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Protein

Protein SOGA1

Gene

Soga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.1 Publication

GO - Biological processi

  • insulin receptor signaling pathway Source: UniProtKB
  • negative regulation of gluconeogenesis Source: UniProtKB
  • regulation of autophagy Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOGA1
Alternative name(s):
SOGA family member 1
Suppressor of glucose by autophagy
Suppressor of glucose, autophagy-associated protein 1
Cleaved into the following 2 chains:
C-terminal 80 kDa form
Short name:
80-kDa SOGA fragment
Gene namesi
Name:Soga1
Synonyms:Soga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444575 Soga1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004180511 – 1418Protein SOGA1Add BLAST1418
ChainiPRO_00004180521 – 686N-terminal formAdd BLAST686
ChainiPRO_0000418053687 – 1418C-terminal 80 kDa formAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei929PhosphoserineBy similarity1
Modified residuei1015PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma (By similarity). Proteolytically cleaved in primary hepatocytes into a C-terminal SOGA 80 kDa form.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei686 – 687CleavageCurated2

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiE1U8D0
PaxDbiE1U8D0
PeptideAtlasiE1U8D0
PRIDEiE1U8D0

PTM databases

iPTMnetiE1U8D0
PhosphoSitePlusiE1U8D0

Expressioni

Tissue specificityi

Expressed in liver (at protein level).1 Publication

Inductioni

Up-regulated by adiponectin in primary hepatocytes through the insulin signaling pathway. Down-regulated by amino-imidazole carboxamide riboside (AICAR), an AMPK activator that potentiated insulin secretion.1 Publication

Interactioni

Subunit structurei

The C-terminal SOGA 25 kDa form occurs as a monomer.1 Publication

Protein-protein interaction databases

IntActiE1U8D0, 4 interactors
STRINGi10090.ENSMUSP00000066556

Structurei

3D structure databases

SMRiE1U8D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 76Sequence analysisAdd BLAST70
Coiled coili105 – 149Sequence analysisAdd BLAST45
Coiled coili191 – 384Sequence analysisAdd BLAST194
Coiled coili603 – 663Sequence analysisAdd BLAST61
Coiled coili787 – 817Sequence analysisAdd BLAST31
Coiled coili875 – 915Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the SOGA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4787 Eukaryota
ENOG410XUHJ LUCA
InParanoidiE1U8D0

