Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 95 (16 Oct 2019)
Sequence version 1 (30 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Uninflatable, isoform C

Gene

uif

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uninflatable, isoform CImported
Submitted name:
Uninflatable, isoform DImported
Submitted name:
Uninflatable, isoform EImported
Submitted name:
Uninflatable, isoform FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uifImported
Synonyms:CT26172Imported, Dmel\CG9138Imported, Poly-EGFImported, poly-EGFImported, SP1070Imported, sp1070Imported, UifImported
ORF Names:CG9138Imported, Dmel_CG9138Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031879 uif

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3447 – 3473HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508869431 – 3589Sequence analysisAdd BLAST3559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi172 ↔ 184PROSITE-ProRule annotation
Disulfide bondi179 ↔ 197PROSITE-ProRule annotation
Disulfide bondi191 ↔ 206PROSITE-ProRule annotation
Disulfide bondi439 ↔ 466PROSITE-ProRule annotation
Disulfide bondi552 ↔ 595PROSITE-ProRule annotation
Disulfide bondi675 ↔ 718PROSITE-ProRule annotation
Disulfide bondi704 ↔ 731PROSITE-ProRule annotation
Disulfide bondi1079 ↔ 1106PROSITE-ProRule annotation
Disulfide bondi2047 ↔ 2056PROSITE-ProRule annotation
Disulfide bondi2085 ↔ 2094PROSITE-ProRule annotation
Disulfide bondi2106 ↔ 2123PROSITE-ProRule annotation
Disulfide bondi2125 ↔ 2134PROSITE-ProRule annotation
Disulfide bondi2166 ↔ 2175PROSITE-ProRule annotation
Disulfide bondi2204 ↔ 2213PROSITE-ProRule annotation
Disulfide bondi2220 ↔ 2230PROSITE-ProRule annotation
Disulfide bondi2241 ↔ 2250PROSITE-ProRule annotation
Disulfide bondi2279 ↔ 2288PROSITE-ProRule annotation
Disulfide bondi2317 ↔ 2326PROSITE-ProRule annotation
Disulfide bondi2338 ↔ 2355PROSITE-ProRule annotation
Disulfide bondi2357 ↔ 2366PROSITE-ProRule annotation
Disulfide bondi2395 ↔ 2404PROSITE-ProRule annotation
Disulfide bondi2434 ↔ 2443PROSITE-ProRule annotation
Disulfide bondi2472 ↔ 2481PROSITE-ProRule annotation
Disulfide bondi2510 ↔ 2519PROSITE-ProRule annotation
Disulfide bondi2548 ↔ 2557PROSITE-ProRule annotation
Disulfide bondi3372 ↔ 3382PROSITE-ProRule annotation
Disulfide bondi3376 ↔ 3393PROSITE-ProRule annotation
Disulfide bondi3410 ↔ 3420PROSITE-ProRule annotation
Disulfide bondi3432 ↔ 3441PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E1JHA6

