UniProtKB - E1JI91 (E1JI91_DROME)
Protein
UTP--glucose-1-phosphate uridylyltransferase
Gene
UGP
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.ARBA annotation
Catalytic activityi
- EC:2.7.7.9UniRule annotation
: glycogen biosynthesis Pathwayi
This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.ARBA annotationView all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 136 | UTPUniRule annotation | 1 | |
Binding sitei | 199 | UTPUniRule annotation | 1 | |
Binding sitei | 230 | UTP; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 231 | SubstrateUniRule annotation | 1 | |
Binding sitei | 261 | UTPUniRule annotation | 1 | |
Binding sitei | 405 | UTPUniRule annotation | 1 |
GO - Molecular functioni
- UTP:glucose-1-phosphate uridylyltransferase activity Source: FlyBase
GO - Biological processi
- glycogen metabolic process Source: GO_Central
- response to hyperoxia Source: FlyBase
- UDP-glucose metabolic process Source: FlyBase
Keywordsi
Molecular function | NucleotidyltransferaseUniRule annotationImported, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00164 |
Names & Taxonomyi
Protein namesi | Recommended name: UTP--glucose-1-phosphate uridylyltransferaseUniRule annotationARBA annotation (EC:2.7.7.9UniRule annotationARBA annotation) |
Gene namesi | Name:UGPImported Synonyms:Dmel\CG4347Imported, dUGPImported, UDPGPPImported, UGP-REImported, UGPaseImported ORF Names:CG4347Imported, Dmel_CG4347Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0035978, UGP |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | FBgn0035978, Expressed in capitellum (Drosophila) and 30 other tissues |
Interactioni
Subunit structurei
Homooctamer.
ARBA annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000153464 |
HOGENOMi | CLU_023632_3_0_1 |
OMAi | YLNRTYD |
OrthoDBi | 503037at2759 |
Family and domain databases
CDDi | cd00897, UGPase_euk, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR002618, UDPGP_fam IPR016267, UDPGP_trans |
Pfami | View protein in Pfam PF01704, UDPGP, 1 hit |
PIRSFi | PIRSF000806, UDPGP, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E1JI91-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSGIRPIDV LLERAGVRGH QRAPSDSKEF HEVTKRDALR LLEHDVDRLL
60 70 80 90 100
ETTEKARQPA LKAEMGRFAD LFGRFIQEEG PALDWNKIQK LPENAVMNYS
110 120 130 140 150
NLKSPKNEQI RNMLDKLVVI KLNGGLGTSM GCHGPKSVIP VRSDLTFLDL
160 170 180 190 200
TVQQIEHLNK TYDANVPLVL MNSFNTDEDT EKIVRKYKGF RVQIHTFNQS
210 220 230 240 250
CFPRISREHY LPVAKDFDVE KDMEAWYPPG HGDFYDTFRN SGLLKKFIEE
260 270 280 290 300
GREYCFLSNI DNLGATVDLN ILNKLVGEER ATTPVEFVME VTDKTRADVK
310 320 330 340 350
GGTLIQMENK LRLLEIAQVP PEHVDDFKSV KTFKFFNTNN IWANLAAIDR
360 370 380 390 400
VLRERTLNME IIVNNKTLEN GTRVIQLETA VGAAMKCFDG AIGINVPRSR
410 420 430 440 450
FLPVKKSSDL LLVMSNLYTL KNGSLVMSPQ RMFPTTPLVK LGENHFSKVK
460 470 480 490 500
EFLGRFANIP DIIELDHLTV SGDVTFGRGV SLRGTVIIIA NHGDRIDIPA
510
GAILENKIVS GNMRILDH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA5XCL5 | A5XCL5_DROME | UTP--glucose-1-phosphate uridylyltr... | UGP Dmel\CG4347, dUGP, UDPGPP, UGP-RD, UGPase | 511 | Annotation score: | ||
Q9VSW2 | Q9VSW2_DROME | UTP--glucose-1-phosphate uridylyltr... | UGP Dmel\CG4347, dUGP, UDPGPP, UGPase, CG4347 | 513 | Annotation score: | ||
Q9VSW1 | Q9VSW1_DROME | UTP--glucose-1-phosphate uridylyltr... | UGP Dmel\CG4347, dUGP, UDPGPP, UGPase, CG4347 | 520 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: ACZ94671.1 BT133238 mRNA Translation: AFB18661.1 |
RefSeqi | NP_001163400.1, NM_001169929.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0301699; FBpp0290913; FBgn0035978 |
GeneIDi | 39065 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: ACZ94671.1 BT133238 mRNA Translation: AFB18661.1 |
RefSeqi | NP_001163400.1, NM_001169929.2 |
3D structure databases
SMRi | E1JI91 |
ModBasei | Search... |
Proteomic databases
PRIDEi | E1JI91 |
Genome annotation databases
EnsemblMetazoai | FBtr0301699; FBpp0290913; FBgn0035978 |
GeneIDi | 39065 |
Organism-specific databases
CTDi | 39065 |
FlyBasei | FBgn0035978, UGP |
Phylogenomic databases
GeneTreei | ENSGT00940000153464 |
HOGENOMi | CLU_023632_3_0_1 |
OMAi | YLNRTYD |
OrthoDBi | 503037at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00164 |
Miscellaneous databases
BioGRID-ORCSi | 39065, 1 hit in 1 CRISPR screen |
ChiTaRSi | UGP, fly |
GenomeRNAii | 39065 |
Gene expression databases
Bgeei | FBgn0035978, Expressed in capitellum (Drosophila) and 30 other tissues |
Family and domain databases
CDDi | cd00897, UGPase_euk, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR002618, UDPGP_fam IPR016267, UDPGP_trans |
Pfami | View protein in Pfam PF01704, UDPGP, 1 hit |
PIRSFi | PIRSF000806, UDPGP, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E1JI91_DROME | |
Accessioni | E1JI91Primary (citable) accession number: E1JI91 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |