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UniProtKB - E1W822 (AROP_SALTS)
Protein
Aromatic amino acid transport protein AroP
Gene
aroP
Organism
Salmonella typhimurium (strain SL1344)
Status
Functioni
Permease that is involved in the active transport across the cytoplasmic membrane of all three aromatic amino acids, phenylalanine, tyrosine and tryptophan.
By similarityCatalytic activityi
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
GO - Biological processi
- amino acid transport Source: UniProtKB-KW
- transmembrane transport Source: InterPro
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Aromatic amino acid transport protein AroPBy similarityAlternative name(s): Aromatic amino acid:H(+) symporter AroPBy similarity General aromatic amino acid permeaseBy similarity |
Gene namesi | Name:aroP Ordered Locus Names:SL1344_0150 |
Organismi | Salmonella typhimurium (strain SL1344) |
Taxonomic identifieri | 216597 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 42 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 86 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 117 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 155 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 201 | PeriplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 223 – 240 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 271 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 272 – 292 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 333 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 358 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 359 – 379 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 380 – 400 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 425 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 426 – 446 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 447 – 457 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000405410 | 1 – 457 | Aromatic amino acid transport protein AroPAdd BLAST | 457 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_007946_9_3_6 |
OMAi | IFMIVRA |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
E1W822-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMDSQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL
60 70 80 90 100
GYAIAGFIAF LIMRQLGEMV VEEPVAGSFS HFAYKYWGGF AGFASGWNYW
110 120 130 140 150
VLYVLVAMAE LTAVGKYIQF WYPEIPTWAS AAAFFVIINA INLTNVKVFG
160 170 180 190 200
EMEFWFAIIK VIAVIAMILF GAWLLFSDTA GPQATVRNLW EQGGFLPHGW
210 220 230 240 250
TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ VIYRILIFYI
260 270 280 290 300
GSLAVLLSLL PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY
310 320 330 340 350
NSCVYCNSRM LFGLAQQGNA PKALLNVDKR GVPVSSILVS AVVTALCVLL
360 370 380 390 400
NYLAPESAFG LLMALVVSAL VINWAMISLA HMMFRRAKQQ QGVKTRFPAL
410 420 430 440 450
FYPFGNVLCL LFMAAVLIIM LMTPGMAISV WLIPVWLLIL GVGYLCKEKT
AKTVKAH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ242516 Genomic DNA Translation: CAB89839.1 FQ312003 Genomic DNA Translation: CBW16253.1 |
RefSeqi | WP_000969487.1, NZ_QASL01000007.1 |
Genome annotation databases
EnsemblBacteriai | CBW16253; CBW16253; SL1344_0150 |
KEGGi | sey:SL1344_0150 |
PATRICi | fig|216597.6.peg.167 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ242516 Genomic DNA Translation: CAB89839.1 FQ312003 Genomic DNA Translation: CBW16253.1 |
RefSeqi | WP_000969487.1, NZ_QASL01000007.1 |
3D structure databases
SMRi | E1W822 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CBW16253; CBW16253; SL1344_0150 |
KEGGi | sey:SL1344_0150 |
PATRICi | fig|216597.6.peg.167 |
Phylogenomic databases
HOGENOMi | CLU_007946_9_3_6 |
OMAi | IFMIVRA |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AROP_SALTS | |
Accessioni | E1W822Primary (citable) accession number: E1W822 Secondary accession number(s): P0A187, Q8Z9F1, Q9L4I0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 23, 2022 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |