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Protein

Alpha-conotoxin Vc1.2

Gene
N/A
Organism
Conus victoriae (Queen Victoria cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Shows inhibition on alpha-3-beta-2/CHRNA3-CHRNB2 (IC50=75 nM), alpha-7/CHRNA7 (IC50=637 nM) and alpha-9-alpha-10/CHRNA9-CHRNA10 nAChRs (IC50=1000 nM). In addition, it also shows inhibition on high-voltage activated (HVA) calcium channels currents (30% at 100 nM) that are mediated by GABA(B) receptors (GABBR1 and GABBR2).1 Publication

Miscellaneous

Does not show activity on alpha-3/beta-4 (CHRNA3/CHRNB4), alpha-4/beta-2 (CHRNA4/CHRNB2) and alpha-4/beta-4 (CHRNA4/CHRNB4) acetylcholine receptors.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin Vc1.2
OrganismiConus victoriae (Queen Victoria cone)
Taxonomic identifieri319920 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusCylinder

Organism-specific databases

ConoServeri4199 Vc1.2 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000042515919 – 43By similarityAdd BLAST25
PeptideiPRO_000042516045 – 60Alpha-conotoxin Vc1.2Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 52By similarity
Disulfide bondi47 ↔ 60By similarity
Modified residuei60Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Developmental stagei

Mostly expressed in embryos. Also slightly expressed in adults, but the toxin is not found in adult venom.1 Publication

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E2DIH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV FFTSDRASDG RKAAASDLIT LTIKGCCSNP
60
ACMVNNPQIC GRRR
Length:64
Mass (Da):6,988
Last modified:November 30, 2010 - v1
Checksum:i1B53A5F883DD2B56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU046308 mRNA Translation: ADC80509.1

Similar proteinsi

Cross-referencesi

Web resourcesi

Biological Magnetic Resonance Data Bank

Alpha-conotoxin Vc1.2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU046308 mRNA Translation: ADC80509.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri4199 Vc1.2 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA12_CONVC
AccessioniPrimary (citable) accession number: E2DIH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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