksum:i9A942E0AE51F388C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM357932 mRNA Translation: ADN86147.1
RefSeqiNP_001184052.1, NM_001197123.1
UniGeneiHs.289052
Hs.731922
Hs.75254

Genome annotation databases

GeneIDi3661

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM357932 mRNA Translation: ADN86147.1
RefSeqiNP_001184052.1, NM_001197123.1
UniGeneiHs.289052
Hs.731922
Hs.75254

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE2GIM5
PRIDEiE2GIM5

Protocols and materials databases

DNASUi3661
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3661

Organism-specific databases

CTDi3661

Phylogenomic databases

eggNOGiENOG410IXD8 Eukaryota
ENOG410YA4B LUCA

Enzyme and pathway databases

SignaLinkiE2GIM5

Miscellaneous databases

ChiTaRSiIRF3 human
GenomeRNAii3661

Gene expression databases

GenevisibleiE2GIM5 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS51507 IRF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2GIM5_HUMAN
AccessioniPrimary (citable) accession number: E2GIM5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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