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Entry version 54 (10 Apr 2019)
Sequence version 4 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

DOCK8

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Z

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1C3X1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000010156 Expressed in 10 organ(s), highest expression level in spleen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000016490

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997 Eukaryota
ENOG410XNVY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155876

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51651 DHR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1C3X1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQLNNLDSE MAHELGDFPE DDLDIVFTPK ECRTLQPSMP EDGVELDSHV
60 70 80 90 100
RDCVQTYIRD WLIVNRKNQG NSDICSLKNK GSRKDFHKHL QKQTFESETS
110 120 130 140 150
DSSDASFQAG PRPVHVLPED TSRTAPASSD FDLRSLQPDP RLENLLRHVS
160 170 180 190 200
AEEFERQNEE ARRTNRHAEL LALYPSVDEE DAVEIRPVPD RPKEHLGNRI
210 220 230 240 250
LVKLQTLKFD IEIEPLFACI ALYDIKERKK ISENFHCDLN PDSLRGFLRS
260 270 280 290 300
HTPSTDLSTQ ARSAVFSVTY PSSDIYLVIK IEKVLQQGEI GDCAEPYMVL
310 320 330 340 350
KENEAGKTKE KIEKLKAQAE CFCQRLGKYR MPFAWIPISL TNFFNVSTLE
360 370 380 390 400
REVSEAEGLN GKGSTSDKRA TLLQARRLSE RSLSTEDSYP VSNFKTVSLT
410 420 430 440 450
HSTFFKQEGD RLSDEDLFKF LADFKRSSSL QRRIKTLPGT LKLEISPAPE
460 470 480 490 500
NLGYCLTPEL LPVKPFPENR SRPHKEILEF PIKEVYVPHT IYRNLLYVYP
510 520 530 540 550
QRLNFANRPA SARNITIKIQ FMCGEDPSCA MPVIFGKSSG PEFVQEMYTA
560 570 580 590 600
ITYHNKSPDF YEEVKIKLPA KLTEKHHLLF TFYHISCQPK QGASVETLIG
610 620 630 640 650
YSWLPILLND RLQTGHYCLP VALDKLPFHY SIHSPEKVPS QTPPIKWVEG
660 670 680 690 700
HKGVFNIEVQ AVSSVHTQDN HLEKFFTLCH SLESQVTFPI RLMDQKITEA
710 720 730 740 750
TLEHELKLSI ICLNSSRLEP LVLFLHLVLD KLFQLAVQPM VIAGQTANFS
760 770 780 790 800
QFAFESVVAI VNSLHNSKYL SKDQHGRNCL LASYVYYVFR LPDPQKEVPK
810 820 830 840 850
LGAGGSAALT ESRYYTFGRT SAVSVGSKLL QSRVISCSNP DITVTQTAAD
860 870 880 890 900
EEVKNIMSSK PADHSSSRMS FYIEGTNDMP GVCTNPRPSS KKHFHEELAL
910 920 930 940 950
QMVVSTGMVR EAVFKYAWFF FELLIKSMAQ YVHSIEKQDN VRRSRFSDRF
960 970 980 990 1000
KDDVTTIVNV VTSEIAALLV KPQKESEQAE KINISLAFFL YDLLSLMDRG
1010 1020 1030 1040 1050
FVFNLIKHYC NQLSNKLNSL STLISMRLEF LRILCSHEHY LNLNLFFMTS
1060 1070 1080 1090 1100
ASTPASPSPS LSSQNSSSCS SFQDQKIAGM FDLSSEYRQQ HFLTGLLFTE
1110 1120 1130 1140 1150
LAAALDADCE GISKVQRKAV SAILSLLSSH DLDPRCSRKE MKIKIAALYL
1160 1170 1180 1190 1200
PLVGIILDSL PQLHDFTISD ARSGKGRTGN PEEEQESAGA ISQNVALAIA
1210 1220 1230 1240 1250
GNQFNLRSSG TSLASLSYRQ SATLGPDTTR NLLICFLWIM KNADQNLIQK
1260 1270 1280 1290 1300
WIADLPSMQL NRILDLLFIC VSCFEYKGKQ SSDKVSNQAL QKSRDVKAKL
1310 1320 1330 1340 1350
EEALLRGEGA RGEMMKRCRI PAGNDRSAGL NENLRWRKEQ TEWRQANERQ
1360 1370 1380 1390 1400
DKTKAELDQE ALISGNLATE ANLIILDMQE NIIQASFAAE CRDNLLGGVL
1410 1420 1430 1440 1450
KVLVNSLGCD QSTTYLTHCF ATLRALIAKF GDFLFEEEVE QCADLCQRVL
1460 1470 1480 1490 1500
HHCSSSIDIT RTQACATLYL LMRYSFSSTS NFARVKMQVT MSLASLVGKS
1510 1520 1530 1540 1550
PEFNEEFLRR SLRTILAYAE EDVDMQATPF PIQVEELLCN LNSILSDTVK
1560 1570 1580 1590 1600
MREFQEDPEM LMDLMYRIAK GYQTSPDLRL TWLQNMAEKH TKRKCYTEAA
1610 1620 1630 1640 1650
MCLVHAAALV AEYLSMLEDR SYLPVGSVSF QNISSNVLEE SAVSDDVLSP
1660 1670 1680 1690 1700
DEDGICSGRY FSESGLVGLL EQAAELFNTG GLYETVNEVY KIVIPILEAH
1710 1720 1730 1740 1750
RDFRKLTLTH SKLQKAFDSI INKGQKRMFG TYFRVGFYGS KFGDLDEQEF
1760 1770 1780 1790 1800
VYKEPAITKL PEISHRLEGF YGQCFGEDNV EVIKDSAPVD KSKLDPNKAY
1810 1820 1830 1840 1850
IQITFVEPYF DEYEMKDRVT YFEKNFNLSR FMYTTPFTMD GRPRGELSEQ
1860 1870 1880 1890 1900
YKRNTILTTM HAFPYIKTRI NIIQKEEFIL TPIEVAIEDM RKKTQELTAA
1910 1920 1930 1940 1950
TNQEPPDAKM LQMVLQGSVG ATVNQGPLEV AQVFLAEIPA DPKLYRHHNK
1960 1970 1980 1990 2000
LRLCFKEFIM RCGEAVNKNK HLITADQREY QQELRKNYGK LKENLRPMIE
2010 2020 2030
RKIPELYKPV VKVNSSRESF RNHSFRKYDA QTSQST
Length:2,036
Mass (Da):231,438
Last modified:April 10, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i586BAECB2A64902C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5P7X8A0A1D5P7X8_CHICK
Uncharacterized protein
DOCK8
1,947Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC188690 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000016509; ENSGALP00000016490; ENSGALG00000010156

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC188690 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016490

Proteomic databases

PaxDbiE1C3X1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016509; ENSGALP00000016490; ENSGALG00000010156

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00940000155876

Enzyme and pathway databases

ReactomeiR-GGA-983231 Factors involved in megakaryocyte development and platelet production

Gene expression databases

BgeeiENSGALG00000010156 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51651 DHR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1C3X1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1C3X1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: April 10, 2019
This is version 54 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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