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UniProtKB - E1JJE6 (E1JJE6_DROME)
Protein
Submitted name:
Otopetrin-like a, isoform C
Gene
OtopLa
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- proton channel activity Source: GO_Central
GO - Biological processi
- proton transmembrane transport Source: GO_Central
Keywordsi
Biological process | TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Otopetrin-like a, isoform CImported |
Gene namesi | Name:OtopLaImported Synonyms:anon-WO0140519.181Imported, CG11473Imported, CG17761Imported, dm_OtopLaImported, Dmel\CG42492Imported, dmOTOPLaImported ORF Names:CG42492Imported, Dmel_CG42492Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0259994, OtopLa |
VEuPathDBi | VectorBase:FBgn0259994 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 129 – 151 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 272 – 293 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 313 – 334 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 346 – 368 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 706 – 726 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 774 – 794 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 800 – 825 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 846 – 865 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 877 – 898 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 919 – 936 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | FBgn0259994, Expressed in central nervous system and 24 other tissues |
ExpressionAtlasi | E1JJE6, baseline and differential |
Genevisiblei | E1JJE6, DM |
Structurei
3D structure databases
AlphaFoldDBi | E1JJE6 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 58 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 194 – 232 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 452 – 481 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 507 – 555 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 53 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 210 – 230 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 456 – 481 | Polar residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the otopetrin family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG4740, Eukaryota |
InParanoidi | E1JJE6 |
PhylomeDBi | E1JJE6 |
Family and domain databases
InterProi | View protein in InterPro IPR004878, Otopetrin |
PANTHERi | PTHR21522, PTHR21522, 1 hit |
Pfami | View protein in Pfam PF03189, Otopetrin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E1JJE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRCPYIHEM RERLLDQPRE TLQLENMERA NLLDNRQSAS ESNQLQGDGY
60 70 80 90 100
HTSPAHQRTP LVPHDLGEDF NLDFDDDFPI DARRPKNAKV CYTFKPNPNK
110 120 130 140 150
YSFMPAKITV QGTYETNPIT GPIELWTSLF IVTSLVYAIL LIVVCIAYVI
160 170 180 190 200
SDVTTHRLPV LYYETFFTYL YGVSILFLLY VFCFLLQESS CCNGGNGGSK
210 220 230 240 250
PKPQPKEKKS KKAKNADPAD SKDAKGSKDS GKAAKGAAYQ HTLAKFLEAP
260 270 280 290 300
VDAEVAVTPK NVRKRKTTHS DLTHGSFFLR VGAIAFGLGA MIYIGLEFGS
310 320 330 340 350
FFEIPFDSPC HHILIGVNPL LQMIFTFMQM YFIFMNARLN IHRFKVIARF
360 370 380 390 400
GLMHVVATNI CVWIRTLVKE SLLEITIYHQ KNEPEAGASS IAHSIRQHAL
410 420 430 440 450
RHAGTVLRTH AGPNSEFEVL DGEDILPKDV YKSDNVLSKL VRNTVDGISK
460 470 480 490 500
SLGMGGDQAL DSSTTSSSTT TTTRAPFTTP NYQWHSTTMA RKLKKFITSA
510 520 530 540 550
TTAATTAAGS SSTASSTTTI SPTISSTTIP STTISSTTIS SSTTFSPFSP
560 570 580 590 600
STTTTTTTTA AALNLETSGS ESPFGGLQRI LSSAAPPSLA PVDGFGSASA
610 620 630 640 650
ATPTSGSGAG SFVDSFLAST LSPASSTEGS ASIMNNLFGQ GPMENSFQTY
660 670 680 690 700
TDLGHEEATG LVSFENLESL DNIYPAALSS NIGTLNSTAC GRIDIMGTIV
710 720 730 740 750
YDSAPYLYPF IIEYSLIGAV VLYVMWKHIG RYPGRMNDED LEHRLEVMLS
760 770 780 790 800
RRAVAMAQQA RSGRVDCVGS SKGLFFGLLL LVGALICLIL FFVLVRHQQF
810 820 830 840 850
SLLAIYLADA SHCILMAFAI LAIIVGFIRV KNLKFRCEEQ SNLNDILLRI
860 870 880 890 900
SAFGLFTYSV FSIIAGSLKV LESEPSLLVT TTGGVAVFQV ILQLLFIADV
910 920 930 940 950
SRRRVHLPEH DRSKPGRQIV TFLLICNVAM FAIYTFEAQK VFANPVQLEF
960 970 980 990
YGFVPWSIIQ RITLPLCIFH RFHSAVTLAE IWKTTYKARL E
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM9PDU2 | M9PDU2_DROME | Otopetrin-like a, isoform F | OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492 | 917 | Annotation score: | ||
M9PGH2 | M9PGH2_DROME | Otopetrin-like a, isoform G | OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492 | 958 | Annotation score: | ||
M9PGQ4 | M9PGQ4_DROME | Otopetrin-like a, isoform D | OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492 | 977 | Annotation score: | ||
M9PJ56 | M9PJ56_DROME | Otopetrin-like a, isoform E | OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492 | 979 | Annotation score: | ||
Q9W4A6 | Q9W4A6_DROME | Otopetrin-like a, isoform A | OtopLa anon-WO0140519.181, CG17761, dm_OtopLa, Dmel\CG42492, dmOTOPLa | 916 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: ACZ95213.1 |
RefSeqi | NP_001162676.1, NM_001169205.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0300465; FBpp0289692; FBgn0259994 |
GeneIDi | 8674066 |
KEGGi | dme:Dmel_CG42492 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: ACZ95213.1 |
RefSeqi | NP_001162676.1, NM_001169205.2 |
3D structure databases
AlphaFoldDBi | E1JJE6 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0289692 |
PTM databases
SwissPalmi | E1JJE6 |
Proteomic databases
PaxDbi | E1JJE6 |
PRIDEi | E1JJE6 |
Protocols and materials databases
DNASUi | 8674066 |
Genome annotation databases
EnsemblMetazoai | FBtr0300465; FBpp0289692; FBgn0259994 |
GeneIDi | 8674066 |
KEGGi | dme:Dmel_CG42492 |
Organism-specific databases
CTDi | 8674066 |
FlyBasei | FBgn0259994, OtopLa |
VEuPathDBi | VectorBase:FBgn0259994 |
Phylogenomic databases
eggNOGi | KOG4740, Eukaryota |
InParanoidi | E1JJE6 |
PhylomeDBi | E1JJE6 |
Miscellaneous databases
BioGRID-ORCSi | 8674066, 0 hits in 3 CRISPR screens |
ChiTaRSi | CG42492, fly |
GenomeRNAii | 8674066 |
Gene expression databases
Bgeei | FBgn0259994, Expressed in central nervous system and 24 other tissues |
ExpressionAtlasi | E1JJE6, baseline and differential |
Genevisiblei | E1JJE6, DM |
Family and domain databases
InterProi | View protein in InterPro IPR004878, Otopetrin |
PANTHERi | PTHR21522, PTHR21522, 1 hit |
Pfami | View protein in Pfam PF03189, Otopetrin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E1JJE6_DROME | |
Accessioni | E1JJE6Primary (citable) accession number: E1JJE6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |