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Entry version 61 (10 Apr 2019)
Sequence version 4 (10 Apr 2019)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor 17

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-193648 NRAGE signals death through JNK
R-GGA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1C588

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000017326 Expressed in 11 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000027946

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3522 Eukaryota
ENOG410ZJK1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1C588

Database of Orthologous Groups

More...
OrthoDBi
44892at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR039917 ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877 PTHR12877, 1 hit
PTHR12877:SF15 PTHR12877:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1C588-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQPVSSHAG GRGMALAAGQ RDGSRALSCT QCAQQELEEE QPTGCWALHG
60 70 80 90 100
GRRSPALGPS DGLAWGQPQI RARPKLPSGM AKVRADLGSD ALQLVGDRAE
110 120 130 140 150
HRKSLSNPDI ATETLTLLSF LKSDLSELKV KKKGVRIGEA AAYDIPTSNL
160 170 180 190 200
RARGSAQPSG RWAPGERPTL KDLTATLRRA KSFTCSDKSG TRRLFLQSAM
210 220 230 240 250
KQSSSELLLA SASSHDGGRL GDEEGALPVV IQDQYIQEAR QVFEKISRMG
260 270 280 290 300
SQQDYSLVAE QKDSEGVDGA EEVAPMAGMD VALRGQPVST QCLKKVELEE
310 320 330 340 350
DVSCRKSVEE LLGHELSVTD EGIVTEPEPG PTGVALGDLH ETWQLHDNSV
360 370 380 390 400
TANEPPPPPA PAAEDALACK AQAPSDAPNT PSSLRRRRKF PSVGTNGVES
410 420 430 440 450
GTGEGPGEPY RSLSDPMPHR RCPVAEEAKN FSVDSNLLGS LSAKGGIPQP
460 470 480 490 500
SAIALAGHAG SAGSDLSLCS DGLRDYSSLI QTIVSQPGAM DKVIDEKGNG
510 520 530 540 550
KTIKKKSLSD PSRRGELPAG AFEGPGEAIS ELEGSIPPSS SEPILSEQRA
560 570 580 590 600
VPVCPQGVGH GYGFDPKLAE VLSPRGARRS SKKRSGRVSQ QENQVVPTAM
610 620 630 640 650
ARARPATKHV RHTSEPATFV PITVPEPHAG HHAQHPTLEA TRPPVKSFPA
660 670 680 690 700
LQPPSLEDVT KRYMLALNSS DTSPGPGDGS RSSPVTPTAP EPARCPRQPD
710 720 730 740 750
PRSKPQVDMR KHVIMTLLDT EQSYVESLRT LMQGYMKPLK QPENSLLCDP
760 770 780 790 800
SLVDEIFDQI PELLEHHEQF LEQIHDCVQN WHEKQKVGDL LVQSFSKDVL
810 820 830 840 850
VNIYSAYIDN FLNAKDAVRI AKEARPAFMK FLEQSMRENK EKQALSDLMI
860 870 880 890 900
KPVQRIPRYE LLVKDLLKHT PEDHPDHPFL IDAQRNIKQV AERINKGMKS
910 920 930 940 950
AEEVERNARI VQEIESHIEG MEDLQAPLRR FLRQEMVVEV KAVGGKKDRS
960 970 980 990 1000
LFLFTDLLVC TTLKRKSGSL RRSSMSLYTA ASVIDTASKY KLLWKLPLED
1010 1020 1030 1040 1050
VDIIKGASQA TNRESIQKSI CRLDEDLSTL GQVSKLSETL SFPHQSLDDV
1060 1070 1080 1090 1100
IKDLTAAIHR ELAEKQSLSF SMAFPPNKVE LSAAKADGTE SFIFEFPNPD
1110 1120 1130 1140 1150
ARLGFEQALE DAKKKLASSK NCLDPEFLKA IPIMKTRSGM QFSCASPSHS
1160 1170 1180 1190 1200
SPENAHEVWV CNSDGYVGQV CLLSIRKEPI VEACIAVCSA RILCIASVPG
1210 1220 1230 1240 1250
LKRPYRERME PMVSPSSEPA PTQSEDSGPQ QCLHISISGS SLELSEPVDS
1260 1270 1280 1290 1300
AHRELVPFDS DDTDDESSPS PSGTLQSQAS HSTISSSFGN EEIPSCKEAA
1310 1320 1330 1340 1350
AETTSSEEEQ EPGFLPLATA FGQSRRGESP TDGRALRRSS RGSFTRGSLE
1360 1370 1380 1390 1400
DLLSLDPEAY QSSMWLGTED GCIHVYQSSD NIRNRKNSMK MQHAASVMCI
1410 1420 1430
LYLDNQVFVS LANGELIVYQ REPGEAAGWT PKQ
Length:1,433
Mass (Da):155,993
Last modified:April 10, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90DBB52F0D2BD770
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2U6M2A0A3Q2U6M2_CHICK
Rho guanine nucleotide exchange fac...
459Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05001070 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_015136481.1, XM_015280995.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000027999; ENSGALP00000027946; ENSGALG00000017326

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05001070 Genomic DNA No translation available.
RefSeqiXP_015136481.1, XM_015280995.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027946

Proteomic databases

PaxDbiE1C588

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000027999; ENSGALP00000027946; ENSGALG00000017326

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00940000153798
InParanoidiE1C588
OrthoDBi44892at2759

Enzyme and pathway databases

ReactomeiR-GGA-193648 NRAGE signals death through JNK
R-GGA-194840 Rho GTPase cycle

Gene expression databases

BgeeiENSGALG00000017326 Expressed in 11 organ(s), highest expression level in brain

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR039917 ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 1 hit
PTHR12877:SF15 PTHR12877:SF15, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1C588_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1C588
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: April 10, 2019
This is version 61 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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