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Entry version 56 (17 Jun 2020)
Sequence version 1 (30 Nov 2010)
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Protein
Submitted name:

Regulator of G-protein signaling 12

Gene

EAI_05012

Organism
Harpegnathos saltator (Jerdon's jumping ant)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Regulator of G-protein signaling 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EAI_05012Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHarpegnathos saltator (Jerdon's jumping ant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri610380 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataFormicoideaFormicidaePonerinaePoneriniHarpegnathos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008237 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 95PDZInterPro annotationAdd BLAST78
Domaini197 – 297PIDInterPro annotationAdd BLAST101
Domaini632 – 749RGSInterPro annotationAdd BLAST118
Domaini881 – 951RBDInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni369 – 389DisorderedSequence analysisAdd BLAST21
Regioni791 – 810DisorderedSequence analysisAdd BLAST20
Regioni1271 – 1308DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi370 – 389PolarSequence analysisAdd BLAST20
Compositional biasi791 – 809PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1271 – 1287PolarSequence analysisAdd BLAST17

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E2B2P4

KEGG Orthology (KO)

More...
KOi
K16449

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWNGFCH

Database of Orthologous Groups

More...
OrthoDBi
275783at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00640 PID, 1 hit
PF02196 RBD, 1 hit
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 1 hit
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E2B2P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHQNQRRKKK RVNYGVRAVE VIRGAKGFGF TISGQQPCIL SCIVQGSPAE
60 70 80 90 100
NAGLRAGDYL VAVNGHNVSK VPHDDVVQLI GNSKGVLRLQ IAENYYSDSS
110 120 130 140 150
DEEGLATVRS KPKYAHKPRA TNAGALQLQC RVAKVVRDLQ SGAMFHAVGS
160 170 180 190 200
STMSENKDHY GYSGLHYRWN MTSPLPPPPP PVSHKRDSEK IVHRTVVGYL
210 220 230 240 250
GTIDIPNQLH SSCMMQVLRK CIKRLKAEKR NPTTVLLTIH VANIKLTNSE
260 270 280 290 300
NRVIAEYPSY RIIFCNSFSE QDKQYFGILT KSMRDTDDIV SNSCHVFTIY
310 320 330 340 350
YKLIDHQVHS SACNVFGFTC TKSSELNVCQ EFPDSCTNLI GAIQTLYISD
360 370 380 390 400
CTNGETNPYN EARIRLDAAS PQPSNVSTST AHSSNSDSGI GFKDDYGSCS
410 420 430 440 450
GKNTANDCGR RRQCPSNMQY RNVTARTSRE SISEAAGHRL AVRATSEVRW
460 470 480 490 500
NKELKFDPAK EMRLTVGNSG GTTTTCVPAG TSAPVAAAVT TTAVRGCALA
510 520 530 540 550
STSVGSLASV CTTAMLDGIE DDTAESSRTT SSTEKTKQRF TDAINNKLSP
560 570 580 590 600
KVYCGQVTKS LVHSLEDVNS SMEYARPFCH SYTGKQDKPR PWGSLQEIRN
610 620 630 640 650
LGNSVSDNCI HGSTESCDKN NDCKGVHMWA NGFEKLLDDP KGLQTFAEFL
660 670 680 690 700
KKEFSHENIY FWAACERYKD TKDAATRHRL ACQIYQRHLS STAAEPVNVD
710 720 730 740 750
SHASGQITQE LLDEAPADLF LQAQKQVFNL MKFDSYPRFL RSELYRACLE
760 770 780 790 800
AGTAIVNTED CDLHLTSSPS VKLKKSHSDA EDRCRKSILP WNRKNRSKSK
810 820 830 840 850
DRGETEYNKV PSRSETIYKS FTAIKRETEG NNNEDSVSIS SSRSSLASWD
860 870 880 890 900
LALRQSFNKH SVSSCEGQAN DKKEARNKCT GLCRVILPDG STTVVTTSQT
910 920 930 940 950
DSIKDVVTRL LDKRALRYIN YDVLILATDE MVDTKCPSSV LASQEVEVVL
960 970 980 990 1000
TKVLKVELPS RRIISIIAHK GKTLKDVLRP LLNKYGFNLD LISIWSEGHC
1010 1020 1030 1040 1050
VPMDVMAINA PTRLIIMANE EDFQRELHTA KYLDELPHAQ PTLDEITNKV
1060 1070 1080 1090 1100
FEELLVGKSR NKYQYSEGSC KSDDQRSEGS SILSSKFFLR DSTIHGKKKA
1110 1120 1130 1140 1150
KSKCCNTSEK GNTNDCIHEG APVKSQPPLI AKWRNGVKLQ LPGRFDGDDL
1160 1170 1180 1190 1200
YEGLKRAQRS RLEDQRGTEI NFELPDFLKN KENGKPSDCN KMRRSRVVSA
1210 1220 1230 1240 1250
NCEGTTKFYD SNEDKQSCSS GYEYPAHVTN GGGVNERFSA LVNITEPLSK
1260 1270 1280 1290 1300
CLDSSFTLDG DRTLVDGDQT VIENGTSPQS KTLHSGSYGA DASRAKLPKP
1310 1320 1330
PPLPPKPKNL VVNVVKSGYI MSPKSLQRSN HVIE
Length:1,334
Mass (Da):147,872
Last modified:November 30, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53F827191EB30EDF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL445210 Genomic DNA Translation: EFN90026.1

NCBI Reference Sequences

More...
RefSeqi
XP_011148967.1, XM_011150665.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
105188916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hst:105188916

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL445210 Genomic DNA Translation: EFN90026.1
RefSeqiXP_011148967.1, XM_011150665.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi105188916
KEGGihst:105188916

Phylogenomic databases

InParanoidiE2B2P4
KOiK16449
OMAiHWNGFCH
OrthoDBi275783at2759

Family and domain databases

Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00640 PID, 1 hit
PF02196 RBD, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 1 hit
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE2B2P4_HARSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E2B2P4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 17, 2020
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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