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E1JHA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031879 Expressed in 18 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1JHA6 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1JHA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 168C-type lectinInterPro annotationAdd BLAST126
Domaini210 – 322CUBInterPro annotationAdd BLAST113
Domaini326 – 438CUBInterPro annotationAdd BLAST113
Domaini439 – 551CUBInterPro annotationAdd BLAST113
Domaini550 – 611SushiInterPro annotationAdd BLAST62
Domaini612 – 672SushiInterPro annotationAdd BLAST61
Domaini673 – 733SushiInterPro annotationAdd BLAST61
Domaini734 – 792SushiInterPro annotationAdd BLAST59
Domaini792 – 830EGF-likeInterPro annotationAdd BLAST39
Domaini829 – 977F5/8 type CInterPro annotationAdd BLAST149
Domaini1049 – 1108SushiInterPro annotationAdd BLAST60
Domaini1185 – 1248SushiInterPro annotationAdd BLAST64
Domaini1298 – 1444F5/8 type CInterPro annotationAdd BLAST147
Domaini1463 – 1549HYRInterPro annotationAdd BLAST87
Domaini1550 – 1633HYRInterPro annotationAdd BLAST84
Domaini1634 – 1698SushiInterPro annotationAdd BLAST65
Domaini2021 – 2057EGF-likeInterPro annotationAdd BLAST37
Domaini2059 – 2095EGF-likeInterPro annotationAdd BLAST37
Domaini2097 – 2135EGF-likeInterPro annotationAdd BLAST39
Domaini2137 – 2176EGF-likeInterPro annotationAdd BLAST40
Domaini2178 – 2214EGF-likeInterPro annotationAdd BLAST37
Domaini2216 – 2251EGF-likeInterPro annotationAdd BLAST36
Domaini2253 – 2289EGF-likeInterPro annotationAdd BLAST37
Domaini2291 – 2327EGF-likeInterPro annotationAdd BLAST37
Domaini2329 – 2367EGF-likeInterPro annotationAdd BLAST39
Domaini2369 – 2405EGF-likeInterPro annotationAdd BLAST37
Domaini2407 – 2444EGF-likeInterPro annotationAdd BLAST38
Domaini2446 – 2482EGF-likeInterPro annotationAdd BLAST37
Domaini2484 – 2520EGF-likeInterPro annotationAdd BLAST37
Domaini2522 – 2558EGF-likeInterPro annotationAdd BLAST37
Domaini2799 – 2881HYRInterPro annotationAdd BLAST83
Domaini2882 – 2952SushiInterPro annotationAdd BLAST71
Domaini3368 – 3405EGF-likeInterPro annotationAdd BLAST38
Domaini3407 – 3442EGF-likeInterPro annotationAdd BLAST36

