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UniProtKB - E1JJE6 (E1JJE6_DROME)

Entry version 86 (25 May 2022)
Sequence version 1 (30 Nov 2010)
Previous versions | rss
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Protein
Submitted name:

Otopetrin-like a, isoform C

Gene

OtopLa

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • proton channel activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Otopetrin-like a, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OtopLaImported
Synonyms:anon-WO0140519.181Imported, CG11473Imported, CG17761Imported, dm_OtopLaImported, Dmel\CG42492Imported, dmOTOPLaImported
ORF Names:CG42492Imported, Dmel_CG42492Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0259994, OtopLa

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0259994

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei129 – 151HelicalSequence analysisAdd BLAST23
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei272 – 293HelicalSequence analysisAdd BLAST22
Transmembranei313 – 334HelicalSequence analysisAdd BLAST22
Transmembranei346 – 368HelicalSequence analysisAdd BLAST23
Transmembranei706 – 726HelicalSequence analysisAdd BLAST21
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Transmembranei800 – 825HelicalSequence analysisAdd BLAST26
Transmembranei846 – 865HelicalSequence analysisAdd BLAST20
Transmembranei877 – 898HelicalSequence analysisAdd BLAST22
Transmembranei919 – 936HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E1JJE6

PRoteomics IDEntifications database

More...PRIDEi		E1JJE6

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		E1JJE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0259994, Expressed in central nervous system and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E1JJE6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E1JJE6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0289692

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		E1JJE6

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 58DisorderedSequence analysisAdd BLAST23
Regioni194 – 232DisorderedSequence analysisAdd BLAST39
Regioni452 – 481DisorderedSequence analysisAdd BLAST30
Regioni507 – 555DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 53Polar residuesSequence analysisAdd BLAST18
Compositional biasi210 – 230Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi456 – 481Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the otopetrin family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4740, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E1JJE6

Database for complete collections of gene phylogenies

More...PhylomeDBi		E1JJE6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004878, Otopetrin

The PANTHER Classification System

More...PANTHERi		PTHR21522, PTHR21522, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03189, Otopetrin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E1JJE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRCPYIHEM RERLLDQPRE TLQLENMERA NLLDNRQSAS ESNQLQGDGY 
        60         70         80         90        100
HTSPAHQRTP LVPHDLGEDF NLDFDDDFPI DARRPKNAKV CYTFKPNPNK 
       110        120        130        140        150
YSFMPAKITV QGTYETNPIT GPIELWTSLF IVTSLVYAIL LIVVCIAYVI 
       160        170        180        190        200
SDVTTHRLPV LYYETFFTYL YGVSILFLLY VFCFLLQESS CCNGGNGGSK 
       210        220        230        240        250
PKPQPKEKKS KKAKNADPAD SKDAKGSKDS GKAAKGAAYQ HTLAKFLEAP 
       260        270        280        290        300
VDAEVAVTPK NVRKRKTTHS DLTHGSFFLR VGAIAFGLGA MIYIGLEFGS 
       310        320        330        340        350
FFEIPFDSPC HHILIGVNPL LQMIFTFMQM YFIFMNARLN IHRFKVIARF 
       360        370        380        390        400
GLMHVVATNI CVWIRTLVKE SLLEITIYHQ KNEPEAGASS IAHSIRQHAL 
       410        420        430        440        450
RHAGTVLRTH AGPNSEFEVL DGEDILPKDV YKSDNVLSKL VRNTVDGISK 
       460        470        480        490        500
SLGMGGDQAL DSSTTSSSTT TTTRAPFTTP NYQWHSTTMA RKLKKFITSA 
       510        520        530        540        550
TTAATTAAGS SSTASSTTTI SPTISSTTIP STTISSTTIS SSTTFSPFSP 
       560        570        580        590        600
STTTTTTTTA AALNLETSGS ESPFGGLQRI LSSAAPPSLA PVDGFGSASA 
       610        620        630        640        650
ATPTSGSGAG SFVDSFLAST LSPASSTEGS ASIMNNLFGQ GPMENSFQTY 
       660        670        680        690        700
TDLGHEEATG LVSFENLESL DNIYPAALSS NIGTLNSTAC GRIDIMGTIV 
       710        720        730        740        750
YDSAPYLYPF IIEYSLIGAV VLYVMWKHIG RYPGRMNDED LEHRLEVMLS 
       760        770        780        790        800
RRAVAMAQQA RSGRVDCVGS SKGLFFGLLL LVGALICLIL FFVLVRHQQF 
       810        820        830        840        850
SLLAIYLADA SHCILMAFAI LAIIVGFIRV KNLKFRCEEQ SNLNDILLRI 
       860        870        880        890        900
SAFGLFTYSV FSIIAGSLKV LESEPSLLVT TTGGVAVFQV ILQLLFIADV 
       910        920        930        940        950
SRRRVHLPEH DRSKPGRQIV TFLLICNVAM FAIYTFEAQK VFANPVQLEF 
       960        970        980        990 
YGFVPWSIIQ RITLPLCIFH RFHSAVTLAE IWKTTYKARL E
Length:991
Mass (Da):108,826
Last modified:November 30, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0FB6FD85CC86136
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PDU2M9PDU2_DROME
Otopetrin-like a, isoform F
OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492
917Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGH2M9PGH2_DROME
Otopetrin-like a, isoform G
OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492
958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGQ4M9PGQ4_DROME
Otopetrin-like a, isoform D
OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492
977Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PJ56M9PJ56_DROME
Otopetrin-like a, isoform E
OtopLa anon-WO0140519.181, CG11473, CG17761, dm_OtopLa, Dmel\CG42492
979Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9W4A6Q9W4A6_DROME
Otopetrin-like a, isoform A
OtopLa anon-WO0140519.181, CG17761, dm_OtopLa, Dmel\CG42492, dmOTOPLa
916Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014298 Genomic DNA Translation: ACZ95213.1

NCBI Reference Sequences

More...RefSeqi		NP_001162676.1, NM_001169205.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0300465; FBpp0289692; FBgn0259994

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8674066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG42492

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ACZ95213.1
RefSeqiNP_001162676.1, NM_001169205.2

3D structure databases

AlphaFoldDBiE1JJE6
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0289692

PTM databases

SwissPalmiE1JJE6

Proteomic databases

PaxDbiE1JJE6
PRIDEiE1JJE6

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8674066

Genome annotation databases

EnsemblMetazoaiFBtr0300465; FBpp0289692; FBgn0259994
GeneIDi8674066
KEGGidme:Dmel_CG42492

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8674066
FlyBaseiFBgn0259994, OtopLa
VEuPathDBiVectorBase:FBgn0259994

Phylogenomic databases

eggNOGiKOG4740, Eukaryota
InParanoidiE1JJE6
PhylomeDBiE1JJE6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8674066, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CG42492, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8674066

Gene expression databases

BgeeiFBgn0259994, Expressed in central nervous system and 24 other tissues
ExpressionAtlasiE1JJE6, baseline and differential
GenevisibleiE1JJE6, DM

Family and domain databases

InterProiView protein in InterPro
IPR004878, Otopetrin
PANTHERiPTHR21522, PTHR21522, 1 hit
PfamiView protein in Pfam
PF03189, Otopetrin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1JJE6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1JJE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 25, 2022
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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