Family and domain databases

InterProiView protein in InterPro
IPR027882 DUF4482
IPR027881 SOGA
PfamiView protein in Pfam
PF14818 DUF4482, 1 hit
PF11365 SOGA, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1U8D0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEMRDVYME EDVYQLQELR QQLDQASKTC RILQYRLRKA ERRSLRAAQT
60 70 80 90 100
GQVDGELIRG LEQDVKVSKD ISMRLHKELE VVEKKRMRLE EENEGLRQRL
110 120 130 140 150
IETELAKQVL QTELDRPREH SLKKRGTRSL GKTDKKPTAQ EDSADLKCQL
160 170 180 190 200
HFAKEESALM CKKLTKLAKE NDSMKEELLK YRSLYGDLDA ALSAEELADA
210 220 230 240 250
PHSRETELKV HLKLVEEEAN LLSRRIVELE VENRGLRAEM DDMKDHGGGG
260 270 280 290 300
GPEARLAFSS LGGECGESLA ELRRHLQFVE EEAELLRRSS AELEDQNKLL
310 320 330 340 350
LNELAKYRSE HELDVTLSED SCSVLSEPSQ EELAAAKLQI GELSGKVKKL
360 370 380 390 400
QYENRVLLSN LQRCDLASCQ STRPMLETDA EAGDSAQCVP APLGETLEPH
410 420 430 440 450
AARLCRAREA EALPGLREQA ALVSKAIDVL VADANGFSVG LRLCLDNECA
460 470 480 490 500
DLRLHEAPDN SEGPRDAKLI HAILVRLSVL QQELNAFTRK ADVALGSSGK
510 520 530 540 550
EQPEPFPALP ALGSQGPAKE IMLSKDLGSD FQPPDFRDLL EWEPRIREAF
560 570 580 590 600
RTGDLESKPD PSRNFRPYRA EDNDSYASEI KDLQLVLAEA HDSLRGLQEQ
610 620 630 640 650
LSQERQLRKE EADSFNQKMV QLKEDQQRAL LRREFELQSL SLQRRLEQKF
660 670 680 690 700
WSQEKNILVQ ESQQFKHNFL LLFMKLRWFL KRWRQGKVLP SEEDDFLEVN
710 720 730 740 750
SMKELYLLME EEEMNAQHSD NKACTGESWT QNTPNECIKT LADMKVTLKE
760 770 780 790 800
LCWLLQDERR GLTELQQQFA KAKATWETER AELKGHASQM ELKAGKGASE
810 820 830 840 850
RPGPDWKAAL QREREEQQHL LAESYSAVME LTRQLQLSER HWSQEKLQLV
860 870 880 890 900
ERLQGEKQQV EQQVKELQNR LSQLQKAAEP WVLKHSDMEK QDNSWKEARS
910 920 930 940 950
EKTHDKEGVS EAELGGTGLK RTKSVSSMSE FESLLDCSPY LAGGDARNKK
960 970 980 990 1000
LPNGPAFAFV STEPVEPEKD AKEKAGLSTR DCSHIGSLAC QEPAGRQMQR
1010 1020 1030 1040 1050
SYTAPDKTGI RVYYSPPVAR RLGVPVVHDK EGKILIEPGF LFTTAKPKES
1060 1070 1080 1090 1100
AEADGLAESS YSRWLCNFSR QRLDGGSGAS TSGSGPAFPA LHDFEMSGNM
1110 1120 1130 1140 1150
SDDMKEITNC VRQAMRSGSL ERKVKNTSSQ TVGVATVGTQ TIRTVSVGLQ
1160 1170 1180 1190 1200
TDPPRSSLHS KSWSPRSSSL VSVRSKQISS SLDKVHSRIE RPCCSPKYGS
1210 1220 1230 1240 1250
PKLQRRSVSK LDSTKDRSLW NLHQGKQNGS AWARSTTTRD SPVLRNINDG
1260 1270 1280 1290 1300
LSSLFSVVEH SGSTESVWKL GMSEARTKPE PPKYGIVQEF FRNVCGRAPS
1310 1320 1330 1340 1350
PTTAAGEESC KKPEPLSPAS YHQPEGVSRI LNKKAAKAGG SEEVRPTMLS
1360 1370 1380 1390 1400
QVGKDGILRD GDGSLILPSE DAVCDCSAQS LASCFIRPSR NTIRHSPSKC
1410
RLHPSESGWG GEERAAPQ
Length:1,418
Mass (Da):159,186
Last modified:July 11, 2012 - v3
Checksum:i4A36FE0AF8E22827
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ACV6A2ACV6_MOUSE
Protein SOGA1
Soga1 9830001H06Rik
1,654Annotation score:

Sequence cautioni

The sequence ADC34694 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence DAA34787 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ977045 mRNA Translation: ADC34694.2 Different initiation.
BK007093 Genomic DNA Translation: DAA34787.1 Different initiation.
UniGeneiMm.79466

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ977045 mRNA Translation: ADC34694.2 Different initiation.
BK007093 Genomic DNA Translation: DAA34787.1 Different initiation.
UniGeneiMm.79466

3D structure databases

SMRiE1U8D0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE1U8D0, 4 interactors
STRINGi10090.ENSMUSP00000066556

PTM databases

iPTMnetiE1U8D0
PhosphoSitePlusiE1U8D0

Proteomic databases

MaxQBiE1U8D0
PaxDbiE1U8D0
PeptideAtlasiE1U8D0
PRIDEiE1U8D0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2444575 Soga1

Phylogenomic databases

eggNOGiKOG4787 Eukaryota
ENOG410XUHJ LUCA
InParanoidiE1U8D0

Miscellaneous databases

ChiTaRSiSoga1 mouse
PROiPR:E1U8D0
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR027882 DUF4482
IPR027881 SOGA
PfamiView protein in Pfam
PF14818 DUF4482, 1 hit
PF11365 SOGA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSOGA1_MOUSE
AccessioniPrimary (citable) accession number: E1U8D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 11, 2012
Last modified: May 23, 2018
This is version 38 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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