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155152

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQYSGFW

Database of Orthologous Groups

More...
OrthoDBi
2171at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 3 hits
cd00041 CUB, 3 hits
cd00112 LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.120.290, 3 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR003410 HYR_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 3 hits
PF00008 EGF, 8 hits
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 7 hits
PF00754 F5_F8_type_C, 2 hits
PF12661 hEGF, 3 hits
PF02494 HYR, 3 hits
PF00057 Ldl_recept_a, 1 hit
PF00084 Sushi, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 8 hits
SM00034 CLECT, 1 hit
SM00042 CUB, 3 hits
SM00181 EGF, 21 hits
SM00179 EGF_CA, 15 hits
SM01411 Ephrin_rec_like, 7 hits
SM00231 FA58C, 2 hits
SM00192 LDLa, 1 hit
SM00208 TNFR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 3 hits
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 4 hits
SSF57424 SSF57424, 1 hit
SSF57535 SSF57535, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 3 hits
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 17 hits
PS01187 EGF_CA, 6 hits
PS01285 FA58C_1, 1 hit
PS50022 FA58C_3, 2 hits
PS50825 HYR, 3 hits
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS50923 SUSHI, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1JHA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQSTAANSH WLAALLSSLL LLNLLHLIGA DEAFSCPNGW ELRGLNCYKY
60 70 80 90 100
FNIKHSWDKS AELCRRYGAE LVAIDSYAEN NETLAIARAS DPNQRASDKY
110 120 130 140 150
WLGLASLDDL RTNTLESASG ALISQYSGYW SLHQPNAESG ECVAAAFAGK
160 170 180 190 200
SQSWDLGTCE SLLPFMCRAQ ACPQGSLHCA NGKCINQAFK CDGSDDCGDG
210 220 230 240 250
TDELDCPAQC HYHMQSGGDV IETPNYPHKY GALSKCKWTL EGPLGSNIIL
260 270 280 290 300
QFQDFETEKT FDTVQILVGG RTEDKSVSLA TLSGKQDLTT QPFVSASNFM
310 320 330 340 350
IVKFTTDGSV ERKGFRATWK TEAKNCGGTL KATLQRQILT SPNYPKQYPG
360 370 380 390 400
GLECLYVIKA QPGRIISIEV DDLDIADGRD FLMIRDGESP MSRTIAKLTG
410 420 430 440 450
KTAQNNRVII STGNALYLYF KSSLGEAGKG FSLRYIQGCK ATITARNGTV
460 470 480 490 500
TSPAFGLADY PKNQECYFTI RNNARAPLSL KFDKFTVHKS DNVQVFDGSS
510 520 530 540 550
TSGLRLHSGN GFTGPAAPKL TLTASSGEML IKFTSDALHN AAGWSATFSA
560 570 580 590 600
DCPELQPGIG ALASSRDTAF GTLVSFTCPI GQEFATGKTR LVTECLRGGN
610 620 630 640 650
WSVSYIPKCQ EVYCGPVPQI DNGFSIGSSN VTYRGIAMYQ CYAGFAFASG
660 670 680 690 700
APIEKISCLP DGRWERQPHC MASQCAALPE VAHANVTLLN GGGRSYGTIV
710 720 730 740 750
QYECEPGYER NGHPVLTCMS NGTWSGDVPR CTRKRCFEFP TIANGFVVDS
760 770 780 790 800
TRAYLFGDEA RVQCFKGYKL IGSNIMRCSE AQKFEQPPTC EDINECSSSQ
810 820 830 840 850
CDLTTTECQN TNGSFHCQCR TGFTATTECR PVGDLGLGNG GIPDDSITTS
860 870 880 890 900
VSEPGYSKEQ LRLNTNGWCG GSSEPGANWI LIDLKAPTIL RGFRTMSVQR
910 920 930 940 950
PDGNVAFSSA VRLQYTNDLT DVFKDYANPD GTAVEFRILE PTLSILNLPL
960 970 980 990 1000
PIEARYIRFR IQDYVGAPCL RMELMGCTRL DCVDINECSK NNGGCDQKCI
1010 1020 1030 1040 1050
NSPGGFACGC NTGYQLYTSN GTAGYHIERS ESGERDGDTY QRNKTCVPLM
1060 1070 1080 1090 1100
CPELEAPENG QLLSDKNDYH FGDVVRFQCH FGYIMSGSSA ALCLSSGQWN
1110 1120 1130 1140 1150
ASVPECNYAK CVSLPDDKLE GLTVARPDPE SVLVPFRDNV TITCGSPGRQ
1160 1170 1180 1190 1200
LRATASSGFR QCVYDPKPGL PDYWLSGMQP SCPRVDCYSP MPTPGAEYGQ
1210 1220 1230 1240 1250
FVDTRYQSSF FFGCQNTFKL AGQTGRHDNV VRCGADGIWD FGDLRCEGPV
1260 1270 1280 1290 1300
CEDPGRPADG RQIARSYEQS SEVYFGCNRP GYILINPRPI TCIREPECKV
1310 1320 1330 1340 1350
IKPLGLSSGR IPDSAINATS ERPNYEAKNI RLNSATGWCG KQEAFTYVSV
1360 1370 1380 1390 1400
DLGQIYRVKA ILVKGVVTND IVGRPTEIRF FYKQAESENY VVYFPNFNLT
1410 1420 1430 1440 1450
MRDPGNYGEL AMITLPKFVQ ARFVILGIVS YMDNACLKFE LMGCEEPKQE
1460 1470 1480 1490 1500
PLLGYDYGYS PCVDNEPPIF QNCPQQPIVV RRDENGGVLP VNFTEPTAVD
1510 1520 1530 1540 1550
