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Entry version 70 (10 Apr 2019)
Sequence version 3 (30 Nov 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

ARAP3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARAP3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000002562 Expressed in 9 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1C2Q5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000004038

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 70SAMInterPro annotationAdd BLAST65
Domaini442 – 534PHInterPro annotationAdd BLAST93
Domaini550 – 639PHInterPro annotationAdd BLAST90
Domaini636 – 767Arf-GAPInterPro annotationAdd BLAST132
Domaini965 – 1063PHInterPro annotationAdd BLAST99
Domaini1067 – 1248Rho-GAPInterPro annotationAdd BLAST182
Domaini1277 – 1370Ras-associatingInterPro annotationAdd BLAST94
Domaini1383 – 1485PHInterPro annotationAdd BLAST103

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili620 – 640Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158869

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1C2Q5

KEGG Orthology (KO)

More...
KOi
K12490

Database of Orthologous Groups

More...
OrthoDBi
98944at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105769

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04385 RhoGAP_ARAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 5 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 2 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF54236 SSF54236, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1C2Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPCTPDSD IADWLATIHL ERYRDLFKQH GFHLARDVAA LDNKQLQQLG
60 70 80 90 100
ITATGHRKRI LNLAEKTRLL GDPHPRAPQM GEDATKAEPG VAADAFGMQK
110 120 130 140 150
CNAVPRQVML LQKDLDPPLV RPVPKPRTVF YRPKLEQGSA ATPAAHSQDR
160 170 180 190 200
DGTAGAFVVL EGFVPGESST DLESPGATMG TGTSRLGAQE EAQLPAVPDH
210 220 230 240 250
GETQETPEKP CLCVPSVPPR LRHRVPVAEL SAVGATVRPP SVPGVGQGRM
260 270 280 290 300
EMVSNVIYEG FKQPLAPVED SGQEDSPRGQ ALTQDPSPQE LTQLAEKPNR
310 320 330 340 350
ASWPGGGLPP IPQRPASKPE FSEPPISPYS ETTFGNTVPA REQKGTDVPS
360 370 380 390 400
GQSYEAVTEL EQETQRTSSE YSSEGRSEDE ETRTRLIERI VQNDTEGYST
410 420 430 440 450
VDAPRAKGTP FSLPPHLYPD EVLDDLTISP YASYTSLSEP RPAMLSGWLD
460 470 480 490 500
KLSPQGNYVF QRRYVRFDGK NLMYFSSEKE PYPKGVIPLP VIEMVRSTKD
510 520 530 540 550
NKFQVVTSHR IFVFRAENEA QRNEWCSTLQ QKVMDQHLVG TRPRPLNTAH
560 570 580 590 600
CQKSGTLELK GQKSKVFAVL SLPEMWLYKS EQFFKMGIGI CMIEMRGSTI
610 620 630 640 650
REAKNRIFEL ITPSKIFSFV AESEREKREW MEALQEAIAE TLYDYEVAEK
660 670 680 690 700
IWSNKANRYC ADCWAHSPDW ASINLCVVIC KQCAGQHRSL GSNISKVQSL
710 720 730 740 750
KLDTSVWSNE IVQLFIVLGN DRANRFWAAR IPATEVLHPD ASTEQRRDFI
760 770 780 790 800
SRKYRDGRYR LPHPHYASHE DVLQALCTAV AGPSLLKTIL QFFSAAEAGL
810 820 830 840 850
AADPTAPDIT PVAEPWWDLE SKRNHAGVPG PEGVYNEITQ PVAHSGYLHR
860 870 880 890 900
SMAHPRLPGA KKSRDDFQRV WCSLERALLI FETEKCTEPL SHIQSGDLLS
910 920 930 940 950
LGVSRAQPIS SPGPTERFHF ILELFLTGEK VQQLGADSAD TLQAWASAIG
960 970 980 990 1000
KWFTPVSCHC LLGYEFQRVG QLRYKCMLNP ERWQRAFFIL QKAHLFICPA
1010 1020 1030 1040 1050
EEDGAEDSIN LRRLQELSLV PPAEMPEKKE MLVLVEMGRT FYLQGLSRAD
1060 1070 1080 1090 1100
TAAWYADIQA SAGGRGNALR DQQLSRGDIP IIVDSCIAFI TQYGLRHEGI
1110 1120 1130 1140 1150
YRKNGAKSRI KVLMEEFRRD ARNVKLRISD NFIEDVTDVL KRFFRELEDP
1160 1170 1180 1190 1200
VFTLELHPQW KEAAAISSKP QRLERYKELI HRLPRLNRKT LAALIGHLYR
1210 1220 1230 1240 1250
VQKCADLNQM STKNLSLLFA PSLFQTDGKG EHEVKVMEDL IDNYVTIFNI
1260 1270 1280 1290 1300
DEDQVSQMDL ENSLITTWKD TQLSQAGDLI IEVYLEQKLP DCCVTLKVSP
1310 1320 1330 1340 1350
TMTAEELTNQ VLEMRNVAAS LDIWLTFEVL ENGELERPLH PKEKVLEQAL
1360 1370 1380 1390 1400
QWCKLPEPSA AYLLVRKVPI GEGSCLFTGA KRESPKCGLL KCREEPPKLL
1410 1420 1430 1440 1450
GNKFHERYFV IRDRQLLLLK EKRSAKPERE WPLDVAKVYM GIRKKLKPPA
1460 1470 1480 1490 1500
PWGFTLSMDK QQLYLVCTGQ AELWDWITSI LKAQHDDQRP VIMRRRSSSD
1510 1520 1530 1540 1550
LAKQKFGTMP LVPLHGDSTD ATMLSANQTL RRLHTRRTLS MFFPMKVHQD
1560 1570 1580 1590 1600
SLEEQQEKEV DTEPVYEEVG NFPELATLEL QRGLLADPSP VPTMDRSQKP
1610 1620 1630 1640 1650
SSSPEQPPAP VLRSSLPPSP AQRLPAPSVT KAVSLERGLN LECDKAPSCG
1660 1670 1680 1690 1700
LRATLTASLE RNLEPPTVLA RDQEQTAVLG HSSSPETSIS TKKRSAQPSS
1710 1720 1730
PISDKLIQEL SSIILKKSDG QTQGTGTGTG SGQPVT
Length:1,736
Mass (Da):194,499
Last modified:November 30, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2648C3FB5DAC5AFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PEH9A0A1D5PEH9_CHICK
Uncharacterized protein
ARAP3
1,723Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000072 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_015149114.1, XM_015293628.1
XP_015149115.1, XM_015293629.1
XP_015149116.1, XM_015293630.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.13136

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000004047; ENSGALP00000004038; ENSGALG00000002562

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
416196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:416196

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000072 Genomic DNA No translation available.
RefSeqiXP_015149114.1, XM_015293628.1
XP_015149115.1, XM_015293629.1
XP_015149116.1, XM_015293630.1
UniGeneiGga.13136

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004038

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000004047; ENSGALP00000004038; ENSGALG00000002562
GeneIDi416196
KEGGigga:416196

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64411

Phylogenomic databases

GeneTreeiENSGT00940000158869
InParanoidiE1C2Q5
KOiK12490
OrthoDBi98944at2759
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-GGA-194840 Rho GTPase cycle

Gene expression databases

BgeeiENSGALG00000002562 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiE1C2Q5 baseline and differential

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 5 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 2 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF54236 SSF54236, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1C2Q5_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1C2Q5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 30, 2016
Last modified: April 10, 2019
This is version 70 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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