UniProtKB - E2DRY6 (E2DRY6_HUMAN)
Protein
2-phospho-D-glycerate hydro-lyase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:4.2.1.11ARBA annotation
Cofactori
Mg2+ARBA annotation
: glycolysis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.ARBA annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-278), Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-162eP), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- Phosphoglycerate kinase, Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase (HEL-S-68p), Phosphoglycerate kinase (HEL-S-272), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase
- no protein annotated in this organism
- Beta-enolase (ENO3), Alpha-enolase (ENO1), 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase (ENO4), 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase (HEL-S-17), 2-phospho-D-glycerate hydro-lyase (ENO4), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO2), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO2), Enolase 4 (ENO4), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO2), 2-phospho-D-glycerate hydro-lyase (ENO2), 2-phospho-D-glycerate hydro-lyase (EDARADD), Gamma-enolase (ENO2)
- Pyruvate kinase, Pyruvate kinase PKLR (PKLR), Pyruvate kinase, Pyruvate kinase, Pyruvate kinase PKM (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKLR), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (HEL-S-30), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (PKLR), Pyruvate kinase (PKLR), Pyruvate kinase (PKM2), Pyruvate kinase, Pyruvate kinase (PKM)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- phosphopyruvate hydratase activity Source: UniProtKB-EC
GO - Biological processi
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | LyaseARBA annotation |
Biological process | GlycolysisARBA annotation |
Ligand | MagnesiumARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00187 |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytosol
- phosphopyruvate hydratase complex Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 38 | Enolase_NInterPro annotationAdd BLAST | 38 | |
Domaini | 46 – 335 | Enolase_CInterPro annotationAdd BLAST | 290 |
Sequence similaritiesi
Belongs to the enolase family.ARBA annotation
Family and domain databases
CDDi | cd03313, enolase, 1 hit |
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
InterProi | View protein in InterPro IPR000941, Enolase IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR020810, Enolase_C IPR020809, Enolase_CS IPR020811, Enolase_N |
PANTHERi | PTHR11902, PTHR11902, 1 hit |
Pfami | View protein in Pfam PF00113, Enolase_C, 1 hit PF03952, Enolase_N, 1 hit |
PRINTSi | PR00148, ENOLASE |
SFLDi | SFLDG00178, enolase, 1 hit |
SMARTi | View protein in SMART SM01192, Enolase_C, 1 hit SM01193, Enolase_N, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
PROSITEi | View protein in PROSITE PS00164, ENOLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
E2DRY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGTENKSKF GANAILGVSL AVCKAGAVEK GVPLYRHIAD LAGNSEVILP
60 70 80 90 100
VPAFNVINGG SHAGNKLAMQ EFMILPVGAA NFREAMRIGA EVYHNLKNVI
110 120 130 140 150
KEKYGKDATN VGDEGGFAPN ILENKEGLEL LKTAIGKAGY TDKVVIGMDV
160 170 180 190 200
AASEFFRSGK YDLDFKSPDD PSRYISPDQL ADLYKSFIKD YPVVSIEDPF
210 220 230 240 250
DQDDWGAWQK FTASAGIQVV GDDLTVTNPK RIAKAVNEKS CNCLLLKVNQ
260 270 280 290 300
IGSVTESLQA CKLAQANGWG VMVSHRSGET EDTFIADLVV GLCTGQIKTG
310 320 330
APCRSERLAK YNQLLRIEEE LGSKAKFAGR NFRNPLAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU170215 mRNA Translation: ADK47995.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU170215 mRNA Translation: ADK47995.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E2DRY6 |
PRIDEi | E2DRY6 |
Protocols and materials databases
DNASUi | 2023 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00187 |
Miscellaneous databases
BioGRID-ORCSi | 2023, 376 hits in 860 CRISPR screens |
GenomeRNAii | 2023 |
Gene expression databases
Genevisiblei | E2DRY6, HS |
Family and domain databases
CDDi | cd03313, enolase, 1 hit |
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
InterProi | View protein in InterPro IPR000941, Enolase IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR020810, Enolase_C IPR020809, Enolase_CS IPR020811, Enolase_N |
PANTHERi | PTHR11902, PTHR11902, 1 hit |
Pfami | View protein in Pfam PF00113, Enolase_C, 1 hit PF03952, Enolase_N, 1 hit |
PRINTSi | PR00148, ENOLASE |
SFLDi | SFLDG00178, enolase, 1 hit |
SMARTi | View protein in SMART SM01192, Enolase_C, 1 hit SM01193, Enolase_N, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
PROSITEi | View protein in PROSITE PS00164, ENOLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E2DRY6_HUMAN | |
Accessioni | E2DRY6Primary (citable) accession number: E2DRY6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |