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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Haemophilus influenzae (strain 10810)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163GTPUniRule annotation1
Binding sitei167GTPUniRule annotation1
Binding sitei211GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 30GTPUniRule annotation5
Nucleotide bindingi132 – 134GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF862964:G1GWT-1374-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:HIB_13000Imported
OrganismiHaemophilus influenzae (strain 10810)Imported
Taxonomic identifieri862964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000008964 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 229TubulinInterPro annotationAdd BLAST212
Domaini231 – 352Tubulin_CInterPro annotationAdd BLAST122

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

KOiK03531
OMAiMRAVKGI
OrthoDBiPOG091H02KK

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

E1X6W4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYPEYPEYD NFNESGALIK VVGVGGGGGN AVNHMVMNMV KQEMGGTFVG
60 70 80 90 100
ESSLTSEEHG RIVFYAVNTD AQALRKSQVQ QTVQIGGETT KGLGAGANPN
110 120 130 140 150
IGRKAAEDDQ DEIRKMLEGA DMVFIAAGMG GGTGTGAAPV VAKIAKELGI
160 170 180 190 200
LTVAVVTKPF AFEGKKRMQF AELGIKDLSQ YVDSMIIIPN QQIQKVLPKN
210 220 230 240 250
AKLIDAFAAA NDVLRNSVMG ISDMITSPGL INVDFADVRT VMSVQGQAMI
260 270 280 290 300
GFGSAVGEPG AGRAEEAARL AVRNDLLEKI DLSNAQGILV NITAGMDLVF
310 320 330 340 350
EEFNIIGETI GSFASEEATV VVGTSLVPEM SDEIRVTIVA TGLGEIAGNE
360 370 380 390 400
PIQVVRQGLS TQNIEEGEGR VNIVPELHRR ESVEVSRTAS EEYQRPLDKP
410 420
ITDRLEAFKK NNFFNPAQRE EN
Length:422
Mass (Da):45,121
Last modified:November 30, 2010 - v1
Checksum:iFF1965BCE026FD4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312006 Genomic DNA Translation: CBW29487.1
RefSeqiWP_015702080.1, NC_016809.1

Genome annotation databases

EnsemblBacteriaiCBW29487; CBW29487; HIB_13000
KEGGihiu:HIB_13000
PATRICifig|862964.3.peg.1349

Similar proteinsi

Entry informationi

Entry nameiE1X6W4_HAEI1
AccessioniPrimary (citable) accession number: E1X6W4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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