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Entry version 81 (05 Jun 2019)
Sequence version 2 (30 Nov 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

BCR

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationSAAS annotation, Guanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCRImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1C0M5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000006695 Expressed in 11 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000010805

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini578 – 771DHInterPro annotationAdd BLAST194
Domaini788 – 946PHInterPro annotationAdd BLAST159
Domaini950 – 1082C2InterPro annotationAdd BLAST133
Domaini1134 – 1328Rho-GAPInterPro annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 206DisorderedSequence analysisAdd BLAST130
Regioni284 – 309DisorderedSequence analysisAdd BLAST26
Regioni362 – 517DisorderedSequence analysisAdd BLAST156
Regioni533 – 571DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili28 – 48Sequence analysisAdd BLAST21
Coiled coili864 – 884Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi98 – 123PolyampholyteSequence analysisAdd BLAST26
Compositional biasi140 – 182PolyampholyteSequence analysisAdd BLAST43
Compositional biasi284 – 306PolarSequence analysisAdd BLAST23
Compositional biasi400 – 471PolarSequence analysisAdd BLAST72
Compositional biasi540 – 566PolarSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4269 Eukaryota
ENOG410XPGZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153491

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1C0M5

Database of Orthologous Groups

More...
OrthoDBi
762492at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E1C0M5

TreeFam database of animal gene trees

More...
TreeFami
TF105082

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
4.10.280.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037769 Abr/Bcr
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23182 PTHR23182, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF00168 C2, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
SSF69036 SSF69036, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1C0M5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDPVGFVEA WKAQFADSEP PKMELKSVGD IEQELEMCKA SIRRLEMEVN
60 70 80 90 100
KERFRMIYLQ TLLAKEKKSY DRQRWGFKRA SQLPEGGADQ QIQDLPHHQS
110 120 130 140 150
ADQDEHEKSK SQHGEEKFKP RIPSLRKLST QSDGSDLSPL DSPHHGEGEQ
160 170 180 190 200
DRCKYYGEEK LKRVVEDTES RCDTDGSPSK HRSSSTRRLV GSAEKEGLFE
210 220 230 240 250
PISKDRGNST SVAALRSNFE RIKKGNSHHS GDNKDVVEKP FYVNMEYHHE
260 270 280 290 300
KGLVKVNDKD VSDKISSLGS QAMQMERKKS LHSLPSNMVP SFNEFQRPTY
310 320 330 340 350
RGRSSESSFG YDGEYEDAEL NPRFLKDNLI NANGSNRSPW QPMDFQPYQS
360 370 380 390 400
IYVGGMMGET EGKGPILRNQ GTTDQEKHLT WPRRSYSPRS FEDIGGGYTP
410 420 430 440 450
DCSSNENLTS SEEDFSSGQS SHVSPSPTTY RMYRDKSRSP SQNSQQSFDS
460 470 480 490 500
SSPPTPQSQK RHRQQQVIVS EATIVGVRKT GQIWPSDGDL PSGRCHQDSL
510 520 530 540 550
FHGDADASFS GTPPSYAYDA DRAEEQRRHH DMMPYIDDSP SSSPHLSSKS
560 570 580 590 600
RGSRDTLSSG SLESTKSSEP DLEKGLEMRK WVLSGILASE ETYLSHLEAL
610 620 630 640 650
LLPMKPLKAA ATTSQPVLTS QQIETIFFKV PELYEIHKEF YDGLFPRVQQ
660 670 680 690 700
WSHQQRVGDL FQKLASQLGV YRAFVDNYEV AMETAEKCCQ ANAQFAEISE
710 720 730 740 750
NLKARSTKES KDQTTKNSLE TLLYKPVDRV TRSTLVLHDL LKHTPVSHPD
760 770 780 790 800
HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE
810 820 830 840 850
GARKLRHVFL FTDLFLCAKL KKQIGGKSQQ YDCKWYIPLT DLSFQMVDES
860 870 880 890 900
EAVPNIPLVP DEELDAMKIK ISQIKNDIQR EKRANKGSKV IERLKKKLSE
910 920 930 940 950
QESLLLLMSP NMAFRVHNRN GKSYTFLISS DYERAEWREN IREQQKKCFK
960 970 980 990 1000
SFSLTSVELQ MLTNSCVKLQ TVHNIPLTIN KEDDESPGLY GFLNVIVHSA
1010 1020 1030 1040 1050
TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTTEPNWNE EFEIELEGSQ
1060 1070 1080 1090 1100
TLRILCYEKC YNKMKLTKED GESTDRIMGK GQIQLDPQTL QDKDWQRTVI
1110 1120 1130 1140 1150
SMNGVEVKLS VKFTSREFSL KRMPSRKQTG VFGVKIAIVT KRERSKVPYI
1160 1170 1180 1190 1200
VRQCVEEIER RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD
1210 1220 1230 1240 1250
VNAIAGTLKL YFRELPEPLF TDELYPNFAE GIALSDPVAK ESCMLNLLLS
1260 1270 1280 1290 1300
LPEPNLVTFL FLLDHLKRVA ERESINKMSL HNLATVFGPT LLRPSEKDSK
1310 1320 1330 1340 1350
IPANPTQPIT MTDSWSLEVM SQVQVLLYFL QLETIPTPDS KRQSILFSTE

V
Length:1,351
Mass (Da):153,869
Last modified:November 30, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDED85E48CDE74A6D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000505 Genomic DNA No translation available.
AC157663 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_415244.3, XM_415244.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000010819; ENSGALP00000010805; ENSGALG00000006695

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
416952

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000505 Genomic DNA No translation available.
AC157663 Genomic DNA No translation available.
RefSeqiXP_415244.3, XM_415244.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010805

Proteomic databases

PaxDbiE1C0M5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000010819; ENSGALP00000010805; ENSGALG00000006695
GeneIDi416952

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
613

Phylogenomic databases

eggNOGiKOG4269 Eukaryota
ENOG410XPGZ LUCA
GeneTreeiENSGT00940000153491
InParanoidiE1C0M5
OrthoDBi762492at2759
PhylomeDBiE1C0M5
TreeFamiTF105082

Enzyme and pathway databases

ReactomeiR-GGA-194840 Rho GTPase cycle

Gene expression databases

BgeeiENSGALG00000006695 Expressed in 11 organ(s), highest expression level in brain

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
4.10.280.30, 1 hit
InterProiView protein in InterPro
IPR037769 Abr/Bcr
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PANTHERiPTHR23182 PTHR23182, 1 hit
PfamiView protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF00168 C2, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
SSF69036 SSF69036, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1C0M5_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1C0M5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 30, 2016
Last modified: June 5, 2019
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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