NSGSIARLEI KPQNFRTPSY IFKDTVVKYV AFDYDGNVAI CEINITVPDV
1560 1570 1580 1590 1600
TPPLLQCPQS YVIELVDRQD SYTVNFNDTR KRIKTSDDTG DVRLQFSPES
1610 1620 1630 1640 1650
ANIKIGNFEN VTVTATDKYN NRAACHFQVS VKASPCVDWE LQPPANGAIN
1660 1670 1680 1690 1700
CLPGDRGIEC IATCKPGFRF TDGEPLKTFS CETSRLWRPT SVVPDCVSEN
1710 1720 1730 1740 1750
TEQAAYHVTA SITYRANGAV AQSCLGQYQE VLAQHYGGLN QLLSQRCSAV
1760 1770 1780 1790 1800
NVNMNVTFVK SVPMLLEENV VKMDFILSIL PAVRQPQLYD LCGSTLNLIF
1810 1820 1830 1840 1850
DLSVPYASAV IDDLLNIANI GNQCPPLRAL KSQISRGFNC NVGEVLNMDT
1860 1870 1880 1890 1900
SDVPRCLHCP AGTYVSEGQN SCTYCPRGYY QNRDRQGTCL RCPAGTYTKE
1910 1920 1930 1940 1950
EGTKSQADCI PVCGYGTYSP TGLVPCLECP RNSFTAEPPT GGFKDCQACP
1960 1970 1980 1990 2000
AQSFTYQPAA SNKDLCRAKC APGTYSATGL APCSPCPLHH YQGAAGAQSC
2010 2020 2030 2040 2050
NECPSNMRTD SPASKGREQC KPVVCGEGAC QHGGLCVPMG HDIQCFCPAG
2060 2070 2080 2090 2100
FSGRRCEQDI DECASQPCYN GGQCKDLPQG YRCECPAGYS GINCQEEASD
2110 2120 2130 2140 2150
CGNDTCPARA MCKNEPGYKN VTCLCRSGYT GDQCDVTIDP CTANGNPCGN
2160 2170 2180 2190 2200
GASCQALEQG RYKCECVPGW EGIHCEQNIN DCSENPCLLG ANCTDLVNDF
2210 2220 2230 2240 2250
QCACPPGFTG KRCEQKIDLC LSEPCKHGTC VDRLFDHECV CHPGWTGSAC
2260 2270 2280 2290 2300
DINIDDCENR PCANEGTCVD LVDGYSCNCE PGYTGKNCQH TIDDCASNPC
2310 2320 2330 2340 2350
QHGATCVDQL DGFSCKCRPG YVGLSCEAEI DECLSDPCNP VGTERCLDLD
2360 2370 2380 2390 2400
NKFECVCRDG FKGPLCATDI DDCEAQPCLN NGICRDRVGG FECGCEPGWS
2410 2420 2430 2440 2450
GMRCEQQVTT CGAQAPCQND ASCIDLFQDY FCVCPSGTDG KNCETAPERC
2460 2470 2480 2490 2500
IGDPCMHGGK CQDFGSGLNC SCPADYSGIG CQYEYDACEE HVCQNGATCV
2510 2520 2530 2540 2550
DNGAGYSCQC PPGFTGRNCE QDIVDCKDNS CPPGATCVDL TNGFYCQCPF
2560 2570 2580 2590 2600
NMTGDDCRKA IQVDYDLYFS DPSRSTAAQV VPFPTGEANS LTVAMWVQFA
2610 2620 2630 2640 2650
QKDDRGIFFT LYGVQSARMT QQRRMLLQAH SSGVQVSLFE DQPDAFLSFG
2660 2670 2680 2690 2700
EYTSVNDGQW HHVAVVWDGI SGQLQLITEG LIASKMEYGA GGSLPGYLWA
2710 2720 2730 2740 2750
VLGLPQPYGL SNELAYSDSG FQGTITKAQV WARALDITSE IQKQVRDCRS
2760 2770 2780 2790 2800
EPVLYPGLIL NWAGYEVTSG GVERNVPSLC GQRKCPVGYT GANCQQLVVD
2810 2820 2830 2840 2850
KEPPVVEHCP GDLWVIAKNG SAVVSWDEPH FSDNIGVTKI YERNGHRSGT
2860 2870 2880 2890 2900
TLLWGTYDIT YIASDAAGNT ASCSFKVSLL TDFCPALADP VGGSQVCKDW
2910 2920 2930 2940 2950
GAGGQFKVCE IACNAGLRFS EPVPEFYTCG AEGFWRPTRE PSMPLVYPSC
2960 2970 2980 2990 3000
SPSKPAQRVF RIKMLFPSDV LCNKAGQAVL RQKVTNSVNG LNRDWNFCSY
3010 3020 3030 3040 3050
AIEGTRECKD IQIDVKCDHY RGTQNNRVRR QAKDGGVYVM EAELPVVNDD
3060 3070 3080 3090 3100
DDDLTLTGRQ GRQQTGGDTY TLEIAFPAAN DPVVHTSTGE RSTVKQLLEK
3110 3120 3130 3140 3150
LILEDDQFAV QEILPNTVPD PASLELGSEY ACPVGQVVMI PDCVPCAIGT
3160 3170 3180 3190 3200
FYDSANKTCI ACSRGTYQSE AGQLQCSKCP VIAGRPGVTA GPGARSAADC
3210 3220 3230 3240 3250
KERCPAGKYF DAETGLCRSC GHGFYQPNEG SFSCELCGLG QTTRSTEATS
3260 3270 3280 3290 3300
RKECRDECSS GQQLGADGRC EPCPRGTYRL QGVQPSCAAC PLGRTTPKVG
3310 3320 3330 3340 3350
ASSVEECTLP VCSAGTYLNA TQNMCIECRK GYYQSESQQT SCLQCPPNHS
3360 3370 3380 3390 3400
TKITGATSKS ECTNPCEHIA EGKPHCDVNA YCIMVPETSD FKCECKPGFN
3410 3420 3430 3440 3450
GTGMACTDVC DGFCENSGAC VKDLKGTPSC RCVGSFTGPH CAERSEFAYI
3460 3470 3480 3490 3500
AGGIAGAVIF IIIIVLLIWM ICVRSTKRRD PKKMLTPAID QTGSQVNFYY
3510 3520 3530 3540 3550
GAHTPYAESI APSHHSTYAH YYDDEEDGWE MPNFYNETYM KDGLHGGKMS
3560 3570 3580
TLARSNASLY GTKEDLYDRL KRHAYTGKKE KSDSDSEVQ
Length:3,589
Mass (Da):390,572
Last modified:November 30, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1355088FD01A4E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VM55Q9VM55_DROME
Uninflatable, isoform B
uif CT26172, Dmel\CG9138, Poly-EGF, poly-EGF, SP1070
3,557Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: ACZ94190.1
AE014134 Genomic DNA Translation: AFH03596.1
AE014134 Genomic DNA Translation: AFH03597.1
AE014134 Genomic DNA Translation: AFH03598.1

