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Entry version 73 (02 Jun 2021)
Sequence version 4 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

BEST1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi10Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi10Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi293Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi293Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi296Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi296Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi301Calcium 1Combined sources1
Metal bindingi301Calcium 2Combined sources1
Metal bindingi304Calcium 1Combined sources1
Metal bindingi304Calcium 2Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelARBA annotation
Biological processIon transport, Transport
LigandCalciumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-2672351, Stimuli-sensing channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.46.1.6, the anion channel-forming bestrophin (bestrophin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BEST1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 54HelicalSequence analysisAdd BLAST24
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei235 – 257HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi135 ↔ 185Combined sources

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000007217, Expressed in colon and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1C3A0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61344N

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000011669

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1C3A0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni411 – 433DisorderedSequence analysisAdd BLAST23
Regioni564 – 623DisorderedSequence analysisAdd BLAST60
Regioni667 – 734DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi573 – 589Polar residuesSequence analysisAdd BLAST17
Compositional biasi677 – 733Polar residuesSequence analysisAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bestrophin family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3547, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018069_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1C3A0

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIYRMAL

TreeFam database of animal gene trees

More...
TreeFami
TF315803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033041, Best1
IPR000615, Bestrophin
IPR021134, Bestrophin/UPF0187

The PANTHER Classification System

More...
PANTHERi
PTHR10736, PTHR10736, 1 hit
PTHR10736:SF4, PTHR10736:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01062, Bestrophin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1C3A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVTYTNRVA DARLGTFSQL LLQWKGSIYK LLYSEFLIFI SLYFAISLVY
60 70 80 90 100
RLILSESQRL MFEKLALYCN SYAELIPVSF VLGFYVSLVV SRWWAQYESI
110 120 130 140 150
PWPDRIMNLV SCNVDGEDEY GRLLRRTLMR YSNLCSVLIL RSVSTAVYKR
160 170 180 190 200
FPSMEHVVRA GLMTPEEHKK FESLNSPHNK FWIPCVWFSN LAVKARNEGR
210 220 230 240 250
IRDSVLLQGI LNELNTLRSQ CGRLYGYDWI SIPLVYTQVV TVAVYSFFLA
260 270 280 290 300
CLIGRQFLDP EKAYPGHELD LFVPVFTFLQ FFFYAGWLKV AEQLINPFGE
310 320 330 340 350
DDDDFETNWL IDRNLQVSLM AVDEMHQDLP ILEKDLYWNE PDPQPPYTAA
360 370 380 390 400
TAEYKRPSFL GSTFDISMQK EEMEFQPLEQ IKENEEANHS TPLLGHLGRL
410 420 430 440 450
LGVQSPSFSR SSSRMNLLRR RGEPTSPFSH YTYQDMGKSG NISHPRGDTN
460 470 480 490 500
SQEHWDGEDR KLREFDAFIS TPFYERPGFY SAPQTPISSI PMIFPSRRQG
510 520 530 540 550
RKKPPALSSI AACSNSLKDV VNSSPSRMSD TYKSQSSLGS GAKETFIWPT
560 570 580 590 600
ERNKGPDSLV VMVEEEKSNS SSKSREAAIT GSPAALSTAS DSPKFPFLAE
610 620 630 640 650
SPDHEQQGSF KSLKSLKGSH PPWLTLENAA TTTSNCEQSS AFPQPGNIPP
660 670 680 690 700
SSSTSFCFSF TPVASPVLER SPIGNRGPDT HSLSSEDTAS APDQHPSEVS
710 720 730 740 750
RSGRDTASRS SNAPPTRETR RAESPSTNDS GISLAEGDYV GLMEVIMEAS
760
ESVCEEQMDQ CS
Length:762
Mass (Da):85,786
Last modified:April 10, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E21974583C0CF15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2UAP6A0A3Q2UAP6_CHICK
Bestrophin homolog
BEST1
736Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000683 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_421055.2, XM_421055.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000011683; ENSGALP00000011669; ENSGALG00000007217

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
423124

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000683 Genomic DNA No translation available.
RefSeqiXP_421055.2, XM_421055.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RDQX-ray2.85A/B/C/D/E2-405[»]
5T5NX-ray3.10A/B/C/D/E2-405[»]
6N23electron microscopy3.10A/B/C/D/E2-405[»]
6N24electron microscopy3.00A/B/C/D/E2-344[»]
6N25electron microscopy2.70A/B/C/D/E2-344[»]
6N26electron microscopy3.00A/B/C/D/E2-344[»]
6N27electron microscopy3.00A/B/C/D/E2-344[»]
6N28electron microscopy2.90A/B/C/D/E2-344[»]
SMRiE1C3A0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61344N
STRINGi9031.ENSGALP00000011669

Protein family/group databases

TCDBi1.A.46.1.6, the anion channel-forming bestrophin (bestrophin) family

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
E1C3A0, 1 sequenced antibody

Genome annotation databases

EnsembliENSGALT00000011683; ENSGALP00000011669; ENSGALG00000007217
GeneIDi423124

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7439

Phylogenomic databases

eggNOGiKOG3547, Eukaryota
GeneTreeiENSGT00940000158650
HOGENOMiCLU_018069_5_0_1
InParanoidiE1C3A0
OMAiFIYRMAL
TreeFamiTF315803

Enzyme and pathway databases

ReactomeiR-GGA-2672351, Stimuli-sensing channels

Gene expression databases

BgeeiENSGALG00000007217, Expressed in colon and 4 other tissues
ExpressionAtlasiE1C3A0, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033041, Best1
IPR000615, Bestrophin
IPR021134, Bestrophin/UPF0187
PANTHERiPTHR10736, PTHR10736, 1 hit
PTHR10736:SF4, PTHR10736:SF4, 1 hit
PfamiView protein in Pfam
PF01062, Bestrophin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1C3A0_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1C3A0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 73 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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