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Protein

Multifunctional fusion protein

Gene

purE

Organism
Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Multifunctional fusion protein (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (purF)
  2. Multifunctional fusion protein (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei437SubstrateUniRule annotation1
Binding sitei440SubstrateUniRule annotation1
Binding sitei467SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation, LigaseUniRule annotationImported, LyaseImported
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDBAA644282:G1GM5-166-MONOMER
UniPathwayi
UPA00074;UER00125

UPA00074;UER00943

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
GARSUniRule annotation
Glycinamide ribonucleotide synthetaseUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation
Gene namesi
Name:purEUniRule annotation
Synonyms:purDUniRule annotation
Ordered Locus Names:Deba_0168Imported
OrganismiDesulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)Imported
Taxonomic identifieri644282 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfarculalesDesulfarculaceaeDesulfarculus
Proteomesi
  • UP000009047 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi644282.Deba_0168

Structurei

3D structure databases

ProteinModelPortaliE1QDM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 314ATP-graspInterPro annotationAdd BLAST208

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili566 – 586Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AIR carboxylase family. Class I subfamily.UniRule annotation
Belongs to the GARS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C12 Bacteria
COG0041 LUCA
COG0151 LUCA
HOGENOMiHOG000033463
KOiK01945
OMAiKATVCKY
OrthoDBiPOG091H02DZ

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.50.7700, 1 hit
3.90.600.10, 1 hit
HAMAPiMF_00138 GARS, 1 hit
MF_01929 PurE_classI, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR020561 PRibGlycinamid_synth_ATP-grasp
IPR000115 PRibGlycinamide_synth
IPR020560 PRibGlycinamide_synth_C-dom
IPR037123 PRibGlycinamide_synth_C_sf
IPR020559 PRibGlycinamide_synth_CS
IPR020562 PRibGlycinamide_synth_N
IPR033747 PurE_ClassI
IPR000031 PurE_dom
IPR035893 PurE_sf
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PF01071 GARS_A, 1 hit
PF02843 GARS_C, 1 hit
PF02844 GARS_N, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SM01210 GARS_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52255 SSF52255, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR00877 purD, 1 hit
TIGR01162 purE, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00184 GARS, 1 hit

Sequencei

Sequence statusi: Complete.

E1QDM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILVIGGGG REHAIVWKLA QSPKVQAIFC APGNPGMAGL ATCLTIDPDD
60 70 80 90 100
IAGLKAFALD NHIDLTVVGP EAPLVAGLTD VFEQAGLLVA GPSAAAARLE
110 120 130 140 150
GSKAFAKEVM EAAGVPTAQC RIFDDAAQAK DHCRNLGGPV VVKADGLAAG
160 170 180 190 200
KGVIMCRTAG EAMAACERIM EERAFGQAGE RVVIEEWLEG EEASFLVFTD
210 220 230 240 250
GQAIAAMPSS QDHKAVGEGD TGPNTGGMGA YSPAPVVGPA LESAVIERVI
260 270 280 290 300
KPTLAEMKRR GAPFKGVLYA GLMIDKAGEP KVLEFNVRFG DPECQPLLMR
310 320 330 340 350
LDSDLAEILQ LLAQGRLAEA EVEWKADPAV CVVLASGGYP GDYAKGFEIS
360 370 380 390 400
GVEEANAVEG ARVFHAGTAL KDGKLVNAGG RVLGVCATGV DIAQAIERAY
410 420 430 440 450
EACGKIWWQG MLLRRDIGHR ALARLKNRPL VGIVMGSPND WEVMKSAAKA
460 470 480 490 500
LTELGVPHEA RVLSAHRTPG QAAQYAASAA ERGLKVIIAG AGWAAHLAGA
510 520 530 540 550
MAAQTVLPVI GVPIGSSQLN GLDALLSTVQ MPPGIPVATV AIGAGGARNA
560 570 580
GVLAAQILAL GDAALAQGLA QQRRDMAAEV AAAEKKLFA
Length:589
Mass (Da):60,741
Last modified:November 30, 2010 - v1
Checksum:i6C21647540B8649F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002085 Genomic DNA Translation: ADK83547.1
RefSeqiWP_013257003.1, NC_014365.1

Genome annotation databases

EnsemblBacteriaiADK83547; ADK83547; Deba_0168
KEGGidbr:Deba_0168

Similar proteinsi

Entry informationi

Entry nameiE1QDM8_DESB2
AccessioniPrimary (citable) accession number: E1QDM8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 18, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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