NCBI Reference Sequences

More...
RefSeqi
NP_001162899.1, NM_001169428.3
NP_001245922.1, NM_001258993.2
NP_001245923.1, NM_001258994.2
NP_001245924.1, NM_001258995.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0302162; FBpp0291372; FBgn0031879
FBtr0307072; FBpp0297915; FBgn0031879
FBtr0307073; FBpp0297916; FBgn0031879
FBtr0307074; FBpp0297917; FBgn0031879

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33983

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: ACZ94190.1
AE014134 Genomic DNA Translation: AFH03596.1
AE014134 Genomic DNA Translation: AFH03597.1
AE014134 Genomic DNA Translation: AFH03598.1
RefSeqiNP_001162899.1, NM_001169428.3
NP_001245922.1, NM_001258993.2
NP_001245923.1, NM_001258994.2
NP_001245924.1, NM_001258995.2

3D structure databases

SMRiE1JHA6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0297915

PTM databases

SwissPalmiE1JHA6

Proteomic databases

PRIDEiE1JHA6

Genome annotation databases

EnsemblMetazoaiFBtr0302162; FBpp0291372; FBgn0031879
FBtr0307072; FBpp0297915; FBgn0031879
FBtr0307073; FBpp0297916; FBgn0031879
FBtr0307074; FBpp0297917; FBgn0031879
GeneIDi33983

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33983
FlyBaseiFBgn0031879 uif

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00940000155152
OMAiSQYSGFW
OrthoDBi2171at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
uif fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33983

Gene expression databases

BgeeiFBgn0031879 Expressed in 18 organ(s), highest expression level in embryo
ExpressionAtlasiE1JHA6 differential

Family and domain databases

CDDicd00033 CCP, 3 hits
cd00041 CUB, 3 hits
cd00112 LDLa, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 3 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR003410 HYR_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00431 CUB, 3 hits
PF00008 EGF, 8 hits
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 7 hits
PF00754 F5_F8_type_C, 2 hits
PF12661 hEGF, 3 hits
PF02494 HYR, 3 hits
PF00057 Ldl_recept_a, 1 hit
PF00084 Sushi, 4 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SM00034 CLECT, 1 hit
SM00042 CUB, 3 hits
SM00181 EGF, 21 hits
SM00179 EGF_CA, 15 hits
SM01411 Ephrin_rec_like, 7 hits
SM00231 FA58C, 2 hits
SM00192 LDLa, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 3 hits
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 4 hits
SSF57424 SSF57424, 1 hit
SSF57535 SSF57535, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 3 hits
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 17 hits
PS01187 EGF_CA, 6 hits
PS01285 FA58C_1, 1 hit
PS50022 FA58C_3, 2 hits
PS50825 HYR, 3 hits
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS50923 SUSHI, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1JHA6_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1